CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2125
Family Name Amine oxidase [flavin-containing] A and Amine oxidase [flavin-containing] B Inhibitor Trans-2-(4-chlorophenyl)-2-fluorocyclopropanamine Family
No. of Seeds 6 No. of Other Members 24
Family Centroid CFAMM00260583 Functional Category Investigative Drug
Superfamily Amine oxidase [flavin-containing] A and Amine oxidase [flavin-containing] B Inhibitor Trans-2-(4-chlorophenyl)-2-fluorocyclopropanamine Superfamily
Class Class 1946

Cousin Family NamesSeedsMembers
Alpha-1B adrenergic receptor ligand phenethylamine derivative ... 12 283
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Sibu... 7 127
Noradrenergic re-uptake Inhibitor Phentermine Family 2 11
Glutamate receptor AMPA subtype and Noradrenaline uptake Ligan... 9 17
Dopamine reuptake and Noradrenergic re-uptake Inhibitor Dov 21... 16 89
5-hydroxytryptamine receptor 2C Ligand Lorcaserin Family 8 38
Gamma-aminobutyric acid B receptor Ligand Phaclofen Family 1 3
Beta-secretase 1 Inhibitor 4-(4-fluorobenzyl)piperidine Family 2 4
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 3 7
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 6 7
Dipeptidyl peptidase 4 Inhibitor C-(2'-chloro-biphenyl-2-yl)-m... 2 5
Amine oxidase [flavin-containing] A Inhibitor Trans-(+/-)-2-fl... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 5 6
Sodium-dependent dopamine transporter inhibitor [3-(4-chloroph... 1 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 4
Sodium-dependent dopamine transporter and Sodium-dependent nor... 3 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 4
Kinesin-like protein KIF11 inhibitor 4-(4-chlorophenyl)-4,4-di... 1 2
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 2


External ID

Functional Category

Molecule Name

CFAMM00260592 CHEMBL451232 Bioactive [(1S,2S)-2-(2-chloro-4-fluorophenyl)cyclopropyl]methanamine;hydrochloride
CFAMM00260588 CHEMBL493128 Bioactive [(1S,2S)-2-(3-chlorophenyl)cyclopropyl]methanamine;hydrochloride
CFAMM00260577 DNC006918 Investigative Drug (+/-)-6-(2-chlorophenyl)cyclohex-3-enamine
CFAMM00260583 DNC009547 Investigative Drug trans-2-(4-chlorophenyl)-2-fluorocyclopropanamine
CFAMM00260567 DNC009551 Investigative Drug cis-2-(4-chlorophenyl)-2-fluorocyclopropanamine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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