CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID214
Family Name Arachidonate 5-lipoxygenase Inhibitor Caffeic Acid Family
No. of Seeds 3 No. of Other Members 32
Family Centroid CFAMM00184469 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Epidermal growth factor receptor and Arachidonate 5-lipoxygenase Binder Superfamily
Class Class 1471

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand catecholamine Dopamine family 9 170
Dopamine receptor ligand L-Tyrosine derivative Levodopa Family 4 59
Alpha adrenergic receptor ligand L-Tyrosine derivative Methyld... 2 3
Fatty-acid amide hydrolase 1 Inhibitor Propofol Family 5 428
Prostaglandin G/H synthase 1 Inhibitor Salicyclic Acid Family 3 39
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Oestrogen receptor ligand Dienestrol Family 35 440
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
taste receptor Ligand Cynarin Family 6 124
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Muscarinic acetylcholine receptor M1 Ligand GSK1034702 Family 7 148
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Translocator protein Inhibitor Dextofisopam Family 3 250
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Oxi4503 family 4 27
Glucose-6-phosphate translocase Inhibitor Kodaistatin A Family 1 0
Macrophage migration inhibitory factor and Prothrombin Inhibit... 2 49
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Arachidonate 15-lipoxygenase Inhibitor Isoscopoletin Family 5 98
Platelet-activating factor receptor Ligand L-652731 Family 5 116
Tyrosine-protein kinase Lck Inhibitor 2-(3,4,5-trihydroxy-benz... 2 6
Epidermal growth factor receptor Ligand AG-538 Family 5 11
Epidermal growth factor receptor Ligand 2-cyano-3-(3,4-dihydro... 1 0
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 5 13
4-aminobutyrate aminotransferase, mitochondrial and Succinate-... 4 22
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
Tubulin beta chain Inhibitor Combretastatin Family 3 5
L-selectin and P-selectin Inhibitor 2,3,4-trihydroxybenzoic Ac... 2 10
Arachidonate 15-lipoxygenase and Arachidonate 5-lipoxygenase I... 3 18
Neutrophil elastase Inhibitor Bornyl (3,4,5-trihydroxy)-cinnam... 1 0
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Protein kinase C alpha type Inhibitor Acetoside Family 5 39
Squalene monooxygenase Inhibitor Octyl_gallate Family 5 5
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 6-meth... 2 36
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-54162 Family 1 3
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor P-coum... 1 1
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Androgen receptor Ligand Palodesangren E Family 12 43
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Amine oxidase [flavin-containing] B Inhibitor Methyl Piperate ... 1 19
DNA polymerase Inhibitor 3alpha-o-trans-p-coumaroyl-7-labden-1... 1 13
Aromatase inhibitor (3R,4R)-4-benzyl-3-[(3-hydroxyphenyl)methy... 1 10
Heat shock protein HSP 90-alpha inhibitor Catalposide family 5 22
Glycogen phosphorylase, muscle form and Glycogen phosphorylase... 1 2
G2/mitotic-specific cyclin-B1 and Cyclin-dependent kinase 1 in... 2 8
Integrase inhibitor AC1O6FK1 family 1 0
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor propan... 3 5
DNA polymerase beta and Thioredoxin glutathione reductase inhi... 1 0
Glutamate carboxypeptidase 2 inhibitor 2-[(3-hydroxyphenyl)met... 1 0
Eukaryotic elongation factor 2 kinase and Proto-oncogene tyros... 1 1
Phenols and Derivatives Metabolite 3,4-Dihydroxyphenylglycol O... 1 1
[(E)-3-carboxy-2-(5-methyl-2-oxidophenyl)prop-2-enyl]-(2-pheny... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00184469 DNC000378 Investigative Drug Caffeic acid
CFAMM00184470 DNC000379 Investigative Drug Caffeic acid phenethyl ester

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27515 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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