CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2144
Family Name Histone deacetylase 1 Inhibitor N-hydroxy-5-(pyridin-3-yl)thiophene-2-carboxamide Family
No. of Seeds 9 No. of Other Members 46
Family Centroid CFAMM00260918 Functional Category Investigative Drug
Superfamily Histone deacetylase 1 Inhibitor N-hydroxy-5-(pyridin-3-yl)thiophene-2-carboxamide Superfamily
Class Class 2366

Cousin Family NamesSeedsMembers
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Cytochrome P450 3A4 Inhibitor 3-(3-methylthiophen-2-yl)pyridin... 5 27
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(2... 2 20
Cysteine protease and Cruzipain inhibitor N-[(E,3S)-1-(benzene... 1 1
Deoxycytidine kinase inhibitor N-[(1S,3S)-3-(4-amino-5-fluoro-... 2 5
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-[4... 4 0
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family 2 6
Sonic hedgehog protein inhibitor 3-chloro-N-[4-(methylamino)cy... 2 3
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1231206 ... 6 7
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor lig... 2 8
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-073U... 3 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 13
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QJ7P family 2 0
Neuromedin-K receptor ligand 3-methylsulfinyl-N-[(1S)-1-phenyl... 3 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 4 11
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 1 2
Glycogen synthase kinase-3 beta inhibitor 7-(6-chloropyridin-2... 2 3
Neuronal acetylcholine receptor subunit alpha-7 ligand AGN-PC-... 7 1
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 16
Coagulation factor X inhibitor AGN-PC-030DHH family 1 0
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 8 4
Cyclin-dependent kinase 8 and Cyclin-dependent kinase 5 inhibi... 1 6
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 2 0
Histone deacetylase 1 inhibitor 5-[1-[2-(3,5-difluoroanilino)-... 2 2
Histone deacetylase 1 inhibitor N-hydroxy-5-[1-[2-[(1-methylin... 4 1
Histone deacetylase 1 inhibitor 5-[5-[[(2-chlorophenyl)methyla... 4 1
NAD-dependent protein deacetylase sirtuin-2 and NAD-dependent ... 8 12
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 4 4
Metabotropic glutamate receptor 1 ligand SureCN8238697 family 2 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 4 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3-fluo... 6 4
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(benzen... 4 4
Intercellular adhesion molecule 1 and E-selectin inhibitor Sur... 1 0
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Gamma-aminobutyric acid receptor subunit alpha-2 and Gamma-ami... 6 4
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 6-(b... 1 0
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor AGN-PC... 2 2
Vasopressin V2 receptor and Vasopressin V1a receptor ligand N-... 1 1
Metabotropic glutamate receptor 5 ligand 2-(2-pyridin-3-ylethy... 1 2
Intercellular adhesion molecule 1 and E-selectin inhibitor Sur... 1 2
Arachidonate 5-lipoxygenase inhibitor AGN-PC-073JGI family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00260940 CHEMBL217097 Bioactive 5-[5-[2-(benzylamino)ethyl]pyridin-2-yl]-N-hydroxythiophene-2-carboxamide
CFAMM00260955 CHEMBL441699 Bioactive N-hydroxy-5-[5-[[2-(2-methylphenyl)ethylamino]methyl]pyridin-2-yl]thiophene-2-carboxamide
CFAMM00260937 CHEMBL216300 Bioactive 5-[5-[[2-(4-fluorophenyl)ethylamino]methyl]pyridin-2-yl]-N-hydroxythiophene-2-carboxamide
CFAMM00260897 CHEMBL2431916 Bioactive AGN-PC-0C7PWC
CFAMM00260917 CHEMBL436964 Bioactive N-hydroxy-5-[5-[[2-(3-methylphenyl)ethylamino]methyl]pyridin-2-yl]thiophene-2-carboxamide
CFAMM00260931 CHEMBL218392 Bioactive N-hydroxy-5-[5-[[(4-phenylphenyl)methylamino]methyl]pyridin-2-yl]thiophene-2-carboxamide
CFAMM00260920 DNC006968 Investigative Drug N-hydroxy-5-(pyridin-4-yl)thiophene-2-carboxamide
CFAMM00260919 DNC006966 Investigative Drug N-hydroxy-5-(pyridin-2-yl)thiophene-2-carboxamide
CFAMM00260918 DNC006967 Investigative Drug N-hydroxy-5-(pyridin-3-yl)thiophene-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27043 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543