CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2146
Family Name Integrin alpha-2 and Integrin beta-3 Inhibitor 3-(3-(carbamoyl)benzamido)propanoic Acid Family
No. of Seeds 7 No. of Other Members 13
Family Centroid CFAMM00260992 Functional Category Investigative Drug with Natural Product
Superfamily Integrin beta-3 and Integrin alpha-2 Binder Superfamily
Class Class 252

Cousin Family NamesSeedsMembers
5-alpha reductase inhibitor azasteroid derivative Dutasteride ... 36 124
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Retinoic acid receptor alpha Ligand Tamibarotene Family 5 95
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Motilin receptor Ligand GSK962040 Family 30 457
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
K-604 family 4 71
Pan-DAC Inhibitor AR-42 Family 21 153
Amonafide family 3 35
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Urokinase-type plasminogen activator Inhibitor 6-(n-phenylcarb... 2 11
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Integrin beta-3 Inhibitor L-709780 Family 9 10
Integrin beta-3 Inhibitor L-767679 Family 3 6
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Integrin beta-3 Inhibitor L-750034 Family 7 38
Integrin beta-3 Inhibitor SB-208651 Family 9 28
Integrin beta-3 Inhibitor Lotrafiban Family 5 1
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Aurora kinase B Inhibitor Hesperadin Family 1 1
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Telomerase reverse transcriptase Inhibitor 2,7-bis[2-(piperidi... 6 8
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Acetylcholinesterase inhibitor AGN-PC-07ZFTY family 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEDE family 7 17
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZFJZ family 1 3
Caspase-1 inhibitor CHEMBL114791 family 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor 2-[7-[[4-(N'-... 7 15
Cathepsin K and Cathepsin B inhibitor AGN-PC-01Z23J family 2 0
C-C chemokine receptor type 3 ligand 4-[(3-acetylphenyl)carbam... 3 4
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 6 6
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7345980... 4 6
C-C chemokine receptor type 3 ligand SureCN6703027 family 2 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 5
Acetylcholinesterase inhibitor CHEMBL1651130 family 2 3
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 10 0
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 6 5
Prelamin-A/C inhibitor CHEMBL1547148 family 1 8
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 5 2
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 8 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 1
Stromelysin-1 inhibitor 6-(4'-FLUORO-BIPHENYL-4-YL)-4-(3-METHY... 3 0
Free fatty acid receptor 1 ligand AGN-PC-03ZC6J family 2 14
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 8 1
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 3 5
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
C-C chemokine receptor type 3 and Sodium-dependent serotonin t... 12 2
Delta-type opioid receptor and Potassium voltage-gated channel... 3 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
C-C chemokine receptor type 3 ligand 1-(3-acetylphenyl)-3-[3-[... 9 1
P2X purinoceptor 7 inhibitor 2-[3-fluoro-4-(trifluoromethyl)ph... 3 0
Prostaglandin E synthase inhibitor 4-chloro-2-[[1,3-dioxo-2-(1... 1 0
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
Integrin beta-3 and Integrin alpha-IIb inhibitor AGN-PC-074AY6... 1 0
Atrial natriuretic peptide receptor 1 and Atrial natriuretic p... 3 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-2-(benze... 2 2
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 4 0
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN6949669... 12 3
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-2-(2-eth... 1 0
Vascular endothelial growth factor receptor 2 ligand isoindoli... 1 0
Glucagon receptor and Gastric inhibitory polypeptide receptor ... 1 6
Coagulation factor X and Tissue factor inhibitor AGN-PC-02WN8Y... 7 22
Glucagon receptor and Gastric inhibitory polypeptide receptor ... 3 1
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
Vascular endothelial growth factor receptor 2 ligand SureCN578... 1 2
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
Integrin beta-3 and Integrin alpha-IIb inhibitor AGN-PC-009EMK... 2 1
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-[2-(1-hydroxy-3... 3 0
Glucagon receptor and Adenylate cyclase type 1 ligand AGN-PC-0... 1 0
Glucose-dependent insulinotropic receptor ligand AGN-PC-04UO8L... 2 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[[1... 2 5
Protein farnesyltransferase subunit beta and Protein farnesylt... 2 4
Serine/threonine-protein kinase Chk1 inhibitor 6-oxo-9-(2-oxo-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00260987 CHEMBL1836351 Bioactive 3-[3-oxo-5-(1,2,3,4-tetrahydroisoquinoline-7-carbonylamino)-1H-isoindol-2-yl]butanoic acid;hydrochloride
CFAMM00260984 CHEMBL1836347 Bioactive 3-[3-oxo-5-(1,2,3,4-tetrahydroisoquinoline-7-carbonylamino)-1H-isoindol-2-yl]propanoic acid;hydrochloride
CFAMM00260983 CHEMBL1836345 Bioactive 3-[3-oxo-5-[(4-piperidin-4-ylbenzoyl)amino]-1H-isoindol-2-yl]propanoic acid;2,2,2-trifluoroacetic acid
CFAMM00260982 CHEMBL218200 Bioactive 3-[[3-nitro-5-(1,2,3,4-tetrahydroisoquinolin-7-ylcarbamoyl)benzoyl]amino]-3-phenylpropanoic acid
CFAMM00260994 DNC006971 Investigative Drug 3-(3-(carbamoyl)benzamido)-3-phenylpropanoic acid
CFAMM00260993 DNC006970 Investigative Drug 3-(3-(benzamido)-5-nitrobenzamido)propanoic acid
CFAMM00260992 DNC006972 Investigative Drug 3-(3-(carbamoyl)benzamido)propanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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