CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2147
Family Name Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-370 Family
No. of Seeds 37 No. of Other Members 1
Family Centroid CFAMM00261011 Functional Category Investigative Drug
Superfamily Pixantrone Superfamily
Class Class 1284

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Prothrombin Inhibitor Ximelegatran Family 8 157
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Histidine decarboxylase Inhibitor Bf-derm1 Family 12 95
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Growth hormone receptor Ligand EP-51216 Family 34 390
Interleukin-1 beta and Interleukin-6 Inhibitor Ibudilast Family 2 11
D(1B) dopamine receptor Ligand LE-300 Family 65 452
D(3) dopamine receptor Ligand SB-277011 Family 13 178
D(4) dopamine receptor Ligand SPI-376 Family 7 84
Substance-P receptor Ligand TAK-637 Family 18 63
Setipiprant family 5 118
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Pixantrone family 2 3
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
NF-kappa-B and Protein kinase C zeta type Inhibitor Go6976 Family 9 71
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-chlorophenyl)-5-... 2 8
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 4
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 1 and G2/mitotic-specific cyclin-B1 In... 2 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 5
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Fatty acid-binding protein, adipocyte and Fatty acid-binding p... 3 11
Cannabinoid receptor 2 Ligand JWH-204 Family 6 10
Cannabinoid receptor 2 Ligand JWH-249 Family 7 13
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Kinesin-like protein KIF11 Inhibitor 9h-carbazole-2-carbaldehy... 1 3
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Metabotropic glutamate receptor 5 Ligand 1-(3-(2-methylquinoli... 2 12
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Metabotropic glutamate receptor 1 Ligand (e)-4,4-dimethyl-1-qu... 2 2
Aldose reductase Inhibitor 3-(3-benzoyl-1h-pyrrol-1-yl)propano... 3 7
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Tubulin beta chain Inhibitor 2-m-tolyl-1h-[1,8]naphthyridin-4-... 5 2
Histone deacetylase Inhibitor ST-5732 Family 8 6
Platelet-activating factor receptor ligand A-85783 family 13 62
Substance-K receptor ligand 1-N,2-N-bis[2-(1H-indol-3-yl)ethyl... 1 0
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... 2 4
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 3 1
Vasopressin V2 receptor and Vasopressin V1a receptor ligand [2... 2 5
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 4
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 13
Progesterone receptor and Androgen receptor ligand AGN-PC-04V9... 2 2
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Disintegrin and metalloproteinase domain-containing protein 17... 2 11
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
Serine/threonine-protein kinase pim-3 and Serine/threonine-pro... 4 6
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Renin inhibitor [(2S,4S,5S,7R)-4-amino-8-(butylamino)-5-hydrox... 3 1
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 1
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Mitogen-activated protein kinase 1 and Nonstructural protein 1... 1 33
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
Serine/threonine-protein kinase D3 and Protein kinase C delta ... 3 0
Metabotropic glutamate receptor 1 ligand [11C]JNJ-16567083 family 9 2
Metabotropic glutamate receptor 1 ligand GTPL6334 family 6 4
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Translocator protein inhibitor AGN-PC-08WI0V family 1 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 0
Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
ALK tyrosine kinase receptor and Insulin receptor ligand 9-eth... 9 8
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SVV family 2 12
Hepatocyte growth factor receptor ligand 9-[[3-methoxypropyl(m... 17 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 1 0
Glycogen synthase kinase-3 beta inhibitor 3-(2-bromoacetyl)-4-... 1 0
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL186461 family 2 4
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 12
Cytochrome P450 2D6 and Cytochrome P450 2C19 inhibitor Demethy... 1 4
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... 5 5
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 2 0
Melanin-concentrating hormone receptor 1 ligand N-[(3S)-1-[[(3... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 6
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand N-(oxan-... 2 0
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Fatty-acid amide hydrolase 1 inhibitor 1-[3-[4-(6-phenylhexyl)... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... 3 2
Prostaglandin D2 receptor 2 ligand 2-[3-[(E)-2-cyano-3-(N-meth... 9 9
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 1 3
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Platelet-activating factor receptor ligand N,N-diethyl-3-[(4R)... 11 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 1
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand (7S)-... 2 19
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 1 0
72 kDa type IV collagenase and Interstitial collagenase inhibi... 1 1
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 0
Cytochrome P450 2C9 inhibitor AGN-PC-04XDND family 1 3
Translocator protein inhibitor N,N-dibutyl-2-(7-chloro-2-pheny... 3 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Mitogen-activated protein kinase 14 inhibitor SureCN14185127 f... 2 0
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-014VFP fa... 1 7
Metabotropic glutamate receptor 1 ligand AGN-PC-07CPMZ family 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 1 0
Cannabinoid receptor 1 ligand [6-bromo-2-methyl-1-(2-morpholin... 3 0
Heat shock protein HSP 90-alpha inhibitor CHEMBL1760611 family 19 25
Amine oxidase [flavin-containing] A inhibitor CHEMBL1917530 fa... 1 0
Methionine aminopeptidase 1 inhibitor ethyl 4-[4-(2-pyridin-2-... 2 3
Steroid hormone receptor ERR1 ligand methyl 3-[4-(2-aminobenzo... 4 2
Histone deacetylase 6 and Histone deacetylase 8 inhibitor N-hy... 1 0
Metabotropic glutamate receptor 5 ligand 3-methyl-1-[2-[3-(tri... 3 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Insulin receptor ligand 2,5-dihydroxy-3-(1H-indol-3-yl)-6-phen... 1 0
Prostaglandin E synthase inhibitor 3-(4-dodecanoyl-1,5-dimethy... 2 0
Arachidonate 5-lipoxygenase inhibitor 1-[1-(4-methylphenyl)sul... 1 0
Receptor-type tyrosine-protein kinase FLT3 and NUAK family SNF... 1 1
Histone deacetylase 1 and HD2 type histone deacetylase HDA106 ... 1 2
D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 1
Pyridines and Derivatives Metabolite Rotundine A Family 1 0
Naphthyridines Metabolite 3-Acetyl-2,7-naphthyridine Family 1 4
Pyrrolizines Metabolite 2,3-Dihydro-5-methyl-1H-pyrrolizine-7-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00261003 CHEMBL2206838 Bioactive (4-iodonaphthalen-1-yl)-(1-pentylindol-3-yl)methanone
CFAMM00261020 CHEMBL557004 Bioactive JWH-122
CFAMM00261019 CHEMBL2206855 Bioactive (4-fluoronaphthalen-1-yl)-(1-pentylindol-3-yl)methanone
CFAMM00261009 CHEMBL549603 Bioactive JWH-210
CFAMM00261029 CHEMBL561013 Bioactive 1-Pentyl-3-(1-naphthoyl)indole
CFAMM00261007 CHEMBL564302 Bioactive (1-pentylindol-3-yl)-(4-propylnaphthalen-1-yl)methanone
CFAMM00261028 CHEMBL539994 Bioactive (7-ethylnaphthalen-1-yl)-(1-pentylindol-3-yl)methanone
CFAMM00261027 DNC006985 Investigative Drug JWH-363
CFAMM00261033 DNC006995 Investigative Drug JWH-365
CFAMM00261013 DNC006977 Investigative Drug JWH-348
CFAMM00261026 DNC006986 Investigative Drug JWH-246
CFAMM00261032 DNC006994 Investigative Drug JWH-373
CFAMM00261012 DNC006976 Investigative Drug JWH-309
CFAMM00261025 DNC006987 Investigative Drug JWH-368
CFAMM00261038 DNC006992 Investigative Drug JWH-307
CFAMM00261018 DNC007000 Investigative Drug JWH-156
CFAMM00261031 DNC006999 Investigative Drug JWH-150
CFAMM00261011 DNC006973 Investigative Drug JWH-370
CFAMM00261024 DNC006981 Investigative Drug JWH-371
CFAMM00261037 DNC006991 Investigative Drug JWH-369
CFAMM00261017 DNC006979 Investigative Drug JWH-308
CFAMM00261030 DNC006998 Investigative Drug JWH-145
CFAMM00261023 DNC006982 Investigative Drug JWH-364
CFAMM00261036 DNC006990 Investigative Drug JWH-372
CFAMM00261016 DNC006978 Investigative Drug JWH-245
CFAMM00261022 DNC006983 Investigative Drug JWH-244
CFAMM00261035 DNC006997 Investigative Drug JWH-147
CFAMM00261015 DNC006975 Investigative Drug JWH-347
CFAMM00261021 DNC006989 Investigative Drug JWH-346
CFAMM00261034 DNC006996 Investigative Drug JWH-146
CFAMM00261014 DNC006974 Investigative Drug JWH-366

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45918 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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