CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2148
Family Name Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-367 Family
No. of Seeds 14 No. of Other Members 214
Family Centroid CFAMM00261168 Functional Category Investigative Drug with Natural Product
Superfamily Cannabinoid receptor 2 and Aromatase Binder Superfamily
Class Class 656

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Phospholipase A2, membrane associated Inhibitor Varespladib Fa... 37 190
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Mast/stem cell growth factor receptor Kit and Vascular endothe... 1 4
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Vascular endothelial growth factor receptor 2 Ligand E 7080 Fa... 7 17
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
Indeglitazar family 3 39
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
Platelet-derived growth factor receptor alpha and Platelet-der... 2 13
RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Metabotropic glutamate receptor 1 Ligand JNJ-16259685 Family 3 20
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Fatty acid-binding protein, adipocyte Inhibitor 1-benzyl-2,3-d... 1 8
MO15-related protein kinase Pfmrk Inhibitor WR-289010 Family 2 506
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [4... 1 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 11
Endothelin-1 receptor and Endothelin B receptor ligand 3-(1,3-... 1 1
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 1 18
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 391
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 9 12
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-[3-cy... 2 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 3
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 8 12
Renin inhibitor AGN-PC-09M9MJ family 2 23
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
Ferritin light chain and Ras-related protein Rab-9A inhibitor ... 1 11
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... 2 9
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Glycylpeptide N-tetradecanoyltransferase 2 and Glycylpeptide N... 8 10
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 7
Histamine H3 receptor ligand SureCN2784306 family 5 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Prostaglandin D2 receptor 2 ligand SureCN137822 family 3 0
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 11 11
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 7 1
Serine/threonine-protein kinase B-raf inhibitor furan-based co... 6 3
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 5 12
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Phospholipase A2, membrane associated inhibitor AGN-PC-007MX4 ... 1 0
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Renin inhibitor [2-(3-fluoro-2,6-dimethylphenoxy)-1-phenylpyrr... 5 12
Retinoic acid receptor RXR-alpha ligand (E)-3-[3-(3,5-ditert-b... 5 5
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Integrase inhibitor (Z)-4-[1-[(4-fluorophenyl)methyl]-5-methox... 1 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 3 17
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Vascular endothelial growth factor receptor 2 and Vascular end... 2 52
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 4
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Cytosolic phospholipase A2 inhibitor AGN-PC-00BH8R family 6 13
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 3 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 7-met... 3 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 159
Fatty-acid amide hydrolase 1 inhibitor [3-(3-carbamoylpyrrol-1... 4 6
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
C-C chemokine receptor type 3 and Histamine H1 receptor ligand... 2 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 1 1
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 3
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Bifunctional epoxide hydrolase 2 inhibitor 8-(quinoline-5-carb... 1 0
Egl nine homolog 1 inhibitor 2-(2-methoxy-4-phenylphenyl)-8-[(... 1 0
Glutamate receptor ionotropic, NMDA 2B ligand SureCN5532501 fa... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 4 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 1 3
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 3
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 7 1
Platelet-activating factor receptor ligand N,N-dimethyl-6-phen... 12 18
Platelet-activating factor receptor ligand 5,6-dimethoxy-N,N-d... 2 3
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 1 4
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Cannabinoid receptor 1 ligand (4-hydroxynaphthalen-1-yl)-[1-(2... 2 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 2
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 1 8
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor AGN-... 1 3
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
CGMP-dependent protein kinase inhibitor AGN-PC-075IHL family 2 8
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PI... 4 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
72 kDa type IV collagenase and Aminopeptidase N inhibitor ly52... 1 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... 2 6
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 1 12
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 1 6
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
Mitogen-activated protein kinase 14 inhibitor (4E)-4-[3-amino-... 1 4
Cysteinyl leukotriene receptor 1 ligand 2-[2-[5-[[3-[(E)-2-(6,... 1 8
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Protein kinase C theta type and Protein kinase C delta type in... 13 0
Sodium-dependent serotonin transporter inhibitor SureCN5477150... 4 1
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Survival motor neuron protein and Arachidonate 15-lipoxygenase... 1 2
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 1
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 2 10
DNA-dependent protein kinase catalytic subunit inhibitor 2-mor... 1 4
Arachidonate 5-lipoxygenase inhibitor AGN-PC-071TED family 9 12
Bromodomain-containing protein 4 and Bromodomain-containing pr... 3 10
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(6aR... 1 0
Vascular endothelial growth factor receptor 2 ligand (4Z)-4-[(... 3 0
Histamine H1 receptor and Histamine H2 receptor ligand SureCN6... 1 3
Histamine H1 receptor and Histamine H2 receptor ligand SureCN5... 3 6
Mitogen-activated protein kinase 14 inhibitor Aminopyridine N-... 3 1
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 1 0
M-phase inducer phosphatase 2 and Dual specificity protein pho... 1 0
Cytosolic phospholipase A2 inhibitor SureCN3681683 family 3 0
Platelet-derived growth factor receptor beta and Vascular endo... 1 3
Aldose reductase inhibitor [1-(3,5-difluoro-4-hydroxyphenyl)py... 3 2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]... 1 0
Pol polyprotein inhibitor Phenprocoumon IndolEtCONH deriv. family 2 0
Indoleamine 2,3-dioxygenase 1 inhibitor CHEMBL576950 family 1 0
3-(1-acetylindol-3-yl)chromene-2,4-dione NP ZINC00518134 Family 2 0
1-[1-(furan-2-ylmethyl)-5-hydroxy-2-methylindol-3-yl]ethanone ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00261098 CHEMBL195838 Bioactive (4-methoxynaphthalen-1-yl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone
CFAMM00261076 CHEMBL552088 Bioactive (7-methoxynaphthalen-1-yl)-(1-pentylindol-3-yl)methanone
CFAMM00261228 CHEMBL564888 Bioactive JWH-098
CFAMM00261052 CHEMBL81473 Bioactive JWH-198
CFAMM00261243 DNC008717 Investigative Drug JWH-268
CFAMM00261242 DNC008715 Investigative Drug JWH-151
CFAMM00261169 DNC006980 Investigative Drug JWH-243
CFAMM00261234 DNC006993 Investigative Drug JWH-292
CFAMM00261168 DNC006988 Investigative Drug JWH-367

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27520 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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