CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2150
Family Name RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5-(4-hydroxy-2,6-dimethylstyryl)nicotinic Acid Family
No. of Seeds 3 No. of Other Members 7
Family Centroid CFAMM00261287 Functional Category Investigative Drug
Superfamily RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5-(4-hydroxy-2,6-dimethylstyryl)nicotinic Acid Superfamily
Class Class 2367

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Smoothened homolog Inhibitor LDE225 Family 3 76
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 5 23
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 13 26
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Renin Inhibitor CP-305202 Family 9 30
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand Isoqui... 1 6
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Endothelin-1 receptor and Endothelin B receptor ligand 3-(1,3-... 1 1
Leukotriene B4 receptor 1 ligand AGN-PC-04XM3V family 3 10
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 18
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
B2 bradykinin receptor ligand SureCN6640854 family 7 4
Cellular tumor antigen p53 and Lethal(3)malignant brain tumor-... 1 6
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Prostaglandin D2 receptor 2 ligand SureCN137822 family 3 0
Endothelin-1 receptor ligand SureCN8118632 family 4 5
Serine/threonine-protein kinase B-raf inhibitor furan-based co... 6 3
Retinoic acid receptor RXR-alpha ligand 6-[(3-butoxy-5,5,8,8-t... 2 2
Proteinase-activated receptor 1 ligand (3R,3aR,4S,5R,6S,7aS)-5... 2 3
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Pol polyprotein inhibitor Tertiary Amide deriv. 58 family 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor AGN-... 1 3
Thromboxane-A synthase inhibitor SureCN9045578 family 1 12
Glucocorticoid receptor ligand SureCN3894124 family 3 0
Beta-3 adrenergic receptor ligand SureCN5704018 family 4 1
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 0
DNA-dependent protein kinase catalytic subunit inhibitor 2-mor... 1 4
Neutrophil elastase inhibitor SureCN8210283 family 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00261284 CHEMBL220019 Bioactive 5-[(E)-2-[2,6-dimethyl-4-(methylcarbamoyloxy)phenyl]ethenyl]pyridine-3-carboxylic acid
CFAMM00261287 DNC007001 Investigative Drug 5-(4-hydroxy-2,6-dimethylstyryl)nicotinic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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