CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2151
Family Name Histamine H3 receptor Ligand N-benzyl-4-cyclopentylpiperazine-1-carboxamide Family
No. of Seeds 3 No. of Other Members 19
Family Centroid CFAMM00261308 Functional Category Investigative Drug
Superfamily Histamine H3 receptor Ligand N-benzyl-4-cyclopentylpiperazine-1-carboxamide Superfamily
Class Class 1148

Cousin Family NamesSeedsMembers
Sodium channel Ligand hydantoin derivative Phenytoin Family 2 25
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Sodium channel protein type 5 subunit alpha Ligand Mephenytoin... 5 51
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Acetylcholinesterase Inhibitor Ambenonium Family 4 71
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
C-X-C chemokine receptor type 4 Ligand AMD-3100 Family 3 6
Substance-P receptor Ligand Orvepitant Family 11 46
Voltage-gated sodium channel Ligand Lacosamide Family 1 10
Substance-P receptor Ligand Vestipitant Family 14 137
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Reverse transcriptase Inhibitor 3-benzylamino-5-ethyl-6-methyl... 2 24
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Glycogen synthase kinase-3 Inhibitor NP12 Family 3 5
Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... 18 168
Renin Inhibitor N-methyl-n-(methylbenzyl)formamide Family 2 17
Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phen... 3 12
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-[1-(4-isobut... 1 7
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Dipeptidyl peptidase 4 Inhibitor 2-(2-chlorophenyl)-2-morpholi... 2 34
Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... 10 22
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 11 6
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 2 7
Sodium-dependent serotonin transporter Inhibitor Irindalone Fa... 16 9
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 17 9
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 4 24
Aminopeptidase N Inhibitor 2-amino-n1-benzyl-n3-hydroxymalonam... 3 4
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 4 13
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 7 9
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 2 0
Survival motor neuron protein inhibitor CHEMBL1323700 family 1 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 0
Sigma non-opioid intracellular receptor 1 ligand (10aS)-2-(2-p... 1 2
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Sodium-dependent serotonin transporter and Sodium-dependent no... 9 0
Nociceptin receptor ligand 2-[3-[1-[(1R)-1,2-dihydroacenaphthy... 2 0
Histamine H3 receptor and Acetylcholinesterase ligand 1-[4-[[4... 1 2
P2X purinoceptor 7 inhibitor (4S)-3-methyl-N-[[2-methyl-3-(tri... 3 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 1
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 3 0
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 1 0
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 1
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor Su... 1 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 2
C-C chemokine receptor type 5 ligand AC1L9YPM family 3 6
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 1
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 1
Sodium-dependent noradrenaline transporter and Muscarinic acet... 1 2
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
Prostaglandin E synthase inhibitor AGN-PC-09QMEJ family 2 0
Prostaglandin E synthase inhibitor AGN-PC-09QIZR family 1 1
Histamine H3 receptor ligand (2S)-N-(2,3-dihydro-1H-inden-2-yl... 2 1
Melanin-concentrating hormone receptor 1 ligand 1-[[4-(4-fluor... 2 10
Urease inhibitor 1-$l^{1}-selanyl-N,N-dimethyl-N'-[(1S)-1-naph... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 7
Histamine H3 receptor ligand AGN-PC-077LOO family 1 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00261296 DNC014273 Investigative Drug N,4-dibenzhydrylpiperazine-1-carboxamide
CFAMM00261308 DNC007002 Investigative Drug N-benzyl-4-cyclopentylpiperazine-1-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27425 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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