CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2165
Family Name Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,2,9-trimethyl-9h-beta-carbolin-2-ium Family
No. of Seeds 4 No. of Other Members 2
Family Centroid CFAMM00261407 Functional Category Investigative Drug
Superfamily DNA Binder Elliptinium Acetate Superfamily
Class Class 770

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
DNA Binder Elliptinium Acetate Family 11 116
Citric Acid family 2 58
Apricoxib family 8 77
Indeglitazar family 3 39
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Plasminogen and Prothrombin Inhibitor 2-(2-hydroxy-phenyl)-1h-... 3 69
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Oestrogen receptor and Estrogen receptor beta Ligand ZK-119010... 2 16
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Serine/threonine-protein kinase Chk1 and Wee1-like protein kin... 2 101
Glycogen synthase kinase-3 beta Inhibitor 6-hydroxymanzamine A... 3 0
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3,3'-pyrazine-2,5-... 2 14
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 38 35
Androgen receptor Ligand 11-methyl-6,11-dihydro-5h-benzo[a]car... 7 9
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
Kinesin-like protein KIF11 inhibitor AGN-PC-080PZM family 1 11
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 10
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 2 10
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 2 0
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
5-hydroxytryptamine receptor 2C and Cytochrome P450 1A2 ligand... 6 4
Androgen receptor ligand (6R,7S)-6-ethyl-7-methyl-4-(trifluoro... 22 29
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Glucocorticoid receptor ligand AGN-PC-0A9RHA family 1 2
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00CFYH ... 2 1
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 1 1
Transient receptor potential cation channel subfamily V member... 1 5
Estrogen receptor beta and Estrogen receptor ligand 2-fluoro-4... 1 0
5-hydroxytryptamine receptor 2A ligand (3R,4R)-3-(2-phenyl-1H-... 1 18
Proto-oncogene tyrosine-protein kinase receptor Ret ligand Sur... 1 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aR... 3 6
Wee1-like protein kinase and Serine/threonine-protein kinase C... 8 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
Protein kinase C theta type and Protein kinase C delta type in... 10 7
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 7 1
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aS... 2 1
Androgen receptor ligand SureCN1990713 family 1 0
Kinesin-like protein KIF11 inhibitor AGN-PC-07R5ZC family 1 5
Aldose reductase and Aldo-keto reductase family 1 member B10 i... 1 2
Indoles Metabolite 4-[N-(p-Coumaroyl)serotonin-4''-yl]-N-ferul... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00261406 CHEMBL197585 Bioactive DATELLIPTIUM
CFAMM00261408 DNC007089 Investigative Drug 6-hydroxy-2,9-dimethyl-9H-beta-carbolin-2-ium
CFAMM00261407 DNC007087 Investigative Drug 6-hydroxy-1,2,9-trimethyl-9H-beta-carbolin-2-ium
CFAMM00261405 DNC008563 Investigative Drug 8-Hydroxy-5,7,9-trimethyl-delta-carboline

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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