CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2166
Family Name Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-4-carbohydrazide Family
No. of Seeds 14 No. of Other Members 33
Family Centroid CFAMM00261449 Functional Category Investigative Drug with Natural Product
Superfamily Neuromedin-K receptor Ligand Talnetant Superfamily
Class Class 297

Cousin Family NamesSeedsMembers
HIV protease Inhibitor Saquinavir Family 64 428
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Egl nine homolog 2 Inhibitor FG-4592 Family 1 4
Neuromedin-K receptor Ligand SB222200 Family 17 235
Neuromedin-K receptor Ligand Talnetant Family 3 49
Dihydroorotate dehydrogenase Inhibitor Brequinar Family 9 122
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
D(3) dopamine receptor Ligand SB-277011 Family 13 178
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
Setipiprant family 5 118
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
C-C chemokine receptor type 2 and C-C motif chemokine 2 Ligand... 3 52
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Melatonin receptor type 1B Ligand N-(3-benzooxazol-7-yl-propyl... 26 101
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 1 4
Fatty-acid amide hydrolase 1 Inhibitor 3-(benzo[d]oxazol-2-yl)... 1 6
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
Neuromedin-K receptor and Substance-K receptor ligand 2-[2-phe... 2 2
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[3-(1,3-be... 3 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 21
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 3 28
B2 bradykinin receptor ligand (E)-N-[2-[2,4-dimethoxy-N-methyl... 3 2
B2 bradykinin receptor ligand 2-(4-aminobutylcarbamoylamino)-N... 5 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ... 2 7
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
Renin inhibitor SureCN1144364 family 3 15
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Renin inhibitor AGN-PC-09M9MJ family 2 23
5-hydroxytryptamine receptor 3A ligand 2-[(3S)-3-ethylmorpholi... 10 18
Cysteinyl leukotriene receptor 1 ligand SureCN7808360 family 4 11
Cysteinyl leukotriene receptor 1 ligand SureCN9053715 family 2 11
B2 bradykinin receptor ligand SureCN7012818 family 1 2
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
B2 bradykinin receptor ligand 4-[(E)-3-[[2-[2,4-dichloro-3-[[4... 29 2
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 4
B2 bradykinin receptor ligand SureCN8516699 family 3 2
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... 2 9
Thyroid hormone receptor beta ligand CHEMBL1397256 family 1 12
B2 bradykinin receptor ligand SureCN6640854 family 7 4
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 2 6
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 16 5
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 4 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 5
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Cysteinyl leukotriene receptor 1 and Peripheral myelin protein... 1 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 3 0
Melanin-concentrating hormone receptor 1 ligand N-[3-(2-aminoq... 4 1
Renin inhibitor [2-(2,6-dimethylphenoxy)-6-methoxy-1-phenylpyr... 1 0
Renin inhibitor [2-(3-fluoro-2,6-dimethylphenoxy)-1-phenylpyrr... 5 12
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FSU ... 1 1
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
Pol polyprotein inhibitor (2S)-N-[4-[cyclopentyloxy-(4-methoxy... 1 0
NS5B protein inhibitor AC1O5AET family 3 1
Renin and Potassium voltage-gated channel subfamily H member 2... 4 0
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and Dual 3',5'... 27 20
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Cholinesterase and Acetylcholinesterase inhibitor 4-oxo-N-[9-(... 11 13
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 12 3
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-2-[(4-fluo... 7 1
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[(1... 2 0
Hematopoietic prostaglandin D synthase inhibitor 4-(3-methylis... 1 7
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Plasmepsin-2 and Cathepsin D inhibitor 4-[4-[[(2S,3S)-1-[[(3S,... 3 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Sonic hedgehog protein inhibitor 3-methoxy-1-methyl-4-oxo-5-ph... 5 3
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 7-met... 3 2
Acetylcholinesterase and Butyrylcholinesterase inhibitor (E)-3... 4 5
Cholinesterase and Acetylcholinesterase inhibitor tacrine deri... 10 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
Cholinesterase and Acetylcholinesterase inhibitor 6-[2-methoxy... 12 6
Prostaglandin E synthase inhibitor 3-[4-(3-cyanopropoxy)-3-met... 2 4
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Cholinesterase and Acetylcholinesterase inhibitor 6-[4-[2-fluo... 17 0
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Disintegrin and metalloproteinase domain-containing protein 17... 5 4
Bifunctional epoxide hydrolase 2 inhibitor 8-(quinoline-5-carb... 1 0
5-hydroxytryptamine receptor 4 and Potassium voltage-gated cha... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 19 11
Plasmepsin-2 and Cathepsin D inhibitor N'-(3,4-dimethylacridin... 1 3
Disintegrin and metalloproteinase domain-containing protein 17... 8 0
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 7-met... 2 1
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 2
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... 1 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PI... 4 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
B2 bradykinin receptor ligand (E)-N-[2-[N-methyl-3-[(2-methylq... 2 0
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 3
Prothrombin inhibitor AGN-PC-074I2Z family 2 1
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Beta-1 adrenergic receptor and Beta-3 adrenergic receptor liga... 1 5
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 1 0
ATP-dependent molecular chaperone HSP82 and Arachidonate 12-li... 1 2
Oxysterols receptor LXR-beta ligand indole derivative, 39 family 2 0
Potassium-transporting ATPase alpha chain 1 and Potassium-tran... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00261444 CHEMBL2113681 Bioactive 2-phenyl-N-[(1S)-1-phenylpropyl]-3-(2-pyrrolidin-1-ylethoxy)quinoline-4-carboxamide
CFAMM00261451 CHEMBL2113678 Bioactive 3-[2-(dimethylamino)ethoxy]-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide
CFAMM00261430 CHEMBL221016 Bioactive AGN-PC-00CCSL
CFAMM00261456 CHEMBL219162 Bioactive methyl N-[(3-methoxy-2-phenylquinoline-4-carbonyl)amino]-N-phenylcarbamate
CFAMM00261413 CHEMBL374354 Bioactive 3-methoxy-N',N',2-triphenylquinoline-4-carbohydrazide
CFAMM00261441 CHEMBL9645 Bioactive AGN-PC-050TNU
CFAMM00261454 CHEMBL2113677 Bioactive 3-(2-amino-2-oxoethoxy)-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide
CFAMM00261433 CHEMBL274629 Bioactive 3-[2-(dimethylamino)-2-oxoethoxy]-2-phenyl-N-[(1R)-1-phenylpropyl]quinoline-4-carboxamide
CFAMM00261426 CHEMBL218421 Bioactive methyl N-[(8-fluoro-3-methoxy-2-phenylquinoline-4-carbonyl)amino]-N-phenylcarbamate
CFAMM00261453 CHEMBL2113676 Bioactive 3-[3-(dimethylamino)propoxy]-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide
CFAMM00261452 CHEMBL2113679 Bioactive 3-(2-aminoethoxy)-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide
CFAMM00261449 DNC007097 Investigative Drug 3-methoxy-N',2-diphenylquinoline-4-carbohydrazide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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