CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2187
Family Name Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-methoxy-2-[(4-methoxyphenyl)ethynyl]adenosine Family
No. of Seeds 21 No. of Other Members 57
Family Centroid CFAMM00261979 Functional Category Investigative Drug with Natural Product
Superfamily Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-methoxy-2-[(4-methoxyphenyl)ethynyl]adenosine Superfamily
Class Class 1289

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
P2Y purinoceptor 12 Inhibitor Brilinta Family 1 1
Pigment epithelium-derived factor Inhibitor Adpedr Family 2 112
Adenosine receptor A3 Ligand CF101 Family 24 560
Adenosine receptor A2a Ligand MRE-0094 Family 10 108
GP-531 family 1 33
C-Jun N-terminal kinase Inhibitor CC-930 Family 2 9
Tyrosine kinase Inhibitor PKI166 Family 17 198
Equilibrative nucleoside/nucleobase transporter Inhibitor Nitr... 23 98
Poly [ADP-ribose] polymerase 1 Inhibitor EB-47 Family 17 41
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 7
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 7 72
Estradiol 17-beta-dehydrogenase 1 Inhibitor EM-1745 Family 2 10
Peptide deformylase, mitochondrial Inhibitor 8-(2,3,4-trimetho... 8 15
Adenosine receptor A1 and Adenosine receptor A2a Ligand GW-328... 26 94
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-[(4-... 15 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 12 5
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 2 2
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 2 3
Adenosine receptor A2a and Adenosine receptor A3 Ligand 2-(3''... 8 10
Serine/threonine-protein kinase mTOR Inhibitor (4-(6-morpholin... 2 11
Inositol 1,4,5-trisphosphate receptor type 3 Ligand 5'-deoxy-5... 11 8
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Adenosine kinase inhibitor GP683 family 12 7
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Proto-oncogene tyrosine-protein kinase Src and Cyclin-dependen... 2 1
Adenosine receptor A3 and Adenosine receptor A1 ligand (2S,3S,... 2 9
Adenosine receptor A3 and Adenosine receptor A1 ligand (2S,3S,... 3 0
Adenosine receptor A3 and Adenosine receptor A1 ligand (2R,3S,... 1 2
Uracil nucleotide/cysteinyl leukotriene receptor ligand azane;... 1 0
Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) ... 24 9
Adenosine receptor A3 ligand SureCN6211758 family 5 10
Adenosine receptor A1 and Adenosine receptor A2a ligand (2S,3S... 2 16
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase inh... 7 6
S-methyl-5'-thioadenosine phosphorylase inhibitor SureCN997478... 8 0
Adenosine receptor A3 and Adenosine receptor A2a ligand (1R,2R... 12 17
Adenosine kinase inhibitor N-cyclopropyl-2-[[1-[(2R,3R,4S,5R)-... 4 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Proto-oncogene tyrosine-protein kinase Src and Epidermal growt... 9 9
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 0
Adenosine receptor A1 ligand N-[(2R,3R,4R,5R)-5-[6-(cyclopenty... 3 2
Adenosine kinase inhibitor 2-[[7-[(2R,3R,4S,5R)-3,4-dihydroxy-... 15 0
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Adenosine kinase inhibitor SureCN8320660 family 7 2
Adenosine receptor A3 and Adenosine receptor A1 ligand (2S,3S,... 8 10
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
Adenosine receptor A3 and Adenosine receptor A1 ligand (2S,3S,... 6 17
Adenosine receptor A3 and Adenosine receptor A1 ligand (2S,3S,... 2 0
Adenosine receptor A3 ligand (1R,2R,3S,4R,5S)-4-[2-[2-(2-chlor... 5 1
Adenosine receptor A3 and Adenosine receptor A1 ligand (1S,2R,... 6 0
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 11 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Adenosine receptor A3 and Adenosine receptor A1 ligand (2S,3S,... 7 4
Nitric oxide synthase, inducible inhibitor SureCN5194847 family 24 48
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 11 1
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Adenosine receptor A3 ligand (2R,3R,4S)-2-[2-chloro-6-[(3-fluo... 6 7
Adenosine receptor A3 ligand (2R,3R,4S)-2-[6-[(3-bromophenyl)m... 3 0
Adenosine receptor A1 and Adenosine receptor A3 ligand N-benzy... 4 2
Adenosine receptor A1 ligand 2-[4-[[2-[4-[[9-[(3R,4S,5R)-3,4-d... 14 0
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Adenosine receptor A1 ligand 3-chloro-N-[(2S,3R,4R,5R)-5-[6-(c... 1 0
Adenosine receptor A1 ligand N-[(2R,3R,4R,5R)-5-[6-(cyclopenty... 3 3
Adenosine receptor A2a and Adenosine receptor A2b ligand Cgs-2... 1 2
P2X purinoceptor 1 and P2X purinoceptor 3 inhibitor [(2R,3R,4R... 1 5
Adenosine receptor A3 and Adenosine receptor A1 ligand (2R,3R,... 1 0
Adenosine receptor A1 and Adenosine receptor A3 ligand ethyl 4... 2 0
Adenosine receptor A1 ligand (2,5-dioxopyrrolidin-1-yl) 2-[4-[... 3 0
Adenosine receptor A1 ligand (2-bromophenyl)methyl (1S,3R,4S)-... 1 0
Adenosine receptor A3 and Adenosine receptor A2a ligand (1R,2R... 2 0
Adenosine receptor A2a and Adenosine receptor A3 ligand SureCN... 4 3
Adenosine receptor A1 ligand 2-[4-[[2-[4-[[9-[(3R,4S,5R)-3,4-d... 1 0
Adenosine receptor A2a and Adenosine receptor A2b ligand (3S,4... 3 2
Adenosine receptor A2a and Adenosine receptor A2b ligand (3R,4... 7 3
Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) ... 30 0
Adenosine receptor A1 and Adenosine receptor A2b ligand (2R,3R... 1 0
P2Y purinoceptor 12 inhibitor [(3aR,4R,6R,6aR)-4-[6-(ethylcarb... 2 4
Serine/threonine-protein kinase Chk2 inhibitor (6E)-4-fluoro-6... 3 6
DNA polymerase III PolC-type and DNA polymerase III subunit al... 11 10
Equilibrative nucleoside transporter 1 inhibitor methyl 4-[[9-... 1 3
78 kDa glucose-regulated protein inhibitor 4-[[(2R,3S,4R,5R)-5... 1 0
78 kDa glucose-regulated protein and Heat shock cognate 71 kDa... 1 0
Cholinesterase inhibitor [(3S,3aS,4R,5R,7R,7aR)-7-(2-acetamido... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00261929 CHEMBL611610 Bioactive (3R,4S,5R)-2-[6-amino-2-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazinyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
CFAMM00261943 CHEMBL410115 Bioactive (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[2-[(3R)-3-hydroxy-3-phenylprop-1-ynyl]-6-(methylamino)purin-9-yl]oxolane-3,4-diol
CFAMM00261926 CHEMBL604422 Bioactive (3S,4R,5S)-2-[6-amino-2-[2-(3-methoxyphenyl)ethoxy]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
CFAMM00261948 CHEMBL605465 Bioactive (3S,4R,5S)-2-[6-amino-2-[2-(3,4-dimethoxyphenyl)ethoxy]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
CFAMM00261917 CHEMBL410095 Bioactive (2R,3R,4S,5R)-2-[6-(ethylamino)-2-[(3R)-3-hydroxy-3-phenylprop-1-ynyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
CFAMM00261933 CHEMBL2368675 Bioactive (2R,3R,4S,5R)-2-[6-[[(2R)-1-(4-hydroxy-3-iodophenyl)propan-2-yl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
CFAMM00261947 CHEMBL605463 Bioactive (3S,4R,5S)-2-[6-amino-2-[2-(4-methoxyphenyl)ethoxy]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
CFAMM00261915 CHEMBL2092941 Bioactive SureCN4538178
CFAMM00261963 CHEMBL191809 Bioactive SureCN640022
CFAMM00261979 DNC007150 Investigative Drug N6-methoxy-2-[(4-methoxyphenyl)ethynyl]adenosine
CFAMM00261930 DNC013250 Investigative Drug N6-(4-hydroxybenzyl)adenine riboside

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27513 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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