CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2198
Family Name Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''-indolylethyloxy)adenosine Family
No. of Seeds 12 No. of Other Members 5
Family Centroid CFAMM00262169 Functional Category Investigative Drug
Superfamily Adenosine receptor A1 and Adenosine receptor A2a Binder Superfamily 6
Class Class 860

Cousin Family NamesSeedsMembers
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Pigment epithelium-derived factor Inhibitor Adpedr Family 2 112
Adenosine receptor A3 Ligand CF101 Family 24 560
Adenosine receptor A2a Ligand MRE-0094 Family 10 108
Adenosine receptor A1 Ligand SLV320 Family 6 79
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
C-Jun N-terminal kinase Inhibitor CC-930 Family 2 9
Equilibrative nucleoside/nucleobase transporter Inhibitor Nitr... 23 98
Poly [ADP-ribose] polymerase 1 Inhibitor EB-47 Family 17 41
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 7
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 7 72
Adenosine receptor A1 and Adenosine receptor A2a Ligand GW-328... 26 94
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 21 57
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-[(4-... 15 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 2 2
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 2 3
Adenosine receptor A2a and Adenosine receptor A3 Ligand 2-(3''... 8 10
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Inositol 1,4,5-trisphosphate receptor type 3 Ligand 5'-deoxy-5... 11 8
Adenosine kinase inhibitor GP683 family 12 7
Adenosine receptor A3 and Adenosine receptor A1 ligand (2R,3S,... 1 2
Uracil nucleotide/cysteinyl leukotriene receptor ligand azane;... 1 0
Purine nucleoside phosphorylase inhibitor 7-[(3R,4S,5R)-3,4-di... 10 34
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase inh... 17 17
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase inh... 7 6
S-methyl-5'-thioadenosine phosphorylase inhibitor SureCN997478... 8 0
Adenosine receptor A3 and Adenosine receptor A2a ligand (1R,2R... 12 17
Adenosine kinase inhibitor N-cyclopropyl-2-[[1-[(2R,3R,4S,5R)-... 4 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Adenosine deaminase inhibitor AGN-PC-00FYYU family 4 5
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Adenosine receptor A1 ligand N-[(2R,3R,4R,5R)-5-[6-(cyclopenty... 3 2
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
Adenosine kinase inhibitor 2-[[7-[(2R,3R,4S,5R)-3,4-dihydroxy-... 15 0
Adenosine kinase inhibitor SureCN8320660 family 7 2
Adenosine receptor A3 and Adenosine receptor A1 ligand (2S,3S,... 2 0
Activated CDC42 kinase 1 inhibitor N,N-dimethyl-4-[4-[[(2S)-ox... 4 2
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family 8 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Tyrosine-protein kinase JAK1 and Non-receptor tyrosine-protein... 7 0
Adenosine receptor A3 and Adenosine receptor A1 ligand (2S,3S,... 2 10
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Adenosine receptor A3 ligand (2R,3R,4S)-2-[2-chloro-6-[(3-fluo... 6 7
Adenosine receptor A1 and Adenosine receptor A3 ligand N-benzy... 4 2
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
Adenosine receptor A1 ligand 2-[4-[[2-[4-[[9-[(3R,4S,5R)-3,4-d... 14 0
Adenosylhomocysteinase inhibitor Carbocyclic 3-deazaadenosine ... 1 0
Adenosine receptor A2a and Adenosine receptor A2b ligand Cgs-2... 1 2
Adenosine receptor A1 ligand (2,5-dioxopyrrolidin-1-yl) 2-[4-[... 3 0
Adenosine receptor A1 ligand (2-bromophenyl)methyl (1S,3R,4S)-... 1 0
Adenosine receptor A2a and Adenosine receptor A3 ligand SureCN... 4 3
78 kDa glucose-regulated protein inhibitor 4-[[(2R,3S,4R,5R)-5... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00262162 CHEMBL605256 Bioactive (3S,4R,5S)-2-[6-amino-2-[2-(1H-indol-3-yl)ethoxy]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
CFAMM00262167 DNC007207 Investigative Drug 2-(3''-(5''-bromo-indolyl)ethyloxy)adenosine
CFAMM00262173 DNC007211 Investigative Drug 2-(3''-(4''-bromo-indolyl)ethyloxy)adenosine
CFAMM00262166 DNC007202 Investigative Drug 2-(2''-indolylethyloxy)adenosine
CFAMM00262172 DNC007215 Investigative Drug 6-guanidino-2-(3''-indolylethyloxy)adenosine
CFAMM00262165 DNC007208 Investigative Drug 2-(3''(5''-chloro-indolyl)ethyloxy)adenosine
CFAMM00262171 DNC007214 Investigative Drug 6-ethylamino-2-(3''-indolyl)ethyloxy)adenosine
CFAMM00262164 DNC007209 Investigative Drug 2-(3''-(5''-fluoro-indolyl)ethyloxy)adenosine
CFAMM00262176 DNC007210 Investigative Drug 2-(3''(7''-bromo-indolyl)ethyloxy)adenosine
CFAMM00262169 DNC007204 Investigative Drug 2-(3''-indolylethyloxy)adenosine
CFAMM00262168 DNC007206 Investigative Drug 2-(3''-(5''-iodo-indolyl)ethyloxy)adenosine
CFAMM00262174 DNC007212 Investigative Drug 2-(3''-(6''-bromo-indolyl)ethyloxy)adenosine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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