CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2200
Family Name Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''-(5''-hydroxyindolyl)ethyloxy)adenosine Family
No. of Seeds 2 No. of Other Members 3
Family Centroid CFAMM00262185 Functional Category Investigative Drug with Natural Product
Superfamily Adenosine receptor A1 and Adenosine receptor A2a Binder Superfamily 6
Class Class 860

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Adenosine receptor A3 Ligand CF101 Family 24 560
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
Adenosine receptor A2a Ligand MRE-0094 Family 10 108
Adenosine receptor A1 Ligand SLV320 Family 6 79
SB1518 family 7 103
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Poly [ADP-ribose] polymerase 1 Inhibitor EB-47 Family 17 41
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 7
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 7 72
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Adenosine receptor A1 and Adenosine receptor A2a Ligand GW-328... 26 94
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 21 57
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-[(4-... 15 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 12 5
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 2 2
Adenosine receptor A2a and Adenosine receptor A3 Ligand 2-(3''... 8 10
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Inositol 1,4,5-trisphosphate receptor type 3 Ligand 5'-deoxy-5... 11 8
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Adenosine kinase inhibitor GP683 family 12 7
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 7 5
S-methyl-5'-thioadenosine phosphorylase inhibitor SureCN997478... 8 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
Adenosine kinase inhibitor N-cyclopropyl-2-[[1-[(2R,3R,4S,5R)-... 4 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Epidermal growth factor receptor ligand Pyrimido[4,5-b]indole ... 1 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 7 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
Adenosine kinase inhibitor 2-[[7-[(2R,3R,4S,5R)-3,4-dihydroxy-... 15 0
Adenosine kinase inhibitor SureCN8320660 family 7 2
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Adenosine receptor A3 and Adenosine receptor A1 ligand (2S,3S,... 6 17
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 11 4
Tyrosine-protein kinase JAK1 and Non-receptor tyrosine-protein... 7 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Adenosine receptor A1 and Adenosine receptor A3 ligand N-benzy... 4 2
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 12 2
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
Adenosine receptor A1 ligand 2-[4-[[2-[4-[[9-[(3R,4S,5R)-3,4-d... 14 0
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... 5 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 0
Adenosine receptor A3 and Adenosine receptor A1 ligand (2R,3R,... 1 0
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... 1 2
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 15 1
Cathepsin S and Cathepsin K inhibitor 2-cyano-pyrropyrimidine,... 4 1
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Adenosine receptor A3 and Adenosine receptor A2a ligand (1R,2R... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Adenosine receptor A1 ligand 2-[4-[[2-[4-[[9-[(3R,4S,5R)-3,4-d... 1 0
Adenosine receptor A1 and Adenosine receptor A2b ligand (2R,3R... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
78 kDa glucose-regulated protein inhibitor 4-[[(2R,3S,4R,5R)-5... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00262186 DNC007217 Investigative Drug 2-(3''-(5''-methoxy-indolyl)ethyloxy)adenosine
CFAMM00262185 DNC007216 Investigative Drug 2-(3''-(5''-hydroxyindolyl)ethyloxy)adenosine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26843 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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