CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2226
Family Name Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6-diphenylpyrimidin-4-yl)butyramide Family
No. of Seeds 22 No. of Other Members 18
Family Centroid CFAMM00262331 Functional Category Investigative Drug with Natural Product
Superfamily Adenosine receptor A1 and Adenosine receptor A2a Binder Superfamily 7
Class Class 824

Cousin Family NamesSeedsMembers
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 16 295
Neuropeptide Y receptor type 5 Ligand CGP71683A Family 5 74
Transient receptor potential cation channel subfamily V member... 15 457
Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-6... 28 56
Mitogen-activated protein kinase 12 Inhibitor VX-702 Family 3 49
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Reverse transcriptase Inhibitor Dapivirine Family 5 72
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
GDC-0349 family 44 77
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
Toll-like receptor 7 Ligand GS-9620 Family 2 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
D(4) dopamine receptor Ligand L-745,870 Family 30 205
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... 5 14
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 1,3-... 7 2
Epidermal growth factor receptor Ligand N*4*-(3-bromo-phenyl)-... 7 11
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... 7 5
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Adenosine receptor A1 and Adenosine receptor A2a Ligand 3-benz... 1 6
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
Poly [ADP-ribose] polymerase 1 Inhibitor 2-ethylquinoline-8-ca... 3 4
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Metabotropic glutamate receptor 5 Ligand 3-chloro-n-(6-chlorop... 2 5
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(6-methylpy... 4 3
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Adenosine receptor A1 Ligand N-(4,6-diphenylpyrimidin-2-yl)ben... 4 8
Adenosine receptor A3 Ligand 2-aminoquinazoline-4-carboxyanili... 4 3
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 9 24
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Prostaglandin G/H synthase 2 Inhibitor GW-637185X Family 27 48
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Urotensin-2 receptor Ligand Palosuran Family 4 4
Metabotropic glutamate receptor 5 Ligand N-(1,3-diphenyl-1h-py... 6 37
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Metabotropic glutamate receptor 5 Ligand 2-methyl-7-m-tolyl-1,... 5 2
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Prothrombin inhibitor SureCN5856722 family 3 16
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 3
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 1 7
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-(4-cy... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Cathepsin K and Potassium voltage-gated channel subfamily H me... 5 1
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family 10 8
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Glucosylceramidase and Alpha-galactosidase A inhibitor AC1NNEG... 4 5
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
Survival motor neuron protein inhibitor CHEMBL1581561 family 1 3
Survival motor neuron protein inhibitor CHEMBL1583999 family 1 3
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Toll-like receptor 7 ligand 6-amino-2-(butylamino)-9-[[4-(dime... 5 4
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Neuropeptide Y receptor type 5 ligand SureCN8898853 family 2 3
Dihydrofolate reductase inhibitor 1-[3-(2,4-diaminoquinazolin-... 2 4
Beta-secretase 1 inhibitor 3-[2-amino-6-(2-methylphenyl)quinol... 5 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 0
Dipeptidyl peptidase 4 inhibitor Aminomethylpyrimidine 1ck family 6 3
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 3 0
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 4
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 2
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 2 0
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 4 8
Serine/threonine-protein kinase TBK1 and 3-phosphoinositide-de... 3 3
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Fatty-acid amide hydrolase 1 inhibitor 4-(3-phenyl-1,2,4-thiad... 2 1
G-protein coupled bile acid receptor 1 ligand 2-(ethylamino)-6... 5 4
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Histamine H4 receptor and Histamine H3 receptor ligand 7-cyclo... 2 0
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 3 0
Mast/stem cell growth factor receptor Kit and Proto-oncogene t... 3 5
Proto-oncogene tyrosine-protein kinase Src and Mast/stem cell ... 4 1
Tyrosine-protein kinase JAK2 inhibitor N-(3-methylphenyl)-5-(3... 2 4
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... 3 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 6 6
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 7
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 11 1
Transient receptor potential cation channel subfamily V member... 3 2
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... 4 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-[2-(3-hydroxypr... 2 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 3 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Dihydrofolate reductase inhibitor N-(2,4-diamino-5-methylquina... 2 0
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0
P2Y purinoceptor 14 inhibitor AGN-PC-0A9S8H family 3 2
Diacylglycerol O-acyltransferase 1 inhibitor 2-[4-[4-(4-amino-... 2 3
Corticotropin-releasing factor receptor 1 ligand 5-N,5-N-bis(c... 2 0
Glucocorticoid receptor ligand 5-[(6-methylpyridin-2-yl)methyl... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00262318 CHEMBL1650349 Bioactive AGN-PC-08WSLK
CFAMM00262337 CHEMBL222504 Bioactive LUF-5764
CFAMM00262325 DNC007286 Investigative Drug N-(2,6-diphenylpyrimidin-4-yl)isobutyramide
CFAMM00262331 DNC007288 Investigative Drug N-(2,6-diphenylpyrimidin-4-yl)butyramide
CFAMM00262351 DNC007276 Investigative Drug pentanoic acid (4,6-diphenylpyrimidin-2-yl)amide
CFAMM00262324 DNC007287 Investigative Drug hexanoic Acid (2,6-diphenylpyrimidin-4-yl)amide
CFAMM00262340 DNC007290 Investigative Drug N-(2,6-diphenylpyrimidin-4-yl)acetamide
CFAMM00262330 DNC007289 Investigative Drug N-(2,6-diphenylpyrimidin-4-yl)propionamide
CFAMM00262317 DNC007274 Investigative Drug N-(4,6-diphenylpyrimidin-2-yl)-3-methylbutyramide
CFAMM00262350 DNC007273 Investigative Drug N-(4,6-diphenylpyrimidin-2-yl)-2-ethylbutyramide
CFAMM00262323 DNC007282 Investigative Drug LUF-5764
CFAMM00262349 DNC007278 Investigative Drug N-(4,6-diphenylpyrimidin-2-yl)propionamide
CFAMM00262322 DNC007283 Investigative Drug LUF-5767
CFAMM00262327 DNC007284 Investigative Drug N-(2,6-diphenylpyrimidin-4-yl)-2-ethylbutyramide
CFAMM00262333 DNC007277 Investigative Drug LUF-5735
CFAMM00262326 DNC007285 Investigative Drug N-(2,6-diphenylpyrimidin-4-yl)-3-methylbutyramide
CFAMM00262319 DNC007279 Investigative Drug N-(4,5-diphenylpyrimidin-2-yl)acetamide
CFAMM00262352 DNC007275 Investigative Drug LUF-5737

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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