CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2234
Family Name Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone Family
No. of Seeds 3 No. of Other Members 33
Family Centroid CFAMM00262511 Functional Category Investigative Drug with Natural Product
Superfamily Amyloid beta A4 protein and Amine oxidase [flavin-containing] A Binder Superfamily
Class Class 281

Cousin Family NamesSeedsMembers
Beta-1 adrenergic receptor Ligand Acebutolol Family 2 27
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Vitamin K epoxide reductase complex subunit 1 Inhibitor Acenoc... 2 46
D(4) dopamine receptor Ligand PD-165167 Family 2 96
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Mitogen-activated protein kinase kinase kinase 1 and Mitogen-a... 1 0
Arachidonate 5-lipoxygenase Inhibitor ZM-230487 Family 3 23
Peptidyl-prolyl cis-trans isomerase A Inhibitor 7-amino-4-meth... 4 59
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 4-(2... 4 31
Cytochrome P450 1B1 Inhibitor N-(2,4-dimethoxy-phenyl)-3,5-dim... 1 110
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Oxysterols receptor LXR-alpha Ligand N-{4-[2-(4-methoxyphenyl)... 3 16
Amyloid beta A4 protein Inhibitor 5-hydroxy-2-(4-methylaminoph... 6 71
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
D(2) dopamine receptor Ligand Epidepride Family 31 66
Metabotropic glutamate receptor 5 Ligand N-(3-(3-cyanobenzamid... 2 13
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Gamma-aminobutyric acid receptor Ligand 2-(2-amino-phenyl)-6-m... 4 23
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Acetylcholinesterase inhibitor trimethyl-(2-methyl-3-propanoyl... 3 2
Multidrug resistance protein 1 inhibitor 1-[2-[(2R)-3-[4-(2,3-... 2 41
Nuclear receptor ROR-gamma and Menin ligand CHEMBL1432265 family 1 18
Acrosin and Trypsin-1 inhibitor (4-methylphenyl) 4-(diaminomet... 10 13
Trace amine-associated receptor 1 ligand EPPTB family 4 9
Histamine H3 receptor ligand SureCN2785624 family 2 0
Histamine H3 receptor ligand 5-[4-[3-[(2R)-2-methylpyrrolidin-... 2 3
Histamine H3 receptor ligand N-[[2-[2-[(2R)-2-methylpyrrolidin... 4 1
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 1 2
Sphingosine 1-phosphate receptor 1 ligand 2-methoxy-N-[(4-phen... 2 23
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 5
Delta-type opioid receptor and Kappa-type opioid receptor liga... 5 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 5
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 2
Lanosterol synthase inhibitor AGN-PC-07BZTC family 1 3
Amyloid beta A4 protein inhibitor 2-(fluoranylmethyl)-3-[4-[(E... 1 3
Acetylcholinesterase and Butyrylcholinesterase inhibitor 6,7-d... 1 29
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Retinoic acid receptor RXR-gamma and Retinoic acid receptor RX... 3 36
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 2 9
Amine oxidase [flavin-containing] B and Adenosine receptor A2b... 2 2
Caspase-3 inhibitor AGN-PC-00ELYM family 3 2
Mitogen-activated protein kinase 14 inhibitor SureCN4222090 fa... 1 12
Cathepsin K and Cathepsin B inhibitor N-[1-[[cyano(methyl)amin... 1 1
Dual specificity mitogen-activated protein kinase kinase 1 inh... 8 3
Dual specificity mitogen-activated protein kinase kinase 1 inh... 9 1
Dual specificity mitogen-activated protein kinase kinase 1 inh... 3 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 1 1
Progesterone receptor ligand AGN-PC-00PB7I family 1 5
Thioredoxin glutathione reductase and Microtubule-associated p... 1 2
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Nuclear receptor ROR-gamma and Retinal dehydrogenase 1 ligand ... 1 8
Cytochrome P450 2D6 inhibitor 2-[(3-butoxyphenoxy)methyl]-3-me... 1 0
2-carboxy-5-[[(E)-3-(4-methoxyphenyl)-3-oxoprop-1-enyl]amino]p... 1 0
N-(4-acetamidophenyl)-2-(2,2-dimethyl-3,4-dihydrochromen-6-yl)... 1 0
2-[4-(dimethylamino)benzylidene]-6-methoxybenzo[de]chromen-3(2... 1 0
Putative NP ZINC09660203 Family 15 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00262523 CHEMBL452001 Bioactive AC1O784T
CFAMM00262528 DNC007315 Investigative Drug 6-iodo-4'-dimethyaminoflavone
CFAMM00262511 DNC007312 Investigative Drug 6-iodo-4'-methylaminoflavone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27513 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543