CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2239
Family Name Voltage-dependent T-type calcium channel subunit alpha-1I Ligand KKHT-20818 Family
No. of Seeds 7 No. of Other Members 35
Family Centroid CFAMM00262639 Functional Category Investigative Drug with Natural Product
Superfamily Voltage-dependent T-type calcium channel subunit alpha-1I Ligand KKHT-20818 Superfamily
Class Class 1375

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Alpha adrenergic receptor Ligand Droperidol Family 20 244
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Integrin alpha-4 Inhibitor R1295 Family 18 59
Kinesin-like protein KIF11 Inhibitor Ispinesib Family 4 37
Motilin receptor Ligand GSK962040 Family 30 457
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
K-604 family 4 71
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
C-C chemokine receptor type 5 Ligand Tak-220 Family 8 56
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 19 186
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Cruzipain Inhibitor 5-chloro-1-(4-chloro-benzyl)-1h-indole-2,3... 3 13
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Liver carboxylesterase 1 Inhibitor 7-chloro-1h-indole-2,3-dion... 6 5
Arachidonate 5-lipoxygenase Inhibitor Isaindigotone Family 1 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor Benz... 3 12
cAMP-specific 3',5'-cyclic phosphodiesterase 4B Inhibitor 3-(2... 2 2
Phospholipase D1 Inhibitor Halopemide Family 17 111
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Metabotropic glutamate receptor 5 Ligand N-(3-acetamidophenyl)... 4 20
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
MO15-related protein kinase Pfmrk Inhibitor 2-chloro-n-(o-toly... 6 28
D(2) dopamine receptor Ligand PD-168077 Family 6 5
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Vasopressin V2 receptor and Vasopressin V1a receptor ligand N-... 5 8
Vasopressin V1a receptor and Vasopressin V2 receptor ligand CH... 3 5
Rho-associated protein kinase 2 inhibitor N-(7-chloro-1-oxo-2H... 13 42
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEDE family 7 17
C-C chemokine receptor type 3 ligand 4-[(3-acetylphenyl)carbam... 3 4
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
C-C chemokine receptor type 3 ligand SureCN6703027 family 2 1
Vasopressin V2 receptor ligand [2-chloro-4-(prop-2-enylamino)p... 3 14
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 53
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Cellular tumor antigen p53 and Inositol monophosphatase 1 inhi... 1 12
Prelamin-A/C and Lysine-specific demethylase 4E inhibitor 4-(4... 2 3
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 8 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 24 11
Ghrelin/growth hormone secretagogue receptor ligand AGN-PC-00A... 7 27
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 2 4
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 8 1
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 6 9
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 2 2
C-C chemokine receptor type 3 and Sodium-dependent serotonin t... 12 2
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19
D(2) dopamine receptor and Potassium voltage-gated channel sub... 1 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 2
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 5 2
Phospholipase D1 and Phospholipase D2 inhibitor 4-bromo-N-[(2S... 1 2
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Histamine H3 receptor ligand AGN-PC-0CW63F family 1 1
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
Nociceptin receptor and Delta-type opioid receptor ligand spir... 25 9
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 4
Coagulation factor X inhibitor N-(4-chlorophenyl)-2-[[4-(2-oxo... 2 0
Substance-K receptor and Neuromedin-K receptor ligand SureCN78... 2 4
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 2
Melanin-concentrating hormone receptor 1 ligand SureCN13451707... 3 1
Beta-secretase 1 and Beta-secretase 2 inhibitor AC1N6ZLA family 1 0
Sodium-dependent noradrenaline transporter inhibitor AGN-PC-07... 1 1
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 4 0
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZK family 3 0
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Cannabinoid receptor 1 ligand SureCN14463736 family 2 0
C-C chemokine receptor type 5 ligand AC1MHP8Y family 1 0
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 0
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 4 6
C-C chemokine receptor type 2 ligand AGN-PC-00D2HV family 2 2
Aldose reductase inhibitor (4R)-6-fluoro-3-methylspiro[1H-quin... 4 16
Tubulin beta-2B chain and Similar to alpha-tubulin isoform 1 i... 1 0
Glutamate receptor ionotropic, kainate 1 and Glutamate recepto... 1 12
Putative NP ZINC40310029 Family 8 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00262652 CHEMBL138552 Bioactive SureCN9046728
CFAMM00262638 DNC007339 Investigative Drug KKHT-20718
CFAMM00262661 DNC007341 Investigative Drug KKHT-10618
CFAMM00262636 DNC007336 Investigative Drug KKHT-11018
CFAMM00262660 DNC007340 Investigative Drug KKHT-20918
CFAMM00262635 DNC007337 Investigative Drug KKHT-10318
CFAMM00262639 DNC007338 Investigative Drug KKHT-20818

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27276 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543