CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2243
Family Name Metabotropic glutamate receptor 5 Ligand 2-methyl-6-((3-methoxyphenyl)ethynyl)-pyridine Family
No. of Seeds 3 No. of Other Members 9
Family Centroid CFAMM00262844 Functional Category Investigative Drug
Superfamily Metabotropic glutamate receptor 5 Ligand 2-methyl-6-((3-methoxyphenyl)ethynyl)-pyridine Superfamily
Class Class 2311

Cousin Family NamesSeedsMembers
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Histamine H1 receptor Ligand Doxylamine Family 2 91
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
Cytochrome b Inhibitor 2-nonyl-4-hydroxyquinoline N-OXIDE Family 2 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
Metabotropic glutamate receptor 5 Ligand 2-(3-chlorobenzyloxy)... 2 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Metabotropic glutamate receptor 5 Ligand 3-hydroxy-5-(2-methyl... 2 1
Metabotropic glutamate receptor 5 Ligand (3-(2-methylquinolin-... 3 6
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Metabotropic glutamate receptor 5 Ligand 2-phenylethynyl-5,6,7... 1 4
Leukotriene B4 receptor 1 ligand SureCN8772238 family 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,... 4 9
Metabotropic glutamate receptor 5 ligand 3-fluoro-5-[2-[6-(hyd... 1 0
Corticotropin-releasing factor receptor 1 ligand 3-ethyl-1-(2-... 5 15
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Glucocorticoid receptor ligand SureCN3894124 family 3 0
Coagulation factor X and Cationic trypsin inhibitor 1qb6 family 4 15
2,4,6-trimethyl-2,3-dihydrofuro[3,2-c]quinoline NP ZINC0009476... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00262848 CHEMBL2089181 Bioactive 3-methoxy-5-[2-(6-methylpyridin-2-yl)ethynyl]benzonitrile
CFAMM00262847 CHEMBL2112677 Bioactive 2-methyl-6-[2-[3-(tritritiomethoxymethyl)phenyl]ethynyl]pyridine
CFAMM00262844 DNC007347 Investigative Drug 2-methyl-6-((3-methoxyphenyl)ethynyl)-pyridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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