CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2247
Family Name Gonadotropin-releasing hormone receptor Ligand [d-ncy(methyl)4]acyline Family
No. of Seeds 32 No. of Other Members 0
Family Centroid CFAMM00263019 Functional Category Investigative Drug
Superfamily Gonadotropin-releasing hormone Inhibitor ASP3550 Superfamily
Class Class 980

Cousin Family NamesSeedsMembers
Gonadotropin-releasing hormone receptor Ligand decapeptide ana... 9 162
HIV protease Inhibitor Indinavir Family 36 211
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
Growth hormone receptor Ligand EP-51216 Family 34 390
ABC294640 family 5 75
Gonadotropin-releasing hormone Inhibitor ASP3550 Family 33 60
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Gonadotropin-releasing hormone receptor Ligand Azaline B Family 12 0
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 46 0
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Pol polyprotein inhibitor penicillin deriv. 40 family 2 4
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Coagulation factor X and Prothrombin inhibitor SureCN8243313 f... 10 8
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
Gonadotropin-releasing hormone receptor ligand (3S)-3-[[(2S)-2... 5 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 4 1
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
KiSS-1 receptor ligand SureCN5132924 family 2 4
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 1 0
Mitogen-activated protein kinase 14 inhibitor SureCN14185127 f... 2 0


External ID

Functional Category

Molecule Name

CFAMM00263004 CHEMBL410799 Bioactive CHEMBL410799
CFAMM00262985 CHEMBL219562 Bioactive CHEMBL219562
CFAMM00263025 CHEMBL414558 Bioactive CHEMBL414558
CFAMM00262992 CHEMBL415351 Bioactive CHEMBL415351
CFAMM00263015 CHEMBL2370592 Bioactive CHEMBL2370592
CFAMM00262984 CHEMBL216519 Bioactive CHEMBL216519
CFAMM00263003 CHEMBL411144 Bioactive CHEMBL411144
CFAMM00262991 CHEMBL414061 Bioactive CHEMBL414061
CFAMM00263014 CHEMBL2370590 Bioactive CHEMBL2370590
CFAMM00262981 CHEMBL438018 Bioactive CHEMBL438018
CFAMM00263001 CHEMBL405736 Bioactive CHEMBL405736
CFAMM00262990 CHEMBL429016 Bioactive CHEMBL429016
CFAMM00263013 CHEMBL262180 Bioactive CHEMBL262180
CFAMM00262998 CHEMBL376466 Bioactive CHEMBL376466
CFAMM00262989 CHEMBL269711 Bioactive CHEMBL269711
CFAMM00263012 CHEMBL267642 Bioactive CHEMBL267642
CFAMM00263029 CHEMBL219799 Bioactive CHEMBL219799
CFAMM00262997 CHEMBL406337 Bioactive CHEMBL406337
CFAMM00262988 CHEMBL269097 Bioactive CHEMBL269097
CFAMM00263028 CHEMBL413752 Bioactive CHEMBL413752
CFAMM00262995 CHEMBL407615 Bioactive CHEMBL407615
CFAMM00263017 CHEMBL2370594 Bioactive CHEMBL2370594
CFAMM00262986 CHEMBL444903 Bioactive CHEMBL444903
CFAMM00263006 CHEMBL2370589 Bioactive CHEMBL2370589
CFAMM00263026 CHEMBL263691 Bioactive CHEMBL263691
CFAMM00262993 CHEMBL434380 Bioactive CHEMBL434380
CFAMM00263016 CHEMBL2370593 Bioactive CHEMBL2370593
CFAMM00263023 DNC007369 Investigative Drug [Ncy(methyl)4]acyline
CFAMM00263022 DNC007368 Investigative Drug [Ncy(SO,methyl)4]acyline
CFAMM00263019 DNC007367 Investigative Drug [D-Ncy(methyl)4]acyline
CFAMM00263018 DNC007366 Investigative Drug [D-Ncy(SO,methyl)4]acyline
CFAMM00263008 DNC007371 Investigative Drug [D-Ncy(2-naphthyl)1]acyline

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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