CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2273
Family Name Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrimidin-4-ylamino)benzoic Acid Family
No. of Seeds 12 No. of Other Members 30
Family Centroid CFAMM00264046 Functional Category Investigative Drug with Natural Product
Superfamily Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrimidin-4-ylamino)benzoic Acid Superfamily
Class Class 850

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Type-1 angiotensin II receptor Ligand Telmisartan Family 4 181
Type-1 angiotensin II receptor Ligand Eprosartan Family 36 176
Prostaglandin G/H synthase 2 Inhibitor Niflumic Acid Family 7 119
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Histamine H1 receptor Ligand Mepyramine Family 5 65
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Aurora kinase A Inhibitor MLN8054 Family 2 5
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Casein kinase II subunit alpha Inhibitor CX-4945 Family 1 7
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
MK-6096 family 3 69
Tyrosine-protein kinase BTK Inhibitor CC-292 Family 6 10
JAK Inhibitor Momelotinib Family 33 83
XL-888 family 16 85
Glucokinase Inhibitor GKA1 Family 2 67
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor 1-methyl-8-(... 1 1
Type-1 angiotensin II receptor ligand SureCN9527437 family 2 34
Adenosine receptor A1 ligand AGN-PC-07PMLW family 6 4
Dihydrofolate reductase and Thymidylate synthase inhibitor 2-[... 10 5
Dihydrofolate reductase inhibitor 2-[[4-carboxy-4-[[4-[(2,4-di... 3 1
Dihydrofolate reductase inhibitor AGN-PC-075RRH family 2 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Nuclear receptor ROR-gamma and Mitogen-activated protein kinas... 1 10
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 22
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Hepatocyte growth factor receptor and Insulin receptor ligand ... 4 15
Prostaglandin D2 receptor ligand 2-[3-[6-[2-(2,4-dichloropheny... 7 2
Dipeptidyl peptidase 4 inhibitor 3-[6-[(3R,4S)-3-amino-4-(2,4,... 3 7
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Mitogen-activated protein kinase 14 inhibitor SureCN3305171 fa... 1 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 7 1
Wee1-like protein kinase and ALK tyrosine kinase receptor liga... 1 9
Neuropeptide Y receptor type 5 ligand AGN-PC-07R6YQ family 7 7
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 3-methyl-4... 15 14
Lysine--tRNA ligase inhibitor 4-[[2-(2-piperazin-1-ylpyridin-4... 2 0
Type-1A angiotensin II receptor ligand 2-[[2-butyl-3-[(4-carbo... 2 4
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 2-[3-[... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Aurora kinase A inhibitor Bisanilinopyrimidine, 6i family 1 0
Aurora kinase A inhibitor Bisanilinopyrimidine, 6j family 2 1
Aurora kinase A inhibitor 4-[[4-(2-chloroanilino)pyrimidin-2-y... 1 0
Cathepsin K and Cathepsin L1 inhibitor 2-Cyano-pyrimidine, 17a... 5 8
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Tyrosine-protein kinase JAK2 inhibitor 4-[[8-(1-propan-2-ylpyr... 5 6
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
C-C chemokine receptor type 5 ligand 4-[[5-[[4-[(5R)-5-(3-chlo... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Ephrin type-A receptor 3 and Tyrosine-protein kinase Fgr ligan... 1 3
Macrophage colony-stimulating factor 1 receptor and Mast/stem ... 27 4
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 3 6
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 1 2
Peroxisome proliferator-activated receptor gamma and Cytochrom... 1 1
Vascular endothelial growth factor receptor 2 ligand pyrimidin... 2 2
Thromboxane-A synthase inhibitor AGN-PC-00NE8C family 2 3
Type-1 angiotensin II receptor ligand 2-ethyl-4-[[4-[2-(2H-tet... 2 0
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-071H3F fa... 3 0
Serine/threonine-protein kinase Sgk1 inhibitor SureCN3774571 f... 2 18
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 4
Adenosine receptor A2a and Adenosine receptor A1 ligand N-benz... 3 12
Diacylglycerol O-acyltransferase 1 inhibitor 2-[4-[4-(4-amino-... 2 3
Signal transducer and activator of transcription 6 inhibitor A... 4 0
Signal transducer and activator of transcription 6 inhibitor 2... 1 0
Cyclic AMP-dependent transcription factor ATF-1 and Nuclear fa... 3 0
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00264043 CHEMBL2170422 Bioactive Bisanilinopyrimidine, 3r
CFAMM00264046 DNC007455 Investigative Drug 2-(2-phenoxypyrimidin-4-ylamino)benzoic acid
CFAMM00264045 DNC007456 Investigative Drug 2-(2-sec-butoxypyrimidin-4-ylamino)benzoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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