CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2274
Family Name Platelet-derived growth factor receptor beta and Ephrin type-B receptor 4 Ligand TG-100435 Family
No. of Seeds 9 No. of Other Members 16
Family Centroid CFAMM00264075 Functional Category Investigative Drug
Superfamily Platelet-derived growth factor receptor beta and Ephrin type-B receptor 4 Ligand TG-100435 Superfamily
Class Class 2014

Cousin Family NamesSeedsMembers
Mitogen-activated protein kinase 12 Inhibitor Birb 796 Family 20 43
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 3 23
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 37
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Mitogen-activated protein kinase 14 inhibitor 1-[5-tert-butyl-... 1 4
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 31 11
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Neuropeptide Y receptor type 1 ligand 1-[3-[1-(cyclohexylmethy... 15 9
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 5
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 26 7
Voltage-dependent calcium channel subunit alpha-2/delta-1 and ... 9 15
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 2
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 3 1
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 1-... 8 6
Tyrosine-protein kinase ABL1 inhibitor AGN-PC-00AWSY family 13 3
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 12 2
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... 5 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 5 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 0
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN136... 1 0
Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... 4 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Oxytocin receptor ligand AGN-PC-07C71T family 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Glucokinase inhibitor AGN-PC-03ZE5E family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00264095 CHEMBL256101 Bioactive 7-(2,6-dichlorophenyl)-5-methyl-N-[4-[2-(1-oxidopyrrolidin-1-ium-1-yl)ethoxy]phenyl]-1,2,4-benzotriazin-3-amine
CFAMM00264087 CHEMBL400402 Bioactive TG 100572
CFAMM00264076 CHEMBL230829 Bioactive SureCN4271485
CFAMM00264093 CHEMBL218102 Bioactive AGN-PC-00EMNQ
CFAMM00264085 CHEMBL230830 Bioactive SureCN4268405
CFAMM00264079 CHEMBL218549 Bioactive AGN-PC-00BH3C
CFAMM00264096 CHEMBL218656 Bioactive AGN-PC-00E7RN
CFAMM00264075 DNC007460 Investigative Drug TG-100435

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27771 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543