CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2285
Family Name C-X-C chemokine receptor type 3 Ligand AMG-487 Family
No. of Seeds 28 No. of Other Members 73
Family Centroid CFAMM00264369 Functional Category Investigative Drug with Natural Product
Superfamily Smoothened homolog Inhibitor LDE225 Superfamily
Class Class 1163

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Smoothened homolog Inhibitor LDE225 Family 3 76
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
E7050 family 2 13
MK-6096 family 3 69
Glucokinase Inhibitor GKA1 Family 2 67
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Melanin-concentrating hormone receptor 1 Ligand Gnf-pf-2322 Fa... 3 95
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Hepatocyte growth factor receptor Ligand BMS-777607 Family 10 1
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
5-hydroxytryptamine receptor 2C Ligand 4-(piperazin-1-yl)furo[... 3 11
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand Divapl... 3 47
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
Reverse transcriptase/RNaseH inhibitor AC1LALKM family 2 19
Neutrophil elastase inhibitor phenyl N-[(2S)-1-[(2S)-2-[[(3S)-... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Gonadotropin-releasing hormone receptor ligand 1-[(2,6-difluor... 6 31
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Tyrosine-protein kinase ABL1 inhibitor AGN-PC-04S3QV family 1 2
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Somatostatin receptor type 5 ligand AGN-PC-088VSK family 2 3
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Reverse transcriptase/RNaseH inhibitor Dipyridodiazepinone der... 1 8
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Prothrombin inhibitor AGN-PC-09QMX4 family 1 4
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
Platelet-activating factor receptor ligand SureCN7497229 family 4 2
Cannabinoid receptor 1 ligand AGN-PC-03I5TW family 3 12
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
Vasopressin V1b receptor ligand AGN-PC-00HJ2S family 4 6
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Reverse transcriptase/RNaseH and Cytochrome P450 2C19 inhibito... 7 2
Corticotropin-releasing factor receptor 1 ligand AGN-PC-009TSL... 3 3
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 10 15
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 0
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 1 13
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
D(2) dopamine receptor and D(3) dopamine receptor ligand N-[3-... 7 3
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Glycogen synthase kinase-3 beta inhibitor CHEMBL1940907 family 2 21
Glycogen synthase kinase-3 beta inhibitor CHEMBL1940990 family 3 3
Glycogen synthase kinase-3 beta inhibitor CHEMBL1940986 family 1 0
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 1... 1 0
Melanin-concentrating hormone receptor 1 ligand N-[1-(1,3-benz... 2 5
Growth hormone secretagogue receptor type 1 and Potassium volt... 3 0
Growth hormone secretagogue receptor type 1 and Potassium volt... 3 1
Growth hormone secretagogue receptor type 1 and Potassium volt... 2 0
Growth hormone secretagogue receptor type 1 ligand 2-methyl-6-... 2 0
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 3 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Histamine H3 receptor ligand AGN-PC-075YXY family 1 4
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Protein kinase C theta type and Protein kinase C delta type in... 1 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 1 1
ALK tyrosine kinase receptor ligand 4-fluoro-N-[1-[4-(propan-2... 1 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 3 3
Cathepsin K and Cathepsin L1 inhibitor 2-Cyano-pyrimidine, 17a... 5 8
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 2 0
Motilin receptor ligand SureCN2768193 family 2 1
Motilin receptor ligand SureCN2765637 family 1 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
Metabotropic glutamate receptor 5 ligand AGN-PC-0DB8TJ family 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 5 4
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Bifunctional epoxide hydrolase 2 inhibitor 8-(1H-benzimidazole... 1 0
Bifunctional epoxide hydrolase 2 inhibitor 8-(5-methylpyrazine... 1 0
Metabotropic glutamate receptor 5 and Cytochrome P450 3A4 liga... 3 7
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 1
Gonadotropin-releasing hormone receptor ligand 2-tert-butyl-8-... 6 23
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Reverse transcriptase/RNaseH inhibitor PETT deriv. 14 family 1 0
Adenosine kinase inhibitor AGN-PC-0757MS family 2 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X2R ... 1 3
Tyrosine-protein kinase Lck inhibitor SureCN374434 family 1 1
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 5 0
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 2 2
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 6 1
Histamine H3 receptor ligand AGN-PC-03Z8HB family 3 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 0
Acyl-CoA desaturase inhibitor SureCN1182719 family 1 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 2 0
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[3-(4-cyanoph... 2 0
Tyrosine-protein kinase receptor Tie-1 and Receptor-type tyros... 1 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-07R5ZB family 4 3
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 2 25
Transient receptor potential cation channel subfamily V member... 1 3
Hydroxycarboxylic acid receptor 2 and Hydroxycarboxylic acid r... 2 3
Metabotropic glutamate receptor 5 ligand AGN-PC-09QJ1Q family 1 0
Hepatocyte growth factor receptor ligand [4-[6-amino-5-[1-(2,6... 5 1
Diacylglycerol O-acyltransferase 1 inhibitor 3-[[1-[5-[(3-meth... 1 1
Diacylglycerol O-acyltransferase 1 inhibitor 2-[[4-[5-[(3-meth... 2 6
Thromboxane-A synthase and Platelet-activating factor receptor... 1 6
Thromboxane-A synthase and Platelet-activating factor receptor... 1 0
Vascular endothelial growth factor receptor 2 ligand SureCN472... 1 0
5-(4-methoxyphenyl)-4-oxo-1H-pyrido[2,3-d]pyrimidin-2-olate NP... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00264334 CHEMBL193125 Bioactive 4-[2-(11-ethyl-5-methyl-6-oxodipyrido[2,3-d:2',3'-h][1,4]diazepin-8-yl)ethoxy]benzoic acid
CFAMM00264361 CHEMBL1077830 Bioactive SureCN1893453
CFAMM00264422 CHEMBL484611 Bioactive AGN-PC-00CMGY
CFAMM00264374 CHEMBL364043 Bioactive AC1MHVAJ
CFAMM00264387 CHEMBL1939697 Bioactive N-[(1R)-1-[3-(4-hydroxyphenyl)-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(pyridin-3-ylmethyl)-2-[4-(trifluoromethoxy)phenyl]acetamide
CFAMM00264327 CHEMBL1077816 Bioactive N-[(1R)-1-[3-(4-ethoxyphenyl)-4-oxoquinazolin-2-yl]ethyl]-N-(pyridin-3-ylmethyl)-2-(3,4,5-trifluorophenyl)acetamide
CFAMM00264340 CHEMBL404201 Bioactive N-[(1R)-1-[3-(4-ethoxyphenyl)-4-oxoquinazolin-2-yl]ethyl]-2-[4-fluoro-3-(trifluoromethyl)phenyl]-N-(pyridin-3-ylmethyl)acetamide
CFAMM00264354 CHEMBL1077824 Bioactive N-[(1R)-1-[3-(4-ethoxyphenyl)-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-2-[4-fluoro-3-(trifluoromethyl)phenyl]-N-[[(2R)-1-propan-2-ylpyrrolidin-2-yl]methyl]acetamide
CFAMM00264347 CHEMBL1077823 Bioactive N-[(1R)-1-[3-(4-ethoxyphenyl)-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-2-[4-fluoro-3-(trifluoromethyl)phenyl]-N-[(3-methyl-1,2-oxazol-5-yl)methyl]acetamide
CFAMM00264326 CHEMBL1077819 Bioactive N-[(1R)-1-[3-(4-ethoxyphenyl)-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-2-[4-fluoro-3-(trifluoromethyl)phenyl]-N-(pyridin-3-ylmethyl)acetamide
CFAMM00264353 CHEMBL1077825 Bioactive N-[(1R)-1-[3-(4-ethoxyphenyl)-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-2-[4-fluoro-3-(trifluoromethyl)phenyl]-N-[[(2S)-1-propan-2-ylpyrrolidin-2-yl]methyl]acetamide
CFAMM00264338 CHEMBL1097142 Bioactive 3l8v
CFAMM00264352 CHEMBL1077826 Bioactive N-[(1R)-1-[3-(4-ethoxyphenyl)-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-2-[4-fluoro-3-(trifluoromethyl)phenyl]-N-[[(2R)-pyrrolidin-2-yl]methyl]acetamide
CFAMM00264325 CHEMBL1077818 Bioactive N-[(1R)-1-[3-(4-ethoxyphenyl)-4-oxoquinazolin-2-yl]ethyl]-2-[3-fluoro-4-(trifluoromethoxy)phenyl]-N-(pyridin-3-ylmethyl)acetamide
CFAMM00264419 CHEMBL1077809 Bioactive N-[(1R)-1-[3-(4-ethoxyphenyl)-4-oxoquinazolin-2-yl]ethyl]-N-(pyridin-3-ylmethyl)-2-[4-(trifluoromethyl)imidazol-1-yl]acetamide
CFAMM00264410 CHEMBL1077828 Bioactive SureCN4812931
CFAMM00264425 CHEMBL436826 Bioactive SureCN5838280
CFAMM00264351 CHEMBL1077827 Bioactive N-[(1R)-1-[3-(4-ethoxyphenyl)-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-2-[4-fluoro-3-(trifluoromethyl)phenyl]-N-[(1-methylpiperidin-4-yl)methyl]acetamide
CFAMM00264403 CHEMBL1075640 Bioactive N-[(1R)-1-[3-(4-ethoxyphenyl)-4-oxoquinazolin-2-yl]ethyl]-2-[3-fluoro-4-(trifluoromethyl)phenyl]-N-(pyridin-3-ylmethyl)acetamide
CFAMM00264336 CHEMBL230664 Bioactive N-[(1R)-1-[3-(4-ethoxyphenyl)-4-oxoquinazolin-2-yl]ethyl]-N-(pyridin-3-ylmethyl)-2-[4-(trifluoromethoxy)phenyl]acetamide
CFAMM00264363 CHEMBL1077832 Bioactive SureCN12857869
CFAMM00264382 CHEMBL385178 Bioactive N-(4-Phenoxyphenyl)-2-[(Pyridin-4-Ylmethyl)amino]nicotinamide
CFAMM00264408 CHEMBL1077829 Bioactive N-[(1R)-1-[3-(4-ethoxyphenyl)-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-2-[4-fluoro-3-(trifluoromethyl)phenyl]-N-(oxan-4-yl)acetamide
CFAMM00264362 CHEMBL1077831 Bioactive N-(2-ethylsulfonylethyl)-2-[4-fluoro-3-(trifluoromethyl)phenyl]-N-[(1R)-1-[4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]pyrido[2,3-d]pyrimidin-2-yl]ethyl]acetamide
CFAMM00264328 CHEMBL1077817 Bioactive 2-[3,5-bis(trifluoromethyl)phenyl]-N-[(1R)-1-[3-(4-ethoxyphenyl)-4-oxoquinazolin-2-yl]ethyl]-N-(pyridin-3-ylmethyl)acetamide
CFAMM00264401 CHEMBL1081164 Bioactive N-(1-acetylpiperidin-4-yl)-N-[(1R)-1-[3-(4-ethoxyphenyl)-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-2-[4-fluoro-3-(trifluoromethyl)phenyl]acetamide
CFAMM00264369 DNC007517 Investigative Drug AMG-487

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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