CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2287
Family Name TGF-beta receptor type-1 Ligand SB-431542 Family
No. of Seeds 2 No. of Other Members 42
Family Centroid CFAMM00264531 Functional Category Investigative Drug with Natural Product
Superfamily TGF-beta receptor type-1 and Telomerase reverse transcriptase Binder Superfamily
Class Class 1456

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Tyrosine kinase Inhibitor PKI166 Family 17 198
5-hydroxytryptamine receptor 3A and Alpha-2A adrenergic recept... 31 24
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
Peptide deformylase, mitochondrial Inhibitor 8-(2,3,4-trimetho... 8 15
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Serine/threonine-protein kinase Chk2 Inhibitor 5-nitro-2-(4-ph... 6 3
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 3 23
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Leukotriene B4 receptor 1 Ligand Leucettamine A Family 2 0
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Reverse transcriptase Inhibitor Atevirdine Family 4 55
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Integrin beta-3 and Integrin alpha-V inhibitor 2-[(2S)-7-[1H-b... 3 6
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 7
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 10
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 5 45
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Dual specificity protein kinase CLK1 and Dual specificity prot... 2 14
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
Neuropeptide Y receptor type 5 ligand 3-[2-[6-[2-[(2-methylpro... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 4
Dihydrofolate reductase inhibitor 7-(3,4-dimethoxyphenyl)-6-me... 1 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 5 20
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
Smoothened homolog inhibitor N-[3-(1H-benzimidazol-2-yl)phenyl... 2 1
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Nitric oxide synthase, inducible inhibitor SureCN5194847 family 24 48
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 11 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Glycogen synthase kinase-3 beta inhibitor 3-imidazo[1,2-a]pyri... 1 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(1H-benzimidazole... 1 0
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-amin... 4 3
Adenosine receptor A1 and Adenosine receptor A2a ligand N-[4-(... 4 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X2R ... 1 3
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Histidinol dehydrogenase inhibitor (3S)-3-amino-1-(1,3-benzodi... 1 0
Neuropeptide Y receptor type 5 ligand 1'-(5H-[1,3]dioxolo[4,5-... 2 1
Adenosine receptor A1 ligand BAS 00727702 family 1 4
D(2) dopamine receptor ligand AGN-PC-07C1V6 family 2 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 4
Dihydrofolate reductase inhibitor AGN-PC-073PP8 family 1 0
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[2-(1H-benzimidaz... 3 2
TGF-beta receptor type-1 ligand AGN-PC-07CRDB family 5 4
DNA-(apurinic or apyrimidinic site) lyase and Survival motor n... 1 2
Bombesin receptor subtype-3 ligand AGN-PC-077RXY family 2 1
Putative NP ZINC32497112 Family 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00264531 DNC007530 Investigative Drug SB-431542
CFAMM00264526 DNC010928 Investigative Drug SB-505124

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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