CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2300
Family Name Acetylcholinesterase Inhibitor AP-2238 Family
No. of Seeds 2 No. of Other Members 109
Family Centroid CFAMM00264816 Functional Category Investigative Drug with Natural Product
Superfamily Muscarinic acetylcholine receptor Ligand Mebeverine Superfamily
Class Class 333

Cousin Family NamesSeedsMembers
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Kappa-type opioid receptor Ligand Fedotozine Family 1 11
Endothelin-1 receptor Ligand PD156707 Family 41 211
Arachidonate 15-lipoxygenase Inhibitor Isoscopoletin Family 5 98
Platelet-activating factor receptor Ligand L-652731 Family 5 116
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Acetylcholinesterase Inhibitor Taspine Family 1 0
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Androgen receptor Ligand Palodesangren E Family 12 43
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 27
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 4 10
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-ben... 5 334
Endothelin-1 receptor ligand (2S)-2-(1,3-benzodioxol-5-yl)-4-m... 17 0
Muscarinic acetylcholine receptor M5 and Muscarinic acetylchol... 1 3
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-[(4... 3 53
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-ben... 3 2
Acetylcholinesterase and Butyrylcholinesterase inhibitor 6,7-d... 1 29
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 7
Putative NP ZINC20762875 Family 7 1
Putative NP ZINC04060846 Family 1 0
8,10-dihydropyrano[2,3-f][1,3]benzoxazin-2-one NP 3-(furan-2-y... 6 1
NP ((1r,4as,8as)-4a-hydroxy-1-(3,4,5-trimethoxyphenyl)octahydr... 3 3
NP 3-(benzo[d][1,3]dioxol-5-ylmethyl)-3,4-dihydrobenzo[3,4]chr... 3 0


External ID

Functional Category

Molecule Name

CFAMM00264816 DNC007569 Investigative Drug AP-2238
CFAMM00264800 DNC007570 Investigative Drug AP-2243

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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