CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2303
Family Name Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinolin-4(5h)-one Family
No. of Seeds 3 No. of Other Members 11
Family Centroid CFAMM00264849 Functional Category Investigative Drug
Superfamily Poly [ADP-ribose] polymerase 1 and Serine/threonine-protein kinase Chk1 Binder Superfamily
Class Class 1032

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Cyclin-dependent kinase 2 Inhibitor AT7519 Family 2 14
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Neuromedin-K receptor Ligand SB222200 Family 17 235
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
Hepatocyte growth factor receptor Ligand MK-8033 Family 19 42
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Growth hormone receptor Ligand EP-51216 Family 34 390
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
HIV protease Inhibitor BIT225 Family 2 2
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-chlorophenyl)-5-... 2 8
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 4
Cyclin-dependent kinase 1 and G2/mitotic-specific cyclin-B1 In... 2 0
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 5 10
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
Neutrophil elastase Inhibitor (4-bromo-1h-pyrazol-1-yl)(o-toly... 5 4
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 19 12
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Adenosine receptor A3 Ligand 2-phenyl-2h-pyrazolo[4,3-d]pyrimi... 2 7
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Poly [ADP-ribose] polymerase 1 Inhibitor 2-phenylpyrazolo-[1,5... 1 1
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand Ripaze... 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Histone deacetylase Inhibitor ST-5732 Family 8 6
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... 2 4
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Orexin receptor type 2 and Orexin receptor type 1 ligand AGN-P... 7 19
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 2 1
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Glycogen synthase kinase-3 beta inhibitor AGN-PC-07ZA4D family 1 0
Mitogen-activated protein kinase 14 and Mast/stem cell growth ... 4 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 11
5-hydroxytryptamine receptor 2A ligand AGN-PC-04RTMN family 7 5
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 21
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
Serine/threonine-protein kinase D3 and Protein kinase C delta ... 3 0
5-hydroxytryptamine receptor 3A ligand SureCN8035577 family 5 4
Metabotropic glutamate receptor 1 ligand GTPL6334 family 6 4
Glycogen synthase kinase-3 beta and Tyrosine-protein kinase JA... 1 0
Glucocorticoid receptor ligand N-ethyl-2-fluoro-N-[3,3,3-trifl... 16 7
Serine/threonine-protein kinase 17A and Myosin light chain kin... 3 7
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
Hepatocyte growth factor receptor ligand 9-[[3-methoxypropyl(m... 17 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 3 5
Protein kinase C beta type and Protein kinase C delta type inh... 1 2
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 1 0
Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazo... 10 0
Glycogen synthase kinase-3 beta inhibitor 3-(2-bromoacetyl)-4-... 1 0
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 0
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Histamine H3 receptor ligand N-methyl-N-[(3R)-1-propan-2-ylpyr... 3 1
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 18
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 2 2
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 3 6
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
5-hydroxytryptamine receptor 3A ligand N-[(1S,5S)-9-methyl-9-a... 1 0
5-hydroxytryptamine receptor 3A ligand 1-[3-[[5-(dimethylamino... 1 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
cAMP-dependent protein kinase catalytic subunit PRKX and Rho-a... 1 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Calcitonin gene-related peptide type 1 receptor ligand 3-[1-[4... 5 3
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 5 3
Hepatocyte growth factor receptor ligand 5-(3-methyl-1,2-thiaz... 5 2
5-hydroxytryptamine receptor 4 ligand N-[(1R,5S)-8-[2-hydroxy-... 4 0
Coagulation factor X inhibitor AGN-PC-02WFR7 family 7 13
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 2 1
5-hydroxytryptamine receptor 3A ligand 5-hydroxy-1-methyl-N-[(... 4 2
5-hydroxytryptamine receptor 4 ligand 4-[2-[4-[[(1-propan-2-yl... 1 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Cathepsin S inhibitor 4-acetamido-N-[(S)-[1-(1-cyanocyclopropy... 4 0
Coagulation factor X and Prothrombin inhibitor SureCN5819494 f... 5 8
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand N-(oxan-... 2 0
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Fatty-acid amide hydrolase 1 inhibitor 1-[3-[4-(6-phenylhexyl)... 1 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 3
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 1
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 1 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Metabotropic glutamate receptor 5 ligand 5-(4-chlorophenyl)-1,... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Neutrophil elastase and Chymotrypsinogen B inhibitor 1-(3-meth... 1 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 4 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 6-(b... 5 5
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 1
Cannabinoid receptor 1 ligand AGN-PC-07R6QU family 4 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
D(4) dopamine receptor and D(1A) dopamine receptor ligand 3-[[... 1 0
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 0
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 0
Rho-associated protein kinase 1 and Ribosomal protein S6 kinas... 4 2
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Cathepsin L1 and Cathepsin L2 inhibitor 5-tert-butyl-N-[(2S)-1... 2 5
D(3) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 2 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand (2... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R6UP family 2 0
TGF-beta receptor type-1 ligand N-(3-cyanophenyl)-2-[3-(6-meth... 4 5
Tyrosine-protein kinase receptor TYRO3 ligand 3-amino-6-(1H-in... 2 3
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 4 0
Cyclin-dependent kinase 2 inhibitor N-[(4-chlorophenyl)carbamo... 7 2
Apoptosis regulator Bcl-2 and Bcl2-associated agonist of cell ... 3 3
TGF-beta receptor type-1 ligand SureCN373106 family 4 1
Nuclear receptor ROR-gamma and Ras-related protein Rab-9A liga... 1 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00264850 DNC007579 Investigative Drug 2-m-tolyl-2H-pyrazolo[3,4-c]quinolin-4(5H)-one
CFAMM00264847 DNC007641 Investigative Drug 1-benzoyl-N-phenyl-1H-pyrazole-3-carboxamide
CFAMM00264849 DNC007576 Investigative Drug 2-benzyl-2H-pyrazolo[3,4-c]quinolin-4(5H)-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

23111 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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