CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2311
Family Name Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4-biphenylyl]urea Family
No. of Seeds 7 No. of Other Members 134
Family Centroid CFAMM00264927 Functional Category Investigative Drug with Natural Product
Superfamily Kinesin-like protein KIF11 Binder Superfamily
Class Class 2421

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand iminostilbene derivative (tricyclic stru... 2 46
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Histone deacetylase 1 Inhibitor Vorinostat Family 26 138
Motilin receptor Ligand GSK962040 Family 30 457
Pan-DAC Inhibitor AR-42 Family 21 153
NMDA receptor Ligand Aptiganel Hcl Family 2 82
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Urokinase-type plasminogen activator Inhibitor N-(1-adamantyl)... 2 15
Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phen... 5 65
5-hydroxytryptamine receptor 5A Ligand N,4-dimethyl-3,4-dihydr... 8 51
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 14 78
Progesterone receptor Ligand 2,2,4-trimethyl-6-phenyl-1,2-dihy... 5 82
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-chloro-phenyl)... 5 50
Transient receptor potential cation channel subfamily V member... 6 33
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-[2-(... 5 72
Transient receptor potential cation channel subfamily V member... 4 38
Androgen receptor Ligand YM-175735 Family 30 129
Cannabinoid receptor 1 Ligand 1-(bis(4-chlorophenyl)methyl)-3-... 4 44
Kinesin-like protein KIF11 Inhibitor N-{4'-[(trifluoromethyl)s... 3 1
Kinesin-like protein KIF11 Inhibitor N-(4'-bromo-3,3'-difluoro... 2 0
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 2 9
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 13
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 1 16
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
Fatty-acid amide hydrolase 1 Inhibitor 1-biphenyl-4-ylmaleimid... 2 11
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 42
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 18
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 4 24
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 2
Tyrosinase Inhibitor 1-hydroxy-3-(4-(trifluoromethyl)phenyl)ur... 2 3
Trypsin Inhibitor 1,3-di-p-tolyl-[1,3]diazetidine-2,4-dione Fa... 2 16
DNA topoisomerase Inhibitor 6-p-tolylamino-1h-pyrimidine-2,4-d... 3 17
DNA topoisomerase Inhibitor 6-(indan-5-ylamino)-1h-pyrimidine-... 2 0
DNA topoisomerase Inhibitor 6-(naphthalen-2-ylamino)-1h-pyrimi... 2 1
DNA topoisomerase Inhibitor 6-(3-iodo-phenylamino)-1h-pyrimidi... 2 5
Growth hormone secretagogue receptor type 1 ligand AGN-PC-07ZB... 2 2
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 5 5
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04TGG7 family 2 3
Inosine-5'-monophosphate dehydrogenase inhibitor 1-[2-[3-[(E)-... 3 6
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 1-(2-c... 1 1
Melanin-concentrating hormone receptor 1 ligand 1-[2-[4-(3-cya... 3 2
Bifunctional epoxide hydrolase 2 inhibitor 1-(2,3,4-trifluorop... 2 2
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 2 6
Transient receptor potential cation channel subfamily V member... 9 38
Inosine-5'-monophosphate dehydrogenase inhibitor 1-[4-chloro-3... 3 5
Inosine-5'-monophosphate dehydrogenase inhibitor 1-(3,4-dichlo... 1 1
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor 1-(3,5... 2 0
C-C chemokine receptor type 3 ligand AGN-PC-073RIP family 2 4
C-C chemokine receptor type 5 ligand AC1L9YPM family 3 6
Transient receptor potential cation channel subfamily V member... 1 1
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRYI family 2 0
Melanin-concentrating hormone receptor 1 and Alpha-1A adrenerg... 1 0
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 2 2
Sterol O-acyltransferase 1 inhibitor SureCN7565101 family 2 10
Reverse transcriptase/RNaseH inhibitor (4S)-5-chloro-4-(2-cycl... 5 7
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN9352718 f... 2 3
Reverse transcriptase/RNaseH inhibitor (4S)-6-fluoro-4-(3-meth... 7 1
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN13328411 ... 4 2
Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2,6-di(propa... 7 2
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN9614694 f... 3 14
Acyl-CoA:cholesterol acyltransferase inhibitor AGN-PC-00F87B f... 3 1
Acyl-CoA:cholesterol acyltransferase inhibitor tetradecan-2-yl... 2 4
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 3
Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2,6-di(propa... 2 0
Extracellular calcium-sensing receptor ligand 478963-46-1 family 2 2
Acyl-CoA:cholesterol acyltransferase inhibitor N-[2,6-di(propa... 1 2
Androgen receptor ligand 1-[4-[3-[4-[(3,3-dimethyl-2-oxobutyl)... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00265009 CHEMBL90110 Bioactive SureCN9559085
CFAMM00264962 CHEMBL88148 Bioactive AGN-PC-074ND4
CFAMM00265015 CHEMBL243668 Bioactive AGN-PC-00EKHS
CFAMM00264985 DNC007599 Investigative Drug N-(4'-t-butyl-4-biphenylyl)urea
CFAMM00264950 DNC007600 Investigative Drug N-(4'-isopropyl-4-biphenylyl)urea
CFAMM00264949 DNC007602 Investigative Drug N-[3'-(trifluoromethyl)-4-biphenylyl]urea
CFAMM00264927 DNC007608 Investigative Drug N-[4'-(trifluoromethyl)-4-biphenylyl]urea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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