CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2324
Family Name Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimethoxybenzamide Family
No. of Seeds 3 No. of Other Members 30
Family Centroid CFAMM00265349 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Neutrophil elastase and D(2) dopamine receptor Binder Superfamily
Class Class 1766

Cousin Family NamesSeedsMembers
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Multidrug resistance protein Inhibitor Benzquinamide Family 1 41
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Zucapsacin family 7 177
Leukotriene B4 receptor 1 Ligand Ltb 019 Family 3 35
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Myeloperoxidase Inhibitor AZD5904 Family 1 2
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 6 40
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Kappa-type opioid receptor Ligand Fedotozine Family 1 11
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Poly [ADP-ribose] polymerase 1 Inhibitor 3-methoxybenzamide Fa... 2 23
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 16
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 4-hy... 2 13
Histamine H3 receptor Ligand A-349821 Family 49 228
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Histamine H1 receptor Ligand MDL-105212 Family 16 56
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Inhibitor 3... 1 8
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Intercellular adhesion molecule 1 Inhibitor Dehydropipernonali... 5 36
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Fatty-acid amide hydrolase 1 Inhibitor 4-(cyclohexylmethylcarb... 2 4
DNA topoisomerase 1 Inhibitor NSC-341622 Family 1 1
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Arachidonate 5-lipoxygenase Inhibitor 2-(4-butoxy-phenyl)-n-hy... 3 9
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Tyrosinase Inhibitor N-(2,4-dihydroxybenzyl)-3,4-dihydroxybenz... 3 2
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor 2-[3-[(1R... 9 46
Disintegrin and metalloproteinase domain-containing protein 17... 28 10
Pyruvate kinase PKM and Pyruvate kinase PKLR inhibitor MLS0022... 1 0
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Histamine H3 receptor ligand 1-(3,4-dimethoxyphenyl)-4-(4-pent... 2 0
Transient receptor potential cation channel subfamily V member... 3 18
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Substance-P receptor ligand AGN-PC-075NSQ family 9 3
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL15810... 1 1
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1589265 family 1 0
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Mu-type opioid receptor ligand AGN-PC-075GAW family 2 1
Collagenase 3 and 72 kDa type IV collagenase inhibitor N-[(3,4... 1 6
Melanin-concentrating hormone receptor 1 and Potassium voltage... 3 6
Histamine H3 receptor ligand 4-[[2-[2-[(2R)-2-methylpyrrolidin... 1 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
Sodium-dependent noradrenaline transporter and Sodium-dependen... 6 6
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 12 3
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Cannabinoid receptor 1 ligand AGN-PC-03RV6L family 10 3
Pol polyprotein inhibitor AC1LA3AI family 5 9
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
Cathepsin K inhibitor (2S)-2-[[2-(3,4-dimethoxyphenyl)acetyl]a... 1 1
Potassium voltage-gated channel subfamily H member 2 ligand 1-... 2 1
Enoyl-[acyl-carrier-protein] reductase [NADPH] inhibitor 4-(4-... 1 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 2-ben... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-[(4... 1 0
Prostaglandin D2 receptor ligand (E)-7-[(1S,3S,4R,5R)-4-(1,3-b... 1 0
NP ((1r,4as,8as)-4a-hydroxy-1-(3,4,5-trimethoxyphenyl)octahydr... 3 3
6,7-dihydropyrimido[6,1-a]isoquinolin-4-one NP ZINC02112138 Fa... 10 0
NP (7,8-dimethoxy-3-methyl-2,3-dihydro-1h-benzo[d]azepin-4-yl)... 4 2
Putative NP ZINC00519603 Family 8 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00265364 CHEMBL1229908 Bioactive ETHAMIVAN
CFAMM00265350 CHEMBL2013231 Bioactive N-[(E)-3-(2-fluorophenyl)-2-methylprop-2-enyl]-3,4-dimethoxy-N-[2-(1-methylpyrrolidin-2-yl)ethyl]benzamide
CFAMM00265349 DNC007637 Investigative Drug N,N-bis(cyanomethyl)-3,4-dimethoxybenzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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