CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2335
Family Name Delta-type opioid receptor and Kappa-type opioid receptor Ligand 1-benzhydryl-4-cyclohexylpiperidin-4-ol Family
No. of Seeds 7 No. of Other Members 19
Family Centroid CFAMM00265818 Functional Category Investigative Drug with Natural Product
Superfamily Adenosine receptor A3 and D(2) dopamine receptor Binder Superfamily
Class Class 2035

Cousin Family NamesSeedsMembers
Opioid receptor ligand synthetic opioid methadone analog Dextr... 2 108
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Histamine H1 receptor Ligand Terfenadine Family 3 50
5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Alpha adrenergic receptor Ligand Pseudoephedrine Family 4 96
Opioid receptor ligand opiate Levorphanol Family 18 537
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Alpha-1B adrenergic receptor ligand Morpholine derivative Phen... 4 152
Squalene monooxygenase Inhibitor Naftifine Family 8 32
Muscarinic acetylcholine receptor M1 Ligand Trihexyphenidyl Fa... 14 199
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
Histamine H1 receptor Ligand Chlophedianol Family 4 46
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45
Mu-type opioid receptor ligand opiate Methadyl Acetate Family 5 9
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Nicotinic acetylcholine receptor Ligand Benztropine Mesylate F... 10 20
Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family 2 4
Eptazocine Hbr family 6 8
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Pitolisant family 4 24
Zicronapine family 43 62
Muscarinic acetylcholine receptor Ligand Umeclidinium Family 7 50
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Sigma non-opioid intracellular receptor 1 Ligand Dimemorfan Fa... 5 15
Peptide deformylase, mitochondrial Inhibitor Hydroxamates Family 6 17
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Sulfen... 5 13
D(2) dopamine receptor and D(3) dopamine receptor Ligand (-)-3... 15 19
Adenosine receptor A3 and D(2) dopamine receptor Ligand (+)-bu... 5 14
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30
Cytochrome P450 2D6 Inhibitor Bs 7840 Family 4 9
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 10
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 3 1
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 3
Histamine H3 receptor Ligand 1-[2-(2,4,6-trimethyl-phenyl)-eth... 9 15
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Potassium voltage-gated channel subfamily H member 2 Ligand [1... 2 23
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 9 7
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-ri... 5 12
Sodium-dependent dopamine transporter and Sodium-dependent ser... 8 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 5 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 4 19
Sigma non-opioid intracellular receptor 1 ligand CHEMBL101300 ... 2 1
C-C chemokine receptor type 5 ligand AC1L9U82 family 2 3
Melanocortin receptor 4 and Melanocortin receptor 3 ligand Sur... 6 53
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 11
Sigma non-opioid intracellular receptor 1 ligand (1R)-1'-benzy... 7 27
Sigma non-opioid intracellular receptor 1 ligand 2-[(3R)-1'-(c... 2 0
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Vesicular acetylcholine transporter inhibitor BENZOVESAMICOL f... 7 4
Histamine H3 receptor ligand SureCN5551955 family 2 0
Vesicular acetylcholine transporter inhibitor (3R,4R)-1-[(3-io... 17 20
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 1 1
Transporter and Sodium-dependent serotonin transporter inhibit... 4 8
Histamine H3 receptor ligand 1-[[4-[4-[(1R)-4-methoxy-1-[(2S)-... 2 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 6 3
Sodium-dependent dopamine transporter and Transporter inhibito... 2 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 1 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 7
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 3 12
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 3 0
Vesicular acetylcholine transporter inhibitor (1R,2R)-2-spiro[... 3 2
Vesicular acetylcholine transporter inhibitor (4aR,6R,7R,8aR)-... 4 0
Squalene synthase inhibitor 3-[2-(4-phenylphenyl)ethynyl]-1-az... 2 1
Pol polyprotein inhibitor AC1LAH82 family 2 1
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-0793IB... 2 0
Sigma non-opioid intracellular receptor 1 ligand [(2R)-1,4-dib... 1 4
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 7
D(1A) dopamine receptor and D(3) dopamine receptor ligand (2S,... 5 5
Membrane primary amine oxidase and Amine oxidase [flavin-conta... 2 0
Voltage-dependent N-type calcium channel subunit alpha-1B and ... 1 3
Putative NP ZINC55525127 Family 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00265822 DNC007719 Investigative Drug 1-benzhydryl-4-cyclopropylpiperidin-4-ol
CFAMM00265821 DNC007712 Investigative Drug 1-benzhydryl-4-(3-phenylpropyl)piperidin-4-ol
CFAMM00265820 DNC007713 Investigative Drug 1-benzhydryl-4-benzylpiperidin-4-ol
CFAMM00265819 DNC007716 Investigative Drug 1-benzhydryl-4-tert-butylpiperidin-4-ol
CFAMM00265818 DNC007714 Investigative Drug 1-benzhydryl-4-cyclohexylpiperidin-4-ol
CFAMM00265817 DNC007715 Investigative Drug 1-benzhydryl-4-hexylpiperidin-4-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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