CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID234
Family Name Integrin alpha-V and Integrin beta-3 Inhibitor C[rgd-(s)-alpha-tfmfv] Family
No. of Seeds 19 No. of Other Members 95
Family Centroid CFAMM00184788 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Integrin alpha-V and Integrin beta-3 Binder Superfamily
Class Class 260

Cousin Family NamesSeedsMembers
Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Oxytocin receptor Ligand Oxytocin Family 30 182
Penicillin binding protein inhibitor β-lactam aminopenicillin ... 12 359
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
Prothrombin Inhibitor Ximelagatran Family 5 48
Atrial natriuretic peptide receptor 1 Ligand Nesiritide Family 6 111
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
Thymopentin family 20 133
Angiotensin-converting enzyme and Neprilysin Inhibitor M100,24... 18 60
Thymosin Beta-4 family 8 30
Maraciclatide family 2 0
Neuropeptide Y receptor type 1 Ligand BIBO3304 Family 4 69
Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
B1 bradykinin receptor Ligand B-9858 Family 4 14
Renin Inhibitor CP-80794 Family 16 112
Prothrombin Inhibitor Efegatran Family 9 47
Neprilysin Inhibitor Thiorphan Family 41 68
Prothrombin Inhibitor Ppack Family 5 4
Neuromedin-K receptor Ligand Senktide Family 15 22
Prothrombin Inhibitor D-leucyl-n-(4-carbamimidoylbenzyl)-l-pro... 13 44
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Integrin alpha-V and Integrin beta-3 Inhibitor Cyclo-[-arg-gly... 5 38
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Disintegrin and metalloproteinase domain-containing protein 17... 8 7
Integrin beta-3 Inhibitor Sibrafiban Family 4 6
Integrin beta-3 Inhibitor DMP-728 Family 3 0
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Integrin beta-3 Inhibitor SKF-107260 Family 5 8
Nociceptin receptor Ligand Fggftgcrkscrk Family 10 0
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Calcitonin gene-related peptide type 1 receptor Ligand Fvptdvg... 8 8
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Mu-type opioid receptor and Nociceptin receptor Ligand Ac-ryyr... 60 11
Beta-secretase 1 Inhibitor KMI-172 Family 3 0
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Chymase Inhibitor Chymostatin Family 2 3
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Disks large homolog 4 Inhibitor N-(3,4-difluorophenyl)propyl-e... 3 0
Substance-P receptor Ligand [sar9,met(o2)11]-sp Family 34 9
Integrin alpha-V Inhibitor C[rgdf-(3s)-carboxymorpholine] Family 10 2
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Receptor-type tyrosine-protein phosphatase C Ligand Asp-brpmp-... 2 0
Endothelin-converting enzyme 1 Inhibitor PO3 2-leu-nal-o-3k Fa... 3 26
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Genome polyprotein Inhibitor Acasp-glu-dif-glu-cha-cys Family 13 17
Genome polyprotein Inhibitor Acasp-glu-met-glu-cha-cys Family 3 6
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Serine/threonine protein phosphatase PP1-alpha 1 catalytic sub... 10 0
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 3 10
Trypsin Inhibitor P1 Argininal Derivative Family 13 36
Renin inhibitor (2S,4S,5S)-N-butyl-6-cyclohexyl-4-hydroxy-5-[[... 12 1
Tryptase alpha/beta-1 and Tryptase delta inhibitor (2S,3R)-3-[... 13 17
Tryptase alpha/beta-1 and Tryptase delta inhibitor (2S,3R)-1-b... 3 4
NS3 and Non-structural protein 4A inhibitor (4S)-4-[[(2S)-3-ca... 1 1
Caspase-1 inhibitor (3S)-3-[[(2S)-4-(2-naphthalen-1-ylethylami... 1 0
Prothrombin inhibitor SureCN7341151 family 6 7
Neprilysin inhibitor SureCN489232 family 3 9
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-5-phenyl... 4 1
Integrin beta-3 and Integrin alpha-IIb inhibitor (3S)-6-[[2-(4... 2 11
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7301018... 4 3
Growth factor receptor-bound protein 2 ligand 2-[(9S,10S,11E,1... 5 14
Endothelin-converting enzyme 1 and Cathepsin D inhibitor N-[(2... 6 2
Integrin beta-3 and Integrin alpha-V inhibitor 2-[(1R,5S,11S,1... 8 2
Menin inhibitor CHEMBL2314816 family 2 6
Integrin alpha-V and Integrin beta-5 inhibitor 2-[(2S,5R,8S,11... 2 1
Renin inhibitor 2-hydroxy-3-[[(4S,7S)-5-hydroxy-2,8-dimethyl-7... 1 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2S,4R)... 5 8
Cationic trypsin and Prothrombin inhibitor (3S,6S)-6-amino-6-b... 4 2
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R,6S,12S)-6... 7 0
Pol polyprotein inhibitor Diol-Based HIV-1 protease inhibitor ... 1 0
Pepsin A and Renin inhibitor N-[(3R)-1-[[(1S)-1-hydroxy-3-[[(2... 1 0
Chymase and Chymotrypsinogen B inhibitor AGN-PC-075LTI family 2 3
Histone deacetylase 1 and Histone deacetylase 8 inhibitor meth... 1 3
72 kDa type IV collagenase and Stromelysin-1 inhibitor (3R)-3-... 3 2
Angiotensin-converting enzyme inhibitor SureCN7263641 family 2 11
Growth hormone-releasing hormone receptor ligand (1S)-1'-[(2R)... 7 4
Ribonucleoside-diphosphate reductase large subunit and Ribonuc... 1 0
Neurotensin receptor type 2 and Neurotensin receptor type 1 li... 1 1
NS3 inhibitor 6-[[(2S)-1-[[(2S)-1-[(2S)-2-[[1-(cyclopropylamin... 2 0
Genome polyprotein inhibitor Benzoyl-KKR-H family 1 1
Bcl-2-like protein 1 inhibitor CHEMBL501005 family 2 2
4'-phosphopantetheinyl transferase ffp and Beta-lactamase inhi... 1 0
Tubulin beta-1 chain inhibitor SureCN6672529 family 1 0
Neuraminidase inhibitor AC1NQT84 family 2 0
tanedioate NP ZINC08790785 Family 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00184838 CHEMBL2332367 Bioactive 2-[(2S,5R,8S,11S)-8-(4-aminobutyl)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid
CFAMM00184772 CHEMBL2371899 Bioactive 2-[(2S,5R,8S,11S)-5,8-dibenzyl-11-[3-(diaminomethylideneamino)propyl]-8-(difluoromethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid
CFAMM00184845 CHEMBL2448543 Bioactive 2-[(2S,5R,8R,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-7-methyl-8-(2-methylpropyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid
CFAMM00184821 CHEMBL317887 Bioactive 2-[(2R,5R,8R,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid;2,2,2-trifluoroacetic acid
CFAMM00184826 CHEMBL431829 Bioactive 2-[(2R,5R,8R,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-10-methyl-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid
CFAMM00184763 CHEMBL2373037 Bioactive 2-[(2S,8S,11S,14S)-14-benzyl-8-[3-(diaminomethylideneamino)propyl]-13-methyl-3,6,9,12,15-pentaoxo-11-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid
CFAMM00184769 DNC006253 Investigative Drug c[RGDf-(R)-alpha-TfmV]
CFAMM00184791 DNC006247 Investigative Drug c[RGDf-(S)-N-Me-alpha-TfmF]
CFAMM00184774 DNC006254 Investigative Drug c[RGDf-(S)-alpha-TfmV]
CFAMM00184790 DNC006246 Investigative Drug c[RGDf-(R)-N-Me-alpha-TfmF]
CFAMM00184773 DNC003981 Investigative Drug CYCLORGDFV
CFAMM00184788 DNC006249 Investigative Drug c[RGD-(S)-alpha-TfmfV]
CFAMM00184803 DNC006250 Investigative Drug c[RGDf-(S,R)-alpha-Dfm-F]
CFAMM00184787 DNC006248 Investigative Drug c[RGD-(R)-alpha-TfmfV]
CFAMM00184771 DNC006251 Investigative Drug c[RGDf-(R)-alpha-TfmF]
CFAMM00184858 DNC000432 Investigative Drug Cilengitide
CFAMM00184770 DNC006252 Investigative Drug c[RGDf-(S)-alpha-TfmF]

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26846 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543