CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2340
Family Name Beta-secretase 1 Inhibitor KMI-538 Family
No. of Seeds 4 No. of Other Members 20
Family Centroid CFAMM00265932 Functional Category Investigative Drug
Superfamily Penicillin binding protein Inhibitor Ertapenem Superfamily
Class Class 257

Cousin Family NamesSeedsMembers
Cholecystokinin receptor type A Ligand Gi 181771 Family 3 18
Kappa-type opioid receptor Ligand Asimadoline Family 14 54
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 36 15
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Beta-secretase 1 Inhibitor GSK-188909 Family 16 11
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 4 1
Beta-secretase 1 and Cathepsin D inhibitor 3ixk family 2 9
Beta-secretase 1 and Cathepsin D inhibitor 3ixj family 10 21
Beta-secretase 1 and Cathepsin D inhibitor 3-(4-chloro-N-methy... 1 0
Cathepsin B inhibitor 3-[[(2R)-2-cyano-2-[[(2S)-3-(3-methylphe... 6 8
Cathepsin B and Cathepsin L1 inhibitor 3-[[(2R)-2-cyano-2-[[(2... 3 4
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 5 2
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 1
Stromelysin-1 inhibitor 6-(4'-FLUORO-BIPHENYL-4-YL)-4-(3-METHY... 3 0
Chymase and Chymotrypsin-C inhibitor 3-[[2,2-difluoro-4-[[(2S)... 6 10
Chymase and Chymotrypsinogen A inhibitor 3-[[4-[[(2S)-1-[(2S)-... 1 0
Beta-secretase 1 inhibitor KMI-420 family 1 6
Cathepsin D and Cathepsin E inhibitor methyl (2S)-1-[(2R)-2-[[... 1 0
C-C chemokine receptor type 3 ligand 1-(3-acetylphenyl)-3-[3-[... 9 1
Beta-secretase 1 inhibitor CHEMBL400438 family 5 16
Chymase and Chymotrypsin-C inhibitor 3-[[4-[[2-[5-amino-2-(3-m... 1 4
Dihydrofolate reductase inhibitor AGN-PC-073POJ family 1 0
Cathepsin B and Cathepsin L1 inhibitor 5-[[(2R)-2-[[(2S)-2-ani... 1 0
Coagulation factor X and Tissue factor inhibitor AGN-PC-02WN8Y... 7 22
Cathepsin B inhibitor 3-[[(2R)-2-cyano-2-[[(2S)-3-(3-methylphe... 1 0
fMet-Leu-Phe receptor ligand N-[2-(2,6-dimethylanilino)-1-(2,3... 1 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[[1... 2 5
Protein farnesyltransferase subunit beta and Protein farnesylt... 2 4
Tyrosine-protein phosphatase non-receptor type 1 and Tyrosine-... 2 11


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00265934 CHEMBL288713 Bioactive 5-[[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(carboxyamino)propanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-2-hydroxy-4-phenylbutanoyl]amino]benzene-1,3-dicarboxylic acid
CFAMM00265931 CHEMBL181826 Bioactive KMI-370
CFAMM00265933 DNC007743 Investigative Drug KMI-494
CFAMM00265932 DNC007742 Investigative Drug KMI-538

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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