CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID235
Family Name CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilostamide Family
No. of Seeds 6 No. of Other Members 202
Family Centroid CFAMM00185018 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilostamide Superfamily
Class Class 1484

Cousin Family NamesSeedsMembers
SUR1-type K(ATP) channel and SUR2-type K(ATP) channel Ligand R... 1 16
Beta-1 adrenergic receptor Ligand Acebutolol Family 2 27
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Beta-1 adrenergic receptor Ligand Practolol Family 2 82
Acyl-CoA desaturase Inhibitor Isoxyl Family 5 62
Histamine H1 receptor Ligand Tranilast Family 5 125
Stromelysin-1 Inhibitor PG-530742 Family 4 23
D(2) dopamine receptor Ligand Aplindore Fumarate Family 2 30
D(4) dopamine receptor Ligand PD-165167 Family 2 96
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
Tasquinimod family 1 4
Cinitapride family 4 22
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
Neuropeptide Y receptor type 1 Ligand BMS-193885 Family 3 11
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
C-C chemokine receptor type 1 Ligand BX-471 Family 10 67
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Tubulin Inhibitor WR85915 Family 3 15
Arachidonate 5-lipoxygenase Inhibitor ZM-230487 Family 3 23
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
Poly [ADP-ribose] polymerase 1 Inhibitor 3-methoxybenzamide Fa... 2 23
Mineralocorticoid receptor and Androgen receptor Ligand AL-43 ... 79 235
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 20
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor Liga... 40 90
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Potassium ... 1 15
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Oxytocin receptor and Vasopressin V1a receptor Ligand L-371257... 8 92
MO15-related protein kinase Pfmrk Inhibitor 3-[3-(2-hydroxy-et... 1 6
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Cytochrome P450 1B1 Inhibitor N-(2,4-dimethoxy-phenyl)-3,5-dim... 1 110
Histamine H3 receptor Ligand A-349821 Family 49 228
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Alpha-1A adrenergic receptor Ligand Ro-11-04253 Family 1 1
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Oxysterols receptor LXR-alpha Ligand N-{4-[2-(4-methoxyphenyl)... 3 16
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 2 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Liver carboxylesterase 1 Inhibitor 5-(trifluoromethoxy)-1h-ind... 3 12
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 11 13
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Macrophage migration inhibitory factor Inhibitor Benzofuran-2-... 5 67
Sodium channel protein type 10 subunit alpha and Sodium channe... 2 13
Multidrug resistance protein 1 and Multidrug resistance-associ... 3 55
Amine oxidase [flavin-containing] B Inhibitor N-methyl-n-pheny... 6 25
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 12 44
Urotensin-2 receptor Ligand SB-436811 Family 6 71
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Renin Inhibitor Ro-66-1168 Family 10 30
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Fatty-acid amide hydrolase 1 Inhibitor 2-fluorophenyl 4-(octyl... 15 9
Fatty-acid amide hydrolase 1 Inhibitor Benzaldehyde O-4-ethoxy... 21 4
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 16
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Beta-ketoacyl-acyl carrier protein synthase III Inhibitor 2-(4... 2 6
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Fatty-acid amide hydrolase 1 Inhibitor 4-nitrophenyl 4-benzylp... 5 35
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 28 91
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Vasopressin V1a receptor and Vasopressin V2 receptor ligand N-... 1 2
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Stromelysin-1 and 72 kDa type IV collagenase inhibitor [(2S)-2... 2 2
Beta-secretase 1 inhibitor SureCN8235614 family 4 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
Beta-1 adrenergic receptor ligand 1-[2-[[(2S)-3-(2-cyanophenox... 10 4
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 5
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 3 13
Poly [ADP-ribose] polymerase 1 inhibitor 6-[1-(2,3-dihydro-1,4... 1 30
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 6
Disintegrin and metalloproteinase domain-containing protein 17... 3 0
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-3... 2 3
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Kappa-type opioid receptor ligand AGN-PC-09M90I family 2 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
D(3) dopamine receptor and D(1A) dopamine receptor ligand N-[(... 6 14
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 1 0
Renin inhibitor 6-[[(2R)-1-[4-[3-[(2-methoxyphenyl)methoxy]pro... 3 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Transient receptor potential cation channel subfamily V member... 3 15
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 1
Survival motor neuron protein and DNA-(apurinic or apyrimidini... 1 5
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 3 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Nuclear receptor ROR-gamma and Menin ligand CHEMBL1432265 family 1 18
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 7 4
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 7 9
Substance-P receptor ligand (2S,4S)-1-N-(3-chlorophenyl)-2-N-[... 5 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
Neuropeptide S receptor and Survival motor neuron protein liga... 1 2
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
Thyroid hormone receptor beta ligand SureCN8800248 family 3 10
Prelamin-A/C and Cruzipain inhibitor CHEMBL1598118 family 1 3
Survival motor neuron protein and Alpha-galactosidase A inhibi... 1 4
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 11 26
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
Gastrin/cholecystokinin type B receptor ligand 1-[3-[[2-(3-met... 2 12
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Melanin-concentrating hormone receptor 1 ligand 1-[1-(1-methyl... 5 10
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 3 2
Prostaglandin D2 receptor 2 ligand SureCN136287 family 1 9
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QMLE family 5 0
Trace amine-associated receptor 1 ligand EPPTB family 4 9
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor N-[(1S,5aR,9... 2 2
Vasopressin V1b receptor ligand AGN-PC-09QGT9 family 4 123
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Leukotriene A-4 hydrolase inhibitor AGN-PC-0A9QDC family 2 5
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 1
Coagulation factor VII and Prothrombin inhibitor (S)-[(R)-2-(4... 2 8
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 1
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand CHEMB... 13 20
Substance-P receptor ligand 1-[(5-amino-2-methoxyphenyl)methyl... 3 5
Neuropeptide Y receptor type 5 ligand 2-(7-chloro-3-oxo-1,4-be... 3 3
Histamine H3 receptor ligand SureCN1373218 family 2 2
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 2 4
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Histamine H3 receptor ligand 1-methyl-5-[4-[3-[(2R)-2-methylpy... 5 5
Histamine H3 receptor ligand 5-[4-[3-[(2R)-2-methylpyrrolidin-... 2 3
Melanin-concentrating hormone receptor 1 and Potassium voltage... 3 6
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
Cathepsin S and Cathepsin K inhibitor arylaminoethyl amide, 7 ... 2 0
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Growth hormone secretagogue receptor type 1 ligand 2-[(2S)-1-[... 2 0
Sphingosine 1-phosphate receptor 1 ligand 2-methoxy-N-[(4-phen... 2 23
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 4 2
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-[(4... 10 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 0
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial ... 3 3
Translocator protein inhibitor [11C]DAA1106 family 15 2
Microsomal triglyceride transfer protein large subunit inhibit... 3 0
Translocator protein inhibitor N-methyl-2-[2-oxo-5-[4-(trifluo... 9 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 3
Cathepsin S and Cathepsin K inhibitor SureCN3018173 family 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand CHEMB... 6 3
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 0
Cathepsin K inhibitor (1R,2R)-N-(cyanomethyl)-2-[4-(3-methoxyp... 2 1
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(1-cyanocyclop... 4 0
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 2 1
Integrin beta-3 and Integrin alpha-2 inhibitor 3-(4-methoxyphe... 4 6
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
Bifunctional epoxide hydrolase 2 inhibitor SureCN3178516 family 3 1
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
5-hydroxytryptamine receptor 1B ligand SureCN5352760 family 2 5
Sodium-dependent serotonin transporter and D(2) dopamine recep... 8 6
C-C chemokine receptor type 1 ligand N-[2-[(2S)-3-(5-chlorospi... 4 0
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2-chloro-5-... 3 0
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltra... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 8
Histamine H3 receptor and Histamine receptor H3 ligand 1-[4-[3... 2 0
Histamine H3 receptor and Histamine receptor H3 ligand 1-(3,5-... 1 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 10
Bifunctional epoxide hydrolase 2 and RAF proto-oncogene serine... 4 10
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-fluoro-5-hydro... 2 0
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-ethylbutanoyl)... 11 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 5
Glutamate receptor ionotropic, NMDA 2B and Potassium voltage-g... 2 1
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 7 1
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 20 23
Progesterone receptor ligand CHEMBL252850 family 2 0
Androgen receptor ligand tert-butyl 4-methyl-2,5-dioxo-1H-chro... 3 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
Delta-type opioid receptor and Kappa-type opioid receptor liga... 5 0
D(3) dopamine receptor and D(4) dopamine receptor ligand SureC... 3 19
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 7
5-hydroxytryptamine receptor 1A ligand 3-hydroxy-6-iodo-2-[2-[... 2 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 11 4
C-C chemokine receptor type 5 ligand dimethyl-[[4-[[7-(4-methy... 7 8
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Hormone-sensitive lipase inhibitor SureCN7553414 family 1 1
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 10
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 4 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
Neuropeptide Y receptor type 5 ligand 3-[4-(4-fluorophenoxy)ph... 4 0
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZ6 family 3 6
Substance-P receptor ligand CP 141938 family 1 0
Melanin-concentrating hormone receptor 1 ligand N-methyl-N-[(3... 2 2
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 13
Sigma non-opioid intracellular receptor 1 ligand (5S)-5-[(4-hy... 1 5
D(3) dopamine receptor ligand rac S 33138 family 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-00RZQT family 3 4
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KJY family 5 4
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KFD family 1 1
Leukotriene A-4 hydrolase inhibitor 4-[[(1S,5R)-3-[4-(2-fluoro... 2 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 28 30
Mitogen-activated protein kinase 14 inhibitor SureCN4822166 fa... 1 4
Leukotriene A-4 hydrolase inhibitor SureCN5313952 family 4 1
Growth hormone secretagogue receptor type 1 ligand N-[4-[(2S)-... 1 0
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Hormone-sensitive lipase inhibitor [4-[(4-tert-butylcyclohexan... 2 1
Renin inhibitor N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy... 5 1
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 1 0
Cathepsin E and Cathepsin D inhibitor SureCN2529506 family 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
fMet-Leu-Phe receptor ligand 2-[[(2S)-2-[[(2S)-2-[(4-methoxyph... 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor SureCN8058778 family 13 4
Progesterone receptor ligand AGN-PC-080PVV family 3 3
Beta-1 adrenergic receptor and Beta-3 adrenergic receptor liga... 2 0
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8797384 f... 1 0
Histone deacetylase 8 and Histone deacetylase 6 inhibitor (3S)... 4 16
Amine oxidase [flavin-containing] B and Adenosine receptor A2b... 2 2
Follicle-stimulating hormone receptor ligand (1-acetyl-2,2,4-t... 1 2
Caspase-3 inhibitor AGN-PC-00ELYM family 3 2
Sodium channel protein type 9 subunit alpha ligand SureCN12900... 9 8
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 0
Histone deacetylase 1 and Histone deacetylase 2 inhibitor Sure... 2 0
Matrix metalloproteinase-9 and Metalloproteinase inhibitor 3 i... 1 3
Metabotropic glutamate receptor 2 ligand (5R)-3-[[4-(4-ethoxyp... 3 9
Major prion protein and Microtubule-associated protein tau inh... 2 10
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 2 0
Retinol-binding protein 4 inhibitor methyl 2-[4-[[(2E,4E,6E,8E... 1 0
Mitogen-activated protein kinase 14 inhibitor SureCN6679437 fa... 1 0
Hypoxia-inducible factor 1-alpha inhibitor 2-morpholin-4-yleth... 2 0
Isoprenyl transferase inhibitor 2-benzyl-4-hydroxy-6-oxo-N-(4-... 1 0
Sodium channel protein type 1 subunit alpha and Sodium channel... 3 0
Coagulation factor X inhibitor 3,4-dimethoxy-N-[N-(4-methoxyph... 3 0
Histone deacetylase 1 and Histone deacetylase 2 inhibitor 4-[3... 4 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 0
Amino Acids and Derivatives Metabolite 5-Hydroxy-N-formylkynur... 3 3
NP 7-hydroxy-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1h)-one Family 2 0
NP (s)-3-(2,5-dioxo-2,3,4,5-tetrahydro-1h-benzo[e][1,4]diazepi... 3 0
dimethyl 5-[[2-(3,4,7,8,9,10-hexahydro-2H-[1,4]dioxepino[2,3-g... 1 0
methoxybenzoate NP (2-hydroxy-6-methoxyquinolin-3-yl)methyl 4-... 2 1
N-(4-acetamidophenyl)-2-(2,2-dimethyl-3,4-dihydrochromen-6-yl)... 1 0
1-(3-methoxyphenyl)-5-oxo-N-(2-oxochromen-6-yl)pyrrolidine-3-c... 2 0
4-(4-methoxyphenyl)-2,4,5,10-tetrahydro-1H-pyrrolo[3,4-c][1,5]... 4 0
[3-[(E)-3-(4-methoxyphenyl)-3-oxoprop-1-enyl]phenyl] N,N-diphe... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00185048 CHEMBL1642486 Bioactive AGN-PC-09QM7C
CFAMM00184951 CHEMBL433864 Bioactive AGN-PC-075LKF
CFAMM00185018 DNC000433 Investigative Drug Cilostamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24650 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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