CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2359
Family Name Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phenoxy)picolinamide Family
No. of Seeds 3 No. of Other Members 27
Family Centroid CFAMM00266587 Functional Category Investigative Drug with Natural Product
Superfamily Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phenoxy)picolinamide Superfamily
Class Class 2433

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
HIV protease Inhibitor Indinavir Family 36 211
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Cathepsin K Inhibitor Relacatib Family 26 32
Cannabinoid receptor 1 Ligand Taranabant Family 20 30
Histamine H3 receptor Ligand GSK239512 Family 2 65
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Neuronal acetylcholine receptor subunit alpha-4 Ligand TC-5619... 3 61
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
DCC-2036 family 2 5
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
C-C chemokine receptor type 2 and C-C motif chemokine 2 Ligand... 3 52
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Chymase Inhibitor NK3201 Family 1 0
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Leukotriene B4 receptor 1 Ligand SB-201993 Family 5 13
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Alpha-1A adrenergic receptor Ligand A-131701 Family 16 17
D(2) dopamine receptor Ligand SLV-314 Family 19 69
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
5-hydroxytryptamine receptor 3A and Neuronal acetylcholine rec... 1 3
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
Gonadotropin-releasing hormone receptor ligand 1-[(2,6-difluor... 6 31
Histamine H3 receptor and Potassium voltage-gated channel subf... 5 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 1 0
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-[3-cy... 2 5
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(2-methoxy-3-methylpy... 2 3
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 2 15
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
B2 bradykinin receptor ligand SureCN6640854 family 7 4
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Cathepsin S and Cathepsin K inhibitor N-[(2S)-3-(1-methylcyclo... 2 0
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cytochrome P450 2C19 and Inositol monophosphatase 1 inhibitor ... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 2 6
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Serine/threonine-protein kinase B-raf inhibitor furan-based co... 6 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 1 14
Renin inhibitor [2-(3-fluoro-2,6-dimethylphenoxy)-1-phenylpyrr... 5 12
Histamine H3 receptor ligand 3-[4-[3-[(2R)-2-methylpyrrolidin-... 1 5
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 1
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 2
D(2) dopamine receptor and D(3) dopamine receptor ligand N-[3-... 7 3
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
C-C chemokine receptor type 5 ligand 6-cyano-N-[(3R)-3-[4-[N-[... 3 0
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 2 5
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 3 16
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Beta-1 adrenergic receptor ligand N-[2-[[(2S)-3-(2-cyanophenox... 2 1
Cholinesterase and Acetylcholinesterase inhibitor 4-oxo-N-[9-(... 11 13
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[(1... 2 0
Histamine H3 receptor ligand 6-[[2-[2-[(2R)-2-methylpyrrolidin... 2 0
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 3 1
Arachidonate 5-lipoxygenase inhibitor 7-[[3-fluoro-5-(1-hydrox... 1 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Plasmepsin-2 and Cathepsin D inhibitor 4-[4-[[(2S,3S)-1-[[(3S,... 3 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 159
Motilin receptor ligand SureCN2768193 family 2 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Disintegrin and metalloproteinase domain-containing protein 17... 5 4
C-C chemokine receptor type 5 ligand N-methyl-4-[6-methyl-5-[[... 2 2
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Prothrombin and Coagulation factor X inhibitor N-[3-[(3-fluoro... 1 8
Glutamate receptor ionotropic, NMDA 2B ligand SureCN5532501 fa... 1 0
Macrophage colony-stimulating factor 1 receptor ligand 5-cyano... 1 0
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Pol polyprotein inhibitor Palinavir deriv. 13 family 1 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
Cathepsin K and Cathepsin L1 inhibitor AC1NR9VX family 2 2
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Substance-P receptor ligand SureCN2139814 family 7 7
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
KiSS-1 receptor ligand [2-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S... 1 1
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
CGMP-dependent protein kinase inhibitor AGN-PC-075IHL family 2 8
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 6 1
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 2 2
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 5 1
Collagenase 3 inhibitor SureCN1316041 family 4 3
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Pol polyprotein inhibitor N-benzyl-2,2-difluoro-4-[[(2S)-3-met... 1 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 3
Prothrombin inhibitor N-[(2S)-3-(4-aminophenyl)-1-[4-(2-fluoro... 7 4
Platelet-activating factor receptor ligand [(2R,4R)-4-(octadec... 3 2
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 2 3
Sodium channel protein type 9 subunit alpha and Sodium channel... 1 1
Beta-secretase 2 and Beta-secretase 1 inhibitor N-[3-[(4R)-2-a... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Cytochrome P450 1A2 and Metabotropic glutamate receptor 4 liga... 1 2
Thromboxane-A synthase and Platelet-activating factor receptor... 1 6
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 1
Butyrylcholinesterase and Muscarinic acetylcholine receptor M2... 1 0
NP 5-((4-chlorobenzyl)oxy)-2-(6,7-dimethoxy-1,2,3,4-tetrahydro... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00266591 CHEMBL557054 Bioactive SureCN467158
CFAMM00266587 DNC007800 Investigative Drug 6-(4-(2-(benzylamino)ethyl)phenoxy)picolinamide
CFAMM00266592 DNC007803 Investigative Drug 5-(4-((phenethylamino)methyl)phenoxy)picolinamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26830 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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