CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID236
Family Name Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat Family
No. of Seeds 7 No. of Other Members 50
Family Centroid CFAMM00185229 Functional Category Investigative Drug with Natural Product
Superfamily P2X purinoceptor 3 and Oxysterols receptor LXR-beta Binder Superfamily
Class Class 1412

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Peroxisome proliferator-activated receptor alpha Ligand Bezafi... 2 17
Beta-2 adrenergic receptor Ligand Salmeterol Xinafoate Family 9 51
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Cholesteryl ester transfer protein Inhibitor Anacetrapib Family 3 63
C-C chemokine receptor type 2 Ligand CCX915 Family 3 25
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Integrin alpha-4 Inhibitor Firategrast Family 3 93
Sigma non-opioid intracellular receptor 1 Ligand SSR-125047 Fa... 1 2
Microsomal triglyceride transfer protein large subunit Inhibit... 3 103
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
P2X purinoceptor 3 Inhibitor A-317491 Family 1 2
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Leukotriene B4 receptor 1 Ligand SC-51146 Family 6 315
Peroxisome proliferator-activated receptor gamma and Peroxisom... 2 4
Histamine H3 receptor Ligand A-349821 Family 49 228
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 33
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 20 8
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 8 12
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Endothelin-1 receptor and Endothelin B receptor ligand (2R,3R,... 3 2
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Caspase-1 inhibitor 5-(3-carbamoylnaphthalen-2-yl)oxy-3-[[(2S)... 1 11
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
Leukotriene B4 receptor 1 ligand AGN-PC-00GEAR family 2 2
Type-2 angiotensin II receptor ligand SureCN244657 family 7 11
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-7-[(4-ca... 3 14
Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor liga... 12 0
Prostaglandin D2 receptor 2 ligand SureCN137334 family 1 0
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 2 6
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Prostaglandin E2 receptor EP4 subtype ligand 4-[(1S)-1-[[2-(tr... 2 1
Prostaglandin D2 receptor 2 and Chemoattractant receptor-homol... 3 5
Prostaglandin D2 receptor 2 and Chemoattractant receptor-homol... 1 1
Growth hormone secretagogue receptor type 1 ligand 2-[(2S)-1-[... 2 0
Free fatty acid receptor 1 ligand 3-[4-[[3-[2,6-dimethyl-4-[3-... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
Estrogen receptor ligand 2-(3-hydroxy-6-oxoxanthen-9-yl)-5-[[4... 1 2
Glucagon receptor and Gastric inhibitory polypeptide receptor ... 1 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 13 0
Estrogen receptor and Estrogen receptor beta ligand SureCN1450... 1 1
Caspase-1 inhibitor (3S)-3-[2-[3-(naphthalene-1-carbonylamino)... 13 5
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 14 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 3 14
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Estrogen receptor beta and Estrogen receptor ligand AGN-PC-074... 5 4
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 2
Growth hormone secretagogue receptor type 1 ligand SureCN76477... 2 1
Melanin-concentrating hormone receptor 1 ligand N-methyl-N-[(3... 2 2
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-04X9O... 2 1
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 16 2
Histamine H3 receptor and D(3) dopamine receptor ligand AGN-PC... 1 0
Histamine H3 receptor ligand SureCN3945230 family 3 3
Free fatty acid receptor 1 ligand (3R,4R)-3-[4-(3,4-dimethylph... 4 4
Kappa-type opioid receptor ligand N-[(1S)-2-[(3S)-3-hydroxypyr... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor AGN-PC-074LOQ... 3 0
Arachidonate 5-lipoxygenase inhibitor methyl 5-[1-(2-butyl-1-b... 2 4
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 4 3
Metabotropic glutamate receptor 2 ligand SureCN787402 family 1 8
Prostaglandin D2 receptor 2 and Chemoattractant receptor-homol... 2 0
Arachidonate 5-lipoxygenase and Arachidonate 15-lipoxygenase i... 1 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 3
Putative NP ZINC04061066 Family 18 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00185197 CHEMBL95908 Bioactive AGN-PC-074RW9
CFAMM00185183 CHEMBL592213 Bioactive AGN-PC-03XH6T
CFAMM00185187 CHEMBL125214 Bioactive (2E)-2-[[4-[2-[methyl(2-phenylethyl)amino]-2-oxoethyl]-8-phenylmethoxynaphthalen-2-yl]methylidene]butanoic acid
CFAMM00185228 CHEMBL1668894 Bioactive SureCN134982
CFAMM00185193 CHEMBL1941128 Bioactive 2-[3-[3-[benzoyl(3,3-diphenylpropyl)amino]propyl]phenoxy]acetic acid
CFAMM00185229 DNC000434 Investigative Drug Cinaciguat

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

42891 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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