CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2363
Family Name D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-198 Family
No. of Seeds 5 No. of Other Members 27
Family Centroid CFAMM00266707 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily D(2) dopamine receptor and D(3) dopamine receptor Binder Superfamily
Class Class 246

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Alpha-1B adrenergic receptor ligand phenethylamine derivative ... 12 283
5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680
Adrenergic neuron Inhibitor guanidine isoquinoline analog Debr... 2 44
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Extracellular calcium-sensing receptor ligand Cinacalcet Family 2 30
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Sodium channel protein type 5 subunit alpha Ligand Indecainide... 2 41
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Squalene monooxygenase Inhibitor Naftifine Family 8 32
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diet... 29 276
DNA Binder Procarbazine Family 8 358
Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45
Noradrenergic re-uptake Inhibitor Maprotiline Family 6 33
Noradrenergic re-uptake Inhibitor Milnacipran Family 7 51
Serotonin re-uptake Inhibitor Dexfenfluramine Family 6 31
Peripheral carotid chemoreceptor Ligand Doxapram Family 4 36
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Motilin receptor Ligand GSK962040 Family 30 457
Substance-P receptor Ligand Orvepitant Family 11 46
Glutamate receptor AMPA subtype and Noradrenaline uptake Ligan... 9 17
Substance-P receptor Ligand Vestipitant Family 14 137
Bavisant family 9 65
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Reverse transcriptase Inhibitor 3-benzylamino-5-ethyl-6-methyl... 2 24
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Neutrophil elastase Inhibitor FK-706 Family 8 85
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Renin Inhibitor N-methyl-n-(methylbenzyl)formamide Family 2 17
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Carbonic anhydrase 2 Inhibitor N-benzyl-4-sulfamoyl-benzamide ... 12 44
Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phen... 3 12
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Poly [ADP-ribose] polymerase 1 Inhibitor 3,4-dihydro-5-methyl-... 3 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Histone deacetylase 1 Inhibitor 8-(3-benzoyl-ureido)-octanoic ... 7 13
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(6... 1 12
Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 1 3
Caspase-3 Inhibitor 2-phenethylisoquinoline-1,3,4-trione Family 6 0
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Tic... 11 31
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondria... 2 3
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... 10 22
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 11 6
Histamine H3 receptor Ligand N-benzyl-4-cyclopentylpiperazine-... 3 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Serine/threonine-protein kinase Chk1 Inhibitor 6-(3-aminopropy... 2 7
Calcium-activated potassium channel subunit alpha-1 Ligand N-m... 2 10
Sodium-dependent serotonin transporter Inhibitor 1-(2-(naphtha... 5 2
Poly [ADP-ribose] polymerase 1 Inhibitor 5-aminoisoquinolin-1(... 2 8
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... 6 19
Fatty-acid amide hydrolase 1 Inhibitor 1-biphenyl-4-ylmethylma... 2 2
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Inhibit... 5 23
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Cathepsin S Inhibitor N-(1-oxobutan-2-yl)-3-(trifluoromethyl)b... 2 10
Aminopeptidase N Inhibitor N1,2-dibenzyl-n3-hydroxymalonamide ... 5 23
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-benza... 3 9
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Sodium-dependent serotonin transporter Inhibitor Irindalone Fa... 16 9
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 80
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 1
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 6
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 17 9
Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... 8 13
Aminopeptidase N Inhibitor 2-amino-n1-benzyl-n3-hydroxymalonam... 3 4
Aminopeptidase N Inhibitor 2-benzyl-n1-hydroxy-n3-(4-phenylbut... 5 3
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 4
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
DNA topoisomerase Inhibitor 6-benzylamino-1h-pyrimidine-2,4-di... 3 3
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand N-(3-... 1 7
Sigma non-opioid intracellular receptor 1 ligand CHEMBL101300 ... 2 1
Substance-P receptor ligand AGN-PC-00FJ8P family 6 10
Substance-K receptor ligand 4-(4-methylphenyl)-N-[1-[[(2S)-5-[... 6 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 7 9
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 2
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 7
C-C chemokine receptor type 5 ligand AC1L9USC family 3 2
Kappa-type opioid receptor ligand 6-[2-oxo-2-[(2S)-2-(pyrrolid... 6 4
Kappa-type opioid receptor ligand 1-[(2S)-2-(pyrrolidin-1-ylme... 4 0
5-hydroxytryptamine receptor 7 and Sodium-dependent serotonin ... 5 1
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-2-[... 14 4
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 7 2
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 3
Survival motor neuron protein inhibitor CHEMBL1323700 family 1 4
D(1A) dopamine receptor and D(2) dopamine receptor ligand Sure... 2 0
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 3
Substance-P receptor ligand AGN-PC-075NRR family 2 1
Acetylcholinesterase inhibitor AC1MIM21 family 2 7
Neuromedin-K receptor ligand SureCN2477089 family 2 4
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 0
Mitogen-activated protein kinase 14 and Cytochrome P450 2C9 in... 2 0
Dipeptidyl peptidase 8 inhibitor (2S)-2-amino-4-[4-[bis(4-fluo... 2 9
Sigma non-opioid intracellular receptor 1 ligand 2-(3-bromophe... 5 1
Lysine-specific histone demethylase 1A and Amine oxidase [flav... 2 1
Substance-P receptor ligand (3S,4S)-N-[[3,5-bis(trifluoromethy... 8 9
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-cyc... 1 2
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 4 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 9 0
Substance-P receptor ligand (3R,4R)-1-(1-acetylpiperidine-4-ca... 9 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 9 0
C-C chemokine receptor type 2 ligand (2S)-N-[[3,5-bis(trifluor... 1 0
Histamine H3 receptor and Acetylcholinesterase ligand 1-[4-[[4... 1 2
Substance-P receptor ligand AGN-PC-073QYE family 6 11
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 3
Melanin-concentrating hormone receptor 1 and Potassium voltage... 4 4
C-C chemokine receptor type 2 ligand (1S,3R)-N-[[3-fluoro-5-(t... 22 27
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(cyanomethyl)-... 1 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 1
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
D-amino-acid oxidase inhibitor 3-hydroxy-5-(2-phenylethyl)-1H-... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 6
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 7
Follicle-stimulating hormone receptor ligand N-[[3-[4-[[(2S,5S... 7 0
Substance-P receptor and Potassium voltage-gated channel subfa... 5 1
Tryptase alpha/beta-1 and Trypsin-1 inhibitor AGN-PC-074JFM fa... 3 1
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 5
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 2
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 0
Melanocortin receptor 4 and Melanocortin receptor 3 ligand (2S... 2 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 1
Sodium-dependent noradrenaline transporter and Muscarinic acet... 1 2
Muscarinic acetylcholine receptor M3 ligand N-[[4-fluoro-3-[3-... 3 0
Bifunctional epoxide hydrolase 2 inhibitor SureCN14007258 family 2 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
Histamine H3 receptor ligand 1-[[3-(4-piperidin-1-ylbut-1-ynyl... 2 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
C-C chemokine receptor type 2 ligand (2S)-N-[[3,5-bis(trifluor... 1 1
Melanin-concentrating hormone receptor 1 ligand 1-[[4-(4-fluor... 2 10
Urease inhibitor 1-$l^{1}-selanyl-N,N-dimethyl-N'-[(1S)-1-naph... 1 0
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 1 1
Tyrosine-protein kinase Lck inhibitor 1-[2-[bis[3-[bis[3-[bis(... 1 0
Prelamin-A/C inhibitor CHEMBL1353052 family 1 1
Arachidonate 5-lipoxygenase inhibitor AGN-PC-075QQO family 1 1
Thioredoxin reductase 1, cytoplasmic inhibitor 5-fluoro-2-[2-(... 3 0
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 3 0
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 3 1
Styrenes Metabolite (E,E)-Lansamide I Family 2 0
Phenylpropenes Metabolite (E)-1-Cinnamoylpyrrolidine Family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00266696 CHEMBL2336352 Bioactive (E)-N-benzyl-3-phenylprop-2-enamide
CFAMM00266691 CHEMBL567944 Bioactive AGN-PC-00A7BC
CFAMM00266707 DNC007820 Investigative Drug ST-198

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26843 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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