Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.
Cousin Family Names Seeds Members Thyroid hormone receptor alpha ligand thyroid hormone analog L... 10 61 Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420 Retinoic acid receptor Ligand naphthoic acid derivative Adapal... 2 264 Histamine H1 receptor Ligand Doxepin Family 8 89 Serotonin re-uptake Inhibitor Fluoxetine Family 18 682 Lipoprotein lipase Inhibitor Gemfibrozil Family 1 28 Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74 Cyclooxygenase Inhibitor Fenoprofen Family 4 1077 Cyclooxygenase inhibitor salicylate derivative Aspirin family 3 234 Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267 Signal transducer and activator of transcription 3 Inhibitor A... 5 249 Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508 Tyrosinase Inhibitor Monobenzone Family 6 197 Oestrogen receptor ligand Dienestrol Family 35 440 Oestrogen receptor Ligand Chlorotrianisene Family 2 102 Sodium channel Ligand Permethrin Family 1 25 Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243 Peroxisome proliferator-activated receptor alpha Ligand Ciprof... 1 5 Tretinoin Tocoferil family 1 13 Ipriflavone family 62 2480 Salicin family 5 629 Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79 Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682 Steryl-sulfatase Inhibitor Stx 64 Family 7 160 Muscarinic acetylcholine receptor M1 Ligand GSK1034702 Family 7 148 Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33 cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123 Translocator protein Inhibitor Dextofisopam Family 3 250 Multidrug resistance protein Inhibitor Curcumin I Family 19 278 Free fatty acid receptor 1 Ligand TAK-875 Family 2 54 TS-071 family 8 36 Interleukin-1 beta Inhibitor Diacerein Family 3 77 Histamine H3 receptor Ligand UCL-2138 Family 23 172 Proto-oncogene tyrosine-protein kinase Src Inhibitor Malonic A... 1 34 Phospholipase A2 Inhibitor P-anisic Acid Family 2 178 Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126 Arachidonate 15-lipoxygenase Inhibitor Isoscopoletin Family 5 98 Platelet-activating factor receptor Ligand L-652731 Family 5 116 Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86 Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 7-(b... 4 42 Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 1,1,... 2 8 Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9 Coagulation factor X and Prothrombin Inhibitor 3-chlorophenyl ... 2 12 3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56 3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81 Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 127 Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 214 Prostaglandin D2 receptor 2 Ligand 2-(4-bromo-2-tert-butylphen... 3 4 NAD(P)H dehydrogenase [quinone] 1 Inhibitor NSC-106547 Family 3 65 Leukotriene A-4 hydrolase Inhibitor 1-butoxy-4-phenoxybenzene ... 3 85 Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80 Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 4-(1,... 3 31 Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 160 NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-amino-2h-chromen... 2 3 Prostaglandin D2 receptor 2 Ligand 2-(4-chloro-2-cyclohexylphe... 7 25 Prostaglandin D2 receptor 2 Ligand 2-(4-cyano-2-cyclohexylphen... 6 3 Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5 Kappa-type opioid receptor Ligand Anisocoumarin H Family 3 5 Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37 Androgen receptor Ligand 2-methoxy-4-(o-tolyloxy)benzonitrile ... 5 12 Androgen receptor Ligand 4-(m-tolyloxy)-2-(trifluoromethyl)ben... 7 65 Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 12 Thyroid hormone receptor alpha and Thyroid hormone receptor be... 5 8 Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74 Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32 Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28 Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16 Interleukin-8 Inhibitor 2-(2-(2-fluorophenoxy)phenyl)acetic Ac... 2 4 Aromatase Inhibitor NSC-122427 Family 1 0 NAD(P)H dehydrogenase [quinone] 1 Inhibitor Ethyl Bis(4-hydrox... 5 7 NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1 Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 6-meth... 2 36 Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29 Amine oxidase [flavin-containing] B Inhibitor 7-fluoro-2-p-tol... 4 11 Cytochrome P450 2D6 Inhibitor 4-methylaminomethyl-7-methoxycou... 3 80 Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86 Indoleamine 2,3-dioxygenase 1 Inhibitor 4-methoxybenzenemethan... 2 26 Amine oxidase [flavin-containing] B Inhibitor 8-bromo-6-methyl... 5 44 Prostaglandin G/H synthase 1 Inhibitor Acetic Acid 2-heptylsel... 1 14 Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-c... 5 72 5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5 Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 0 Prostaglandin G/H synthase 1 Inhibitor 2-(2-methoxyphenyl)-1h-... 1 11 Androgen receptor Ligand Palodesangren E Family 12 43 Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 27 Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 3 19 Retinoic acid receptor RXR-alpha and Peroxisome proliferator-a... 3 17 Prelamin-A/C and Solute carrier organic anion transporter fami... 1 15 Prostaglandin D2 receptor 2 and Chemoattractant receptor-homol... 4 37 Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 3 Carbonic anhydrase 1 and Carbonic anhydrase 14 inhibitor (NZ)-... 1 1 Free fatty acid receptor 1 ligand 3-[4-[[3-[4-(1,1-dioxothian-... 3 0 Peroxisome proliferator-activated receptor delta ligand SureCN... 1 0 Histone deacetylase 2 and Histone deacetylase 8 inhibitor 2-hy... 1 0 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R)... 1 4 Bloom syndrome protein and Survival motor neuron protein inhib... 2 1 Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 10 Steroidogenic factor 1 and Nuclear receptor subfamily 5 group ... 1 1 Prostaglandin D2 receptor 2 ligand 2-[2-[2-(2-chlorophenyl)eth... 1 0 Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor (4-met... 1 1 Free fatty acid receptor 1 ligand 3-[4-[2-[2-(cyanomethoxy)phe... 1 2 Free fatty acid receptor 1 ligand 3-[4-[2-[3-(trifluoromethoxy... 1 0 Prostaglandin G/H synthase 2 inhibitor AGN-PC-04VJ4H family 1 2 Thioredoxin glutathione reductase and Beta-lactamase inhibitor... 1 0 Steryl-sulfatase inhibitor [(8R,9S,13S,14S)-13-methyl-17-oxo-7... 1 9 Beta-lactamase inhibitor AGN-PC-0A9UJZ family 1 3 Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor propan... 3 5 Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 8 NS5B protein inhibitor (Z)-4-[2-(3-cyanopropoxy)phenyl]-4-hydr... 2 0 NS5B protein inhibitor SureCN3988565 family 2 4 Cannabinoid receptor 1 and Monoglyceride lipase ligand 4-(4-ph... 4 4 Carbonic anhydrase 9 and Carbonic anhydrase 12 inhibitor 5,10-... 1 0 Amine oxidase [flavin-containing] A inhibitor AGN-PC-02ON4B fa... 1 7 Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 2 4 Benzoxepines Metabolite 4,5-Dihydro-1-benzoxepin-3(2H)-one Family 1 2 Benzyloxycarbonyls Metabolite 4-Methoxybenzyl formate Family 1 7 Phenylacetic Acid Derivatives Metabolite Guaicyl phenylacetate... 1 3 Phenols and Derivatives Metabolite (±)-Flufenprox Family 1 13 Phenols and Derivatives Metabolite 2-(Ethoxymethyl)phenol Family 1 14 Putative NP ZINC31165975 Family 4 0 Putative NP ZINC04043753 Family 8 6 NP Agn-pc-05grlk Family 2 1 NP 4-(chloromethyl)-6-methoxy-2h-chromen-2-one Family 4 2 2-(2-methoxyphenyl)-5-oxooxolane-3-carboxylate NP ZINC00132596... 4 2 Putative NP ZINC04029250 Family 6 2 2-methyl-2H-chromene-3-carbaldehyde NP 2-methyl-2h-chromene-3-... 2 1 dimethylchromen-2-one NP 4-(chloromethyl)-6,7-dimethyl-2h-chro... 5 2 3-pentyl-5-(phenoxymethyl)oxolan-2-one NP ZINC02116245 Family 4 0 2-[(3,4-dimethoxyphenyl)methyl]propanedioate NP 4aji Family 1 0 5-(4-methoxyphenyl)-2,2-dimethyloxolan-3-one NP 5-(4-methoxyph... 2 0 NP 6-chloro-4-(chloromethyl)-5,7-dimethylchromen-2-one Family 1 0
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00267004
CHEMBL1957172
Bioactive
6-prop-2-enoxychromen-2-one CFAMM00267034
CHEMBL2115413
Bioactive
8-[[(4R)-6,6-dimethyl-4-bicyclo[3.1.1]heptanyl]methyl]chromen-2-one CFAMM00267016
CHEMBL1835829
Bioactive
6-(3,5-difluorophenyl)chromen-2-one CFAMM00266981
CHEMBL1835830
Bioactive
6-[3-(trifluoromethyl)phenyl]chromen-2-one CFAMM00267023
CHEMBL1957175
Bioactive
6-[tert-butyl(dimethyl)silyl]oxychromen-2-one CFAMM00266986
CHEMBL2114959
Bioactive
8-[[(4S)-6,6-dimethyl-4-bicyclo[3.1.1]heptanyl]methyl]chromen-2-one CFAMM00266991
CHEMBL1835827
Bioactive
6-(4-fluorophenyl)chromen-2-one CFAMM00266955
HMDB37709
Human Metabolite
4-Methylphenyl 3-methylbutanoate CFAMM00267007
HMDB33830
Human Metabolite
Cassiastearoptene CFAMM00266947
HMDB37680
Human Metabolite
2-Methylphenyl 2-methylpropanoate CFAMM00267006
HMDB36626
Human Metabolite
3,4-Dihydro-2H-1-benzopyran-2-one CFAMM00267011
ZINC00537545
Natural Product
6-tert-butyl-4-(chloromethyl)-2H-chromen-2-one CFAMM00267018
ZINC20761105
Natural Product
AGN-PC-05GRB9 CFAMM00267015
ZINC02113390
Natural Product
2-(2,2-dimethyl-3,4-dihydrochromen-6-yl)acetate CFAMM00266973
ZINC00489377
Natural Product
4-(chloromethyl)-6-methyl-2H-chromen-2-one CFAMM00267014
ZINC00541728
Natural Product
4-(CHLOROMETHYL)-6-ISOPROPYL-2H-CHROMEN-2-ONE CFAMM00267000
ZINC00517249
Natural Product
3-(2-oxopropyl)-2H-chromen-2-one CFAMM00266992
ZINC00489593
Natural Product
4-(chloromethyl)-7-methyl-2H-chromen-2-one CFAMM00266941
ZINC00542306
Natural Product
4-(chloromethyl)-6-ethyl-2H-chromen-2-one CFAMM00266978
ZINC36369862
Natural Product
AGN-PC-098XUC CFAMM00266939
ZINC32124351
Natural Product
(6-methyl-2-oxochromen-4-yl)methyl-(2-phenylethyl)phosphinate CFAMM00266970
23039114
Patent Compound
AGN-PC-03YBZ1 CFAMM00266984
21620755
Patent Compound
AGN-PC-03D9RH CFAMM00266997
11310274
Patent Compound
SureCN5702512 CFAMM00267012
572584
Patent Compound
2-Methylphenyl pivalate CFAMM00267028
11073974
Patent Compound
SureCN1126574 CFAMM00266977
53682073
Patent Compound
AGN-PC-09XEW3 CFAMM00266990
53834262
Patent Compound
AGN-PC-09ZECA CFAMM00266969
57010999
Patent Compound
AGN-PC-0BKMXS CFAMM00267019
57113608
Patent Compound
AGN-PC-0BO5OV CFAMM00266938
21910076
Patent Compound
AGN-PC-03HKML CFAMM00266983
56991121
Patent Compound
AGN-PC-0BLQ25 CFAMM00266996
520130
Patent Compound
Coumarin, 8-methoxy- CFAMM00267027
19747984
Patent Compound
AGN-PC-02JIJE CFAMM00266961
57196880
Patent Compound
AGN-PC-00MZGK CFAMM00266976
18472577
Patent Compound
AGN-PC-01WIRD CFAMM00266989
23513095
Patent Compound
8-methyl-2-chromanone CFAMM00267003
14999340
Patent Compound
AGN-PC-003AFO CFAMM00266953
4849037
Patent Compound
4-METHYLPHENYL 4-CHLOROBUTANOATE CFAMM00266968
21880388
Patent Compound
AGN-PC-03H3SS CFAMM00267033
19984581
Patent Compound
SureCN9855412 CFAMM00266995
20345575
Patent Compound
AGN-PC-02SKDK CFAMM00266982
54111197
Patent Compound
AGN-PC-0A30YD CFAMM00266944
57100948
Patent Compound
AGN-PC-0BNWQJ CFAMM00267010
57129631
Patent Compound
AGN-PC-0C257F CFAMM00267025
21993341
Patent Compound
SureCN7930814 CFAMM00266960
54390874
Patent Compound
AGN-PC-00NQSU CFAMM00266975
57063142
Patent Compound
AGN-PC-0BN5ZK CFAMM00266988
57114048
Patent Compound
AGN-PC-0BO606 CFAMM00267002
11275913
Patent Compound
AGN-PC-005T34 CFAMM00266950
11062925
Patent Compound
CFAMM00266967
22494675
Patent Compound
SureCN6133198 CFAMM00267032
54079306
Patent Compound
AGN-PC-0A2LUG CFAMM00266994
19988313
Patent Compound
AGN-PC-02Q8KB CFAMM00266943
15766523
Patent Compound
SureCN4059798 CFAMM00266959
14672036
Patent Compound
2(3H)-Benzofuranone, 7-(1,1-dimethylethyl)-3,3-dimethyl- CFAMM00266987
22116730
Patent Compound
AGN-PC-03KMDN CFAMM00266974
54003806
Patent Compound
AGN-PC-0A1MCL CFAMM00267001
22445805
Patent Compound
AGN-PC-03PP5B CFAMM00266949
271619
Patent Compound
2,6-di(propan-2-yl)phenyl carbonochloridate CFAMM00266966
9990085
Patent Compound
SureCN6830309 CFAMM00267031
20551612
Patent Compound
AGN-PC-02VCQQ CFAMM00266980
53980422
Patent Compound
phenyl (E)-dec-3-enoate CFAMM00266993
10879105
Patent Compound
CFAMM00267008
57000479
Patent Compound
AGN-PC-0BKFHV CFAMM00266942
13834970
Patent Compound
4-Methoxy-3-methylbiphenyl CFAMM00266958
57153648
Patent Compound
AGN-PC-0BOGA8 CFAMM00267022
22645977
Patent Compound
AGN-PC-03T0UF CFAMM00266965
21958141
Patent Compound
SureCN5646348 CFAMM00266979
54551577
Patent Compound
AGN-PC-02P5PV CFAMM00267030
56977301
Patent Compound
AGN-PC-0BLGAO CFAMM00266948
23267247
Patent Compound
1-phenoxy-4-prop-2-ynylbenzene CFAMM00266957
53950908
Patent Compound
AGN-PC-0A0XH5 CFAMM00267021
13668817
Patent Compound
SureCN253836 CFAMM00266972
57256385
Patent Compound
AGN-PC-0BQGCB CFAMM00266985
53875974
Patent Compound
SureCN10955728 CFAMM00266999
57053042
Patent Compound
AGN-PC-0BMYUD CFAMM00267013
22132020
Patent Compound
AGN-PC-03KUXL CFAMM00267029
54058005
Patent Compound
AGN-PC-0A2BSF CFAMM00266964
20404289
Patent Compound
SureCN10931314 CFAMM00266956
53795619
Patent Compound
AGN-PC-09YW3G CFAMM00267020
57293487
Patent Compound
AGN-PC-0BRNLV CFAMM00267035
53786880
Patent Compound
2-ethenyl-4H-chromene
Statistics of CFAM Database
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
48686 visits since 2014 .........
Dr.
Chen Yuzong
Deputy
Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore
All rights reserved.