CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2386
Family Name C-X-C chemokine receptor type 4 Ligand Cyclo(-d-tyr-l-ala-l-arg-l-nal-gly-) Family
No. of Seeds 25 No. of Other Members 23
Family Centroid CFAMM00267227 Functional Category Investigative Drug
Superfamily Mu-type opioid receptor Ligand Alvimopan Superfamily
Class Class 323

Cousin Family NamesSeedsMembers
Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472
Trypsin inhibitor polypeptide Aprotinin Family 7 68
Oxytocin receptor Ligand Oxytocin Family 30 182
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Growth hormone-releasing hormone receptor ligand polypeptide ... 14 34
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Zucapsacin family 7 177
Thymopentin family 20 133
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Plitidepsin family 15 5
Flovagatran family 12 546
Tryptase Inhibitor APC-366 Family 2 12
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 20 35
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU84687 F... 2 14
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Proto-oncogene tyrosine-protein kinase Src Inhibitor Glu-pro-g... 8 4
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Proto-oncogene tyrosine-protein kinase Src Inhibitor Y-c[d-pen... 20 66
Somatostatin receptor type 1 Ligand Des-aa1,2,5-[(nalphame)lys... 16 11
Integrin beta-3 Inhibitor Lamifiban Family 3 4
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 4-hy... 2 13
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 9 43
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 23 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 36 15
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 31 5
Mu-type opioid receptor and Nociceptin receptor Ligand Ac-ryyr... 60 11
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Prothrombin Inhibitor Cyclotheonamide E5 Family 3 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 8
Genome polyprotein Inhibitor Acasp-glu-cha-val-prb-cys Family 13 18
Genome polyprotein Inhibitor Acasp-glu-dif-ile-cha-cys-iqc-nle... 9 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 3 0
Sodium-dependent dopamine transporter Inhibitor Bip-tyr-thr-pr... 8 2
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 4
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 4
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Vasopressin V1a receptor Ligand Vasopressin Analogue Family 4 3
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 9
Interstitial collagenase and Low affinity immunoglobulin epsil... 1 1
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Cathepsin B and Calpain-2 catalytic subunit inhibitor AGN-PC-0... 2 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 2
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
C-X-C chemokine receptor type 4 ligand CHEMBL2012526 family 4 8
Plasminogen inhibitor (2S)-2-acetamido-5-(diaminomethylideneam... 1 0
Somatostatin receptor type 1 and Somatostatin receptor type 4 ... 2 0
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
KiSS-1 receptor ligand (2S)-N-[(2S)-1-[[(2S)-4-amino-1-[[(2S)-... 1 0
Mu-type opioid receptor ligand 4-[(2S)-3-[[(2S)-1-(4-hydroxyph... 2 6
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Neurotensin receptor type 1 ligand (2S)-2-[[(2S,3S)-2-[[(2S)-2... 2 1
Vasopressin V1a receptor and Vasopressin V1b receptor ligand C... 6 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-5-(diami... 2 0
C-X-C chemokine receptor type 4 ligand CHEMBL2372990 family 3 0
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4R)-4-(3-hydroxyp... 4 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 3
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Neprilysin inhibitor benzyl (2S)-3-(4-hydroxyphenyl)-2-[[2-(su... 1 1
Prothrombin inhibitor (2S)-1-[(2R)-2-amino-2-cyclohexylacetyl]... 2 1
Pol polyprotein inhibitor (2R)-5-[(3S,5R)-3,5-dibenzyl-2-oxopy... 3 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 3 0
Gonadotropin-releasing hormone receptor ligand (3R,6S,12S,15S,... 1 0
Neuropeptide Y receptor type 1 ligand (2R)-5-[[amino-[[2-[2-[2... 1 0
Somatostatin receptor type 2 and Somatostatin receptor type 3 ... 2 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 2
Beta-lactamase inhibitor sodium;(1R,5S)-4-[2-amino-2-(4-hydrox... 1 0
Signal transducer and activator of transcription 3 inhibitor [... 7 25
Genome polyprotein inhibitor (2S)-6-amino-N-[(2S)-6-amino-1-[[... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00267238 CHEMBL372874 Bioactive AC1NQU0Y
CFAMM00267262 CHEMBL1949737 Bioactive CHEMBL1949737
CFAMM00267268 CHEMBL219474 Bioactive 2-[3-[(2S,5S,8R,14S)-5-[3-(diaminomethylideneamino)propyl]-8-[(4-hydroxyphenyl)methyl]-14-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propyl]guanidine
CFAMM00267237 CHEMBL1949884 Bioactive CHEMBL1949884
CFAMM00267261 CHEMBL1949734 Bioactive CHEMBL1949734
CFAMM00267282 CHEMBL436283 Bioactive FC131
CFAMM00267267 CHEMBL2042117 Bioactive 2-[3-[(2S,5S,8S,14R)-12-amino-5-[3-(diaminomethylideneamino)propyl]-14-[(4-hydroxyphenyl)methyl]-8-(naphthalen-2-ylmethyl)-3,6,9,15-tetraoxo-1,4,7,10,13-pentazacyclopentadec-12-en-2-yl]propyl]guanidine
CFAMM00267236 CHEMBL1949885 Bioactive CHEMBL1949885
CFAMM00267260 CHEMBL1949738 Bioactive CHEMBL1949738
CFAMM00267266 CHEMBL2042119 Bioactive 2-[3-[(2S,5S,8R,14R)-9-amino-5-[3-(diaminomethylideneamino)propyl]-14-[(4-hydroxyphenyl)methyl]-8-(naphthalen-2-ylmethyl)-3,6,12,15-tetraoxo-1,4,7,10,13-pentazacyclopentadec-9-en-2-yl]propyl]guanidine
CFAMM00267219 CHEMBL218806 Bioactive 2-[3-[(2S,5R,8R,14S)-5-[3-(diaminomethylideneamino)propyl]-8-[(4-hydroxyphenyl)methyl]-4-methyl-14-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propyl]guanidine
CFAMM00267235 CHEMBL436097 Bioactive AC1NQTZJ
CFAMM00267259 CHEMBL1949739 Bioactive CHEMBL1949739
CFAMM00267265 CHEMBL2042118 Bioactive 2-[3-[(2S,5S,8S,14R)-9-amino-5-[3-(diaminomethylideneamino)propyl]-14-[(4-hydroxyphenyl)methyl]-8-(naphthalen-2-ylmethyl)-3,6,12,15-tetraoxo-1,4,7,10,13-pentazacyclopentadec-9-en-2-yl]propyl]guanidine
CFAMM00267258 CHEMBL192183 Bioactive AC1NQU0V
CFAMM00267264 CHEMBL1949730 Bioactive 2-[3-[(2R,5S,8S,14R)-5-[3-(diaminomethylideneamino)propyl]-14-[(4-hydroxyphenyl)methyl]-1-methyl-8-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propyl]guanidine
CFAMM00267257 CHEMBL1949740 Bioactive CHEMBL1949740
CFAMM00267223 CHEMBL370001 Bioactive 2-[3-[(4R,7S,10S,13S)-10-[3-(diaminomethylideneamino)propyl]-4-[(4-hydroxyphenyl)methyl]-13-(naphthalen-2-ylmethyl)-2,5,8,11,14-pentaoxo-1,3,6,9,12-pentazacyclotetradec-7-yl]propyl]guanidine
CFAMM00267263 CHEMBL1949731 Bioactive 2-[3-[(2S,5S,11R,14R)-14-(3-aminopropyl)-11-[(4-hydroxyphenyl)methyl]-13-methyl-5-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propyl]guanidine
CFAMM00267256 CHEMBL219339 Bioactive 2-[3-[(2S,5R,8R,14S)-5-[3-(diaminomethylideneamino)propyl]-8-[(4-hydroxyphenyl)methyl]-14-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]propyl]guanidine
CFAMM00267279 DNC007868 Investigative Drug TN-14003

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27430 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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