CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2389
Family Name Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-3-yl)benzamide Family
No. of Seeds 3 No. of Other Members 49
Family Centroid CFAMM00267331 Functional Category Investigative Drug with Natural Product
Superfamily Histone deacetylase 2 and Metabotropic glutamate receptor 5 Binder Superfamily
Class Class 281

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Histamine H1 receptor Ligand Tranilast Family 5 125
Darexaban Maleate family 1 13
Cinitapride family 4 22
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Receptor tyrosine-protein kinase erbB-2 Inhibitor Mini-antibod... 1 0
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Cytochrome P450 1B1 Inhibitor N-(2,4-dimethoxy-phenyl)-3,5-dim... 1 110
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Mitogen-activated protein kinase 14 and Serine/threonine-prote... 1 1
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Oxysterols receptor LXR-alpha Ligand N-{4-[2-(4-methoxyphenyl)... 3 16
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Fatty-acid amide hydrolase 1 Inhibitor Phenylcarbamic Acid Bip... 3 7
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxy-phenyl)-... 1 3
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Metabotropic glutamate receptor 5 Ligand N-(3-(3-cyanobenzamid... 2 13
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Gamma-aminobutyric acid receptor Ligand 2-(2-amino-phenyl)-6-m... 4 23
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Vasopressin V1a receptor and Vasopressin V2 receptor ligand N-... 1 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Stromelysin-1 and 72 kDa type IV collagenase inhibitor [(2S)-2... 2 2
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Nuclear receptor ROR-gamma and Menin ligand CHEMBL1432265 family 1 18
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 7 9
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
Prostaglandin D2 receptor 2 ligand SureCN136287 family 1 9
Trace amine-associated receptor 1 ligand EPPTB family 4 9
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Sphingosine 1-phosphate receptor 1 ligand 2-methoxy-N-[(4-phen... 2 23
Microsomal triglyceride transfer protein large subunit inhibit... 3 0
Mitogen-activated protein kinase 14 inhibitor Skepinone-L family 11 31
Mitogen-activated protein kinase 14 inhibitor N-[2,4-difluoro-... 4 1
Mitogen-activated protein kinase 14 inhibitor N-[2-fluoro-5-[(... 4 5
Integrin beta-3 and Integrin alpha-2 inhibitor 3-(4-methoxyphe... 4 6
Mitogen-activated protein kinase 14 inhibitor ethyl 3-(2,4-dif... 5 1
Adenosine receptor A3 and Adenosine receptor A1 ligand 4-metho... 3 1
Serine/threonine-protein kinase Chk1 inhibitor 9-(4-amino-3-me... 3 7
Serine/threonine-protein kinase Chk1 inhibitor 2-[9-(4-amino-3... 5 2
Serine/threonine-protein kinase Chk1 inhibitor 2,3-dimethoxy-9... 15 3
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
C-C chemokine receptor type 5 ligand dimethyl-[[4-[[7-(4-methy... 7 8
Capsid scaffolding protein inhibitor AC1MHP1L family 3 6
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-(3-methoxy-2-me... 2 4
Serine/threonine-protein kinase Chk1 inhibitor SureCN4849127 f... 4 1
Urokinase-type plasminogen activator and Trypsin-1 inhibitor A... 1 6
Mitogen-activated protein kinase 14 inhibitor SureCN4822166 fa... 1 4
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
Leukotriene A-4 hydrolase inhibitor SureCN5313952 family 4 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Follicle-stimulating hormone receptor ligand N-[(4R)-1-acetyl-... 2 0
Vascular endothelial growth factor receptor 2 ligand CHEMBL197... 1 1
Inosine-5'-monophosphate dehydrogenase 2 inhibitor SureCN32423... 1 0
Metabotropic glutamate receptor 2 ligand AGN-PC-03PQDX family 5 1
Histone deacetylase 1 and Histone deacetylase 2 inhibitor Sure... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN4856064 f... 1 0
Major prion protein and Microtubule-associated protein tau inh... 2 10
Aldo-keto reductase family 1 member C3 and Aldo-keto reductase... 2 1
Beta-lactamase and Microtubule-associated protein tau inhibito... 1 1
N-(4-acetamidophenyl)-2-(2,2-dimethyl-3,4-dihydrochromen-6-yl)... 1 0
4-(4-methoxyphenyl)-2,4,5,10-tetrahydro-1H-pyrrolo[3,4-c][1,5]... 4 0
Putative NP ZINC09660203 Family 15 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00267331 DNC010773 Investigative Drug N-(4-amino-3'-methoxybiphenyl-3-yl)benzamide
CFAMM00267324 DNC007880 Investigative Drug N-(2-aminophenyl)-4-(chroman-3-ylmethyl)benzamide
CFAMM00267330 DNC010778 Investigative Drug N-(4-amino-4'-methoxybiphenyl-3-yl)benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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