CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2390
Family Name Delta-type opioid receptor and Mu-type opioid receptor Ligand 6-(2-phenethylisoindolin-5-yloxy)nicotinamide Family
No. of Seeds 8 No. of Other Members 57
Family Centroid CFAMM00267400 Functional Category Investigative Drug with Natural Product
Superfamily Delta-type opioid receptor and Mu-type opioid receptor Ligand 6-(2-phenethylisoindolin-5-yloxy)nicotinamide Superfamily
Class Class 2449

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Mepyramine Family 5 65
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Cannabinoid receptor 1 Ligand Taranabant Family 20 30
Histamine H3 receptor Ligand GSK239512 Family 2 65
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Smoothened homolog Inhibitor LDE225 Family 3 76
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Cytochrome P450 3A4 Inhibitor 3-(5-((methylthio)methyl)furan-2... 4 14
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Renin Inhibitor CP-305202 Family 9 30
Beta-ketoacyl-acyl carrier protein synthase III Inhibitor 2-[3... 1 2
Reverse transcriptase/RNaseH inhibitor AC1LALKM family 2 19
Neutrophil elastase inhibitor phenyl N-[(2S)-1-[(2S)-2-[[(3S)-... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [4... 1 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Lanosterol synthase inhibitor (4-bromophenyl)-[6-[6-[methyl(pr... 1 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 5 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 2
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 1 0
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Somatostatin receptor type 5 ligand AGN-PC-088VSK family 2 3
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-[3-cy... 2 5
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
Sodium channel protein type 10 subunit alpha and Sodium channe... 1 1
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Vascular endothelial growth factor receptor 2 ligand AC1LMMCZ ... 1 0
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Cytochrome P450 2C19 and Inositol monophosphatase 1 inhibitor ... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Histamine H3 receptor ligand SureCN2784306 family 5 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 1 14
Histamine H3 receptor ligand 3-[4-[3-[(2R)-2-methylpyrrolidin-... 1 5
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 11
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 10 15
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 7
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 1 13
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 2
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
Growth hormone secretagogue receptor type 1 and Potassium volt... 2 0
Beta-1 adrenergic receptor ligand N-[2-[[(2S)-3-(2-cyanophenox... 2 1
Beta-3 adrenergic receptor ligand 6-[4-[2-[[(2S)-3-[(3,3-dimet... 6 7
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Histamine H3 receptor ligand 6-[[2-[2-[(2R)-2-methylpyrrolidin... 2 0
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 1 1
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Fatty-acid amide hydrolase 1 inhibitor [3-(3-carbamoylpyrrol-1... 4 6
G-protein coupled bile acid receptor 1 ligand (4-cyclopropyl-2... 10 13
G-protein coupled bile acid receptor 1 ligand (4-cyclopropyl-2... 2 1
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
Motilin receptor ligand SureCN2768193 family 2 1
Motilin receptor ligand SureCN2765637 family 1 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Prothrombin and Coagulation factor X inhibitor N-[3-[(3-fluoro... 1 8
Transient receptor potential cation channel subfamily V member... 6 1
Glutamate receptor ionotropic, NMDA 2B ligand SureCN5532501 fa... 1 0
Platelet-activating factor receptor ligand N,N-dimethyl-6-phen... 12 18
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 15
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
CGMP-dependent protein kinase inhibitor AGN-PC-075IHL family 2 8
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
72 kDa type IV collagenase and Aminopeptidase N inhibitor ly52... 1 0
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 6 1
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 5 1
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 3
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 3
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 1 0
Sodium channel protein type 9 subunit alpha and Sodium channel... 1 1
Dual specificity mitogen-activated protein kinase kinase 1 inh... 1 2
Tyrosine-protein kinase JAK3 and Activated CDC42 kinase 1 inhi... 4 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Reverse transcriptase/RNaseH inhibitor 3Am-6Et-7,9-diMe-PBOA-5... 4 1
Reverse transcriptase/RNaseH inhibitor 7CN-6Et-9Me-PBOA-5one f... 4 1
Coagulation factor X inhibitor 3-Oxybenzamide 15 family 1 1
Coagulation factor X and Cationic trypsin inhibitor 1qb6 family 4 15
Coagulation factor X and Cationic trypsin inhibitor SureCN6578... 1 3
Neutrophil elastase inhibitor SureCN8210283 family 2 2
Thromboxane-A synthase and Platelet-activating factor receptor... 1 6
Fatty-acid amide hydrolase 1 and Monoglyceride lipase inhibito... 1 3
Collagenase 3 inhibitor 4-[4-[2-[(3S)-3-hydroxy-1-azabicyclo[2... 1 0
Platelet-activating factor receptor ligand AGN-PC-001U4L family 2 0
NP N-(2-(3,4-dimethoxyphenyl)-4-oxo-4h-chromen-6-yl)nicotinami... 6 1
NP N-(2-(2-methoxyphenyl)-4-oxo-4h-chromen-6-yl)nicotinamide F... 9 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00267401 DNC007882 Investigative Drug 6-(2-benzylisoindolin-5-yloxy)nicotinamide
CFAMM00267400 DNC007881 Investigative Drug 6-(2-phenethylisoindolin-5-yloxy)nicotinamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

23964 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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