CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2407
Family Name 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine receptor 2C Ligand (e)-2-(4-fluorostyryl)-5-(phenylsulfinyl)pyridine Family
No. of Seeds 14 No. of Other Members 19
Family Centroid CFAMM00267500 Functional Category Investigative Drug
Superfamily Translocator protein and 5-hydroxytryptamine receptor 2A Binder Superfamily
Class Class 433

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
Prostaglandin G/H synthase 2 Inhibitor Etoricoxib Family 2 99
Solute carrier family 12 member 1 Inhibitor Torasemide Family 13 75
Histamine H1 receptor Ligand Pheniramine Family 10 380
5-hydroxytryptamine receptor 6 Ligand SB-742457 Family 9 66
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Rho-associated protein kinase 1 Inhibitor Rho-kinase Inhibitor... 6 39
E7820 family 9 56
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Platelet-derived growth factor receptor alpha and Platelet-der... 5 48
5-hydroxytryptamine receptor 6 Ligand E-6837 Family 22 44
Cytochrome P450 3A4 Inhibitor 3-(3-methylthiophen-2-yl)pyridin... 5 27
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 16
Mitogen-activated protein kinase 14 Inhibitor 4-(2-ethyl-4-m-t... 14 41
5-hydroxytryptamine receptor 6 Ligand 4-(4,6-dinitro-1h-indol-... 4 19
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
NF-kappa-B Inhibitor 9-chloro-5h-6-thia-4,5-diaza-chrysene 6,6... 3 27
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Hepatocyte growth factor receptor Ligand 1-(phenylsulfonyl)-1h... 1 5
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(n-o... 3 12
Prostaglandin G/H synthase 1 Inhibitor 1-(4-aminosulfonylpheny... 3 18
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Translocator protein Inhibitor 5-phenyl-6-thia-10b-aza-benzo[e... 1 2
Prostaglandin G/H synthase 2 Inhibitor 2-(4-(methylsulfonyl)ph... 7 33
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Prostaglandin G/H synthase 2 Inhibitor 1-(4-(methylsulfonyl)ph... 1 2
C-C chemokine receptor type 5 ligand AC1LAJBP family 2 6
Motilin receptor and Cytochrome P450 2D6 ligand 7-[[6-(4-chlor... 2 1
Protein kinase C theta type and Protein kinase C delta type in... 7 17
5-hydroxytryptamine receptor 6 ligand N-methyl-1-[(1R)-6-(1H-p... 3 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 14
5-hydroxytryptamine receptor 6 ligand AGN-PC-07ZA0N family 1 3
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 10 2
5-hydroxytryptamine receptor 6 ligand CHEMBL1950756 family 8 8
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 1 11
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 1
Cannabinoid receptor 2 ligand AGN-PC-09M5PW family 12 2
Cannabinoid receptor 2 ligand 1,1,1-trifluoro-N-[(2S)-6-(1-pyr... 2 1
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 8
Thyrotropin receptor and Huntingtin ligand CHEMBL1333081 family 1 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 5 10
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 2 4
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 3
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 3 7
5-hydroxytryptamine receptor 6 ligand AGN-PC-09QKIN family 2 9
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Histamine H1 receptor and Cytochrome P450 2D6 ligand N-methyl-... 1 0
Progesterone receptor and Mineralocorticoid receptor ligand AG... 6 1
Mineralocorticoid receptor and Glucocorticoid receptor ligand ... 5 0
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[2-(... 2 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 13 1
5-hydroxytryptamine receptor 2A ligand SureCN5215979 family 2 10
Sigma non-opioid intracellular receptor 1 ligand SureCN7434677... 1 0
5-hydroxytryptamine receptor 6 ligand SureCN3411879 family 10 3
5-hydroxytryptamine receptor 6 and Muscarinic acetylcholine re... 7 3
5-hydroxytryptamine receptor 6 ligand 1-(4-chlorophenyl)sulfon... 8 4
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 12 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
Prostaglandin D2 receptor 2 ligand 2-[5-fluoro-2-methyl-3-[(4-... 3 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 0
Presenilin-1 and Presenilin-2 inhibitor AGN-PC-050UV6 family 2 2
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 4 0
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 7 1
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-6-br... 5 1
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 2 0
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 5 2
5-hydroxytryptamine receptor 6 ligand 5-[3-(2-aminoethyl)indol... 1 0
Prostaglandin G/H synthase 2 inhibitor 1-(3,4-difluorophenyl)-... 1 3
Orexin receptor type 2 and Orexin receptor type 1 ligand 2-(1-... 3 0
Glucocorticoid receptor ligand 1-[(4aS)-6-(4-tert-butylphenyl)... 27 3
Metabotropic glutamate receptor 5 ligand 3-methyl-1-(2-thiophe... 2 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 2
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 3 4
5-hydroxytryptamine receptor 7 ligand 6-[(2R)-2-[2-(4-methylpi... 1 0
Mitogen-activated protein kinase 14 inhibitor 303163-37-3 family 1 2
CGMP-dependent protein kinase inhibitor 2-[[4-[5-(4-fluorophen... 1 0
Carbonic anhydrase 2 and Carbonic anhydrase 5A, mitochondrial ... 3 3
5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 ligand ... 6 0
Cannabinoid receptor 2 ligand 1-(benzenesulfonyl)-N-quinolin-3... 2 2
Prostaglandin G/H synthase 2 inhibitor SureCN6345015 family 6 1
Carbonic anhydrase 2 inhibitor AGN-PC-07C00G family 1 1
Prostaglandin D2 receptor 2 ligand SureCN2516080 family 1 0
5-hydroxytryptamine receptor 6 ligand 2-[[(1Z)-1-[5-(benzenesu... 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 6 ligand 4-bromo-N-[3-[[(2S)-1-me... 4 0
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Metabotropic glutamate receptor 5 and Cytochrome P450 1A2 liga... 2 1
Voltage-dependent L-type calcium channel subunit alpha-1C and ... 2 1
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 1 0
5-hydroxytryptamine receptor 6 ligand AGN-PC-07CR3B family 2 0
G-protein coupled bile acid receptor 1 ligand N-[[2-chloro-4-(... 1 0
Cytochrome P450 3A4 inhibitor N-[2-fluoro-4-(4-fluorophenyl)ph... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00267530 CHEMBL395458 Bioactive 5-fluoro-2-[(E)-2-[5-(2-fluorophenyl)sulfonylpyridin-2-yl]ethenyl]benzonitrile
CFAMM00267505 CHEMBL240665 Bioactive SureCN3167994
CFAMM00267524 CHEMBL1081094 Bioactive SureCN4071513
CFAMM00267514 CHEMBL240454 Bioactive 2-[(E)-2-(4-fluorophenyl)ethenyl]-5-(2-fluorophenyl)sulfonylpyridine
CFAMM00267531 CHEMBL1162962 Bioactive 5-(benzenesulfonyl)-2-[(E)-2-(2,4-difluorophenyl)ethenyl]pyridine
CFAMM00267521 CHEMBL394435 Bioactive 2-[(E)-2-(4-fluorophenyl)ethenyl]-5-(3-fluorophenyl)sulfonylpyridine
CFAMM00267500 DNC007934 Investigative Drug (E)-2-(4-fluorostyryl)-5-(phenylsulfinyl)pyridine
CFAMM00267499 DNC007935 Investigative Drug (E)-2-(4-fluorostyryl)-5-(phenylsulfonyl)pyridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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