CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID241
Family Name Histamine H3 receptor and Histamine H4 receptor Ligand Clobenpropit Family
No. of Seeds 31 No. of Other Members 38
Family Centroid CFAMM00185464 Functional Category Investigative Drug with Natural Product
Superfamily Histamine H3 receptor and Histamine H4 receptor Ligand Clobenpropit Superfamily
Class Class 1486

Cousin Family NamesSeedsMembers
Cytochrome P450 3A4 Inhibitor Clotrimazole Family 16 145
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Benzodiazepine receptor Ligand Midazolam Family 5 160
14-alpha sterol demethylase Inhibitor Butoconazole Family 2 53
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Farnesyltransferase beta subunit, putative Inhibitor BMS214662... 11 65
Telomerase protein component 1 Inhibitor GRN163L Family 5 29
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
HCV NS4B protein Inhibitor Clemizole Family 2 43
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Tryptase Inhibitor Babim Family 12 90
Kappa-type opioid receptor Ligand Brl 52974 Family 2 27
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Histamine H3 receptor Ligand Proxyfan Family 12 32
Histamine H3 receptor Ligand SCH79687 Family 11 29
Adenosine receptor A3 Ligand 2,6-bis(4-chlorophenyl)-9h-purine... 4 12
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 22
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 5 7
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 2
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-aminobenzyl... 3 6
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Mitogen-activated protein kinase kinase kinase 8 and Stromelys... 6 53
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Cytochrome P450 11B1, mitochondrial Inhibitor 3-(1-benzyl-1h-i... 3 5
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor 1-(3,4-dich... 1 0
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... 25 10
Somatostatin receptor type 4 and Glucosylceramidase ligand MLS... 1 16
Bombesin receptor subtype-3 ligand (2R)-1-[4-[2-[5-(2,2-dimeth... 1 1
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
Histamine H3 receptor ligand SureCN7853275 family 2 5
Sterol O-acyltransferase 1 inhibitor 1-(2,4-difluorophenyl)-3-... 8 90
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 2 0
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 28 9
Alpha-1D adrenergic receptor ligand 5-[(3-bromothiophen-2-yl)m... 8 0
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 3A4 in... 6 10
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Adenosine receptor A1 and Adenosine receptor A2b ligand SureCN... 1 0
RAC-alpha serine/threonine-protein kinase inhibitor (2S)-3-ami... 2 0
Mitogen-activated protein kinase 14 inhibitor (E)-3-(2,6-dichl... 1 1
Aromatase inhibitor AGN-PC-075MV1 family 1 3
Histamine H3 receptor and Histamine H2 receptor ligand SureCN7... 3 20
Histamine H4 receptor ligand (2Z)-5-chloro-2-[(1-methylpiperid... 2 8
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Histamine H3 receptor and Histamine H2 receptor ligand SureCN7... 2 2
Alpha-1D adrenergic receptor ligand (E)-but-2-enedioic acid;5-... 8 1
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 3
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
Sodium- and chloride-dependent glycine transporter 1 and Sodiu... 4 8
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
Histamine H3 receptor ligand 1-[4-(1H-imidazol-5-ylmethyl)pipe... 1 2
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
S-methyl-5'-thioadenosine phosphorylase inhibitor 2-[[(4-amino... 5 0
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
Methionine aminopeptidase 2 inhibitor SureCN5373581 family 6 0
Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... 2 1
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 0
Mitogen-activated protein kinase 14 inhibitor 5-[2-(2,6-dichlo... 1 0
Macrophage colony-stimulating factor 1 receptor and Receptor-t... 2 0
Histamine H3 receptor ligand AGN-PC-074FK2 family 4 1
Tripeptidyl-peptidase 2 inhibitor (2S)-2-amino-1-[(2S)-5-chlor... 1 0
Serine/threonine-protein kinase B-raf inhibitor 1-[2-[[4-[2-cy... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 1
Mitogen-activated protein kinase 14 inhibitor SureCN828349 family 1 0
Histidinol dehydrogenase inhibitor (3S)-3-amino-1-(2,4-difluor... 5 0
Histidinol dehydrogenase inhibitor (3S)-3-amino-1-(3,4-dichlor... 2 1
Pteridine reductase, putative inhibitor 1-[(3,4-dichlorophenyl... 2 1
Sodium/hydrogen exchanger 1 inhibitor SureCN14276439 family 1 1
Cannabinoid receptor 1 ligand AGN-PC-07CPJ5 family 9 14
Histamine H3 receptor ligand 5-(3-bromophenyl)-2-[2-(1H-imidaz... 2 2
Acyl-CoA:cholesterol acyltransferase and Sterol O-acyltransfer... 3 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00185475 CHEMBL1923026 Bioactive 3-(1H-imidazol-5-yl)propyl N-cyclohexyl-N'-[(3,4-dichlorophenyl)methyl]carbamimidothioate;hydrobromide
CFAMM00185423 CHEMBL1202332 Bioactive 3-(1H-imidazol-5-yl)propyl N'-[(3,4-dichlorophenyl)methyl]carbamimidothioate;dihydrobromide
CFAMM00185439 CHEMBL213886 Bioactive N-[(4-chlorophenyl)methyl]-2-[(1S,2R)-2-(1H-imidazol-5-yl)cyclopropyl]ethanamine
CFAMM00185415 CHEMBL482142 Bioactive AGN-PC-00B9RK
CFAMM00185438 CHEMBL373010 Bioactive AGN-PC-075YWT
CFAMM00185466 CHEMBL553423 Bioactive 3-(1H-imidazol-5-yl)propyl N'-[(3,4-dichlorophenyl)methyl]carbamimidothioate
CFAMM00185458 CHEMBL203263 Bioactive N-[(4-chlorophenyl)methyl]-5-(1H-imidazol-5-yl)pentan-1-amine
CFAMM00185473 CHEMBL1097394 Bioactive N-[(4-chlorophenyl)methyl]-2-[(2S)-2-(1H-imidazol-5-yl)cyclopropyl]ethanamine
CFAMM00185421 CHEMBL1099064 Bioactive N-[(4-chlorophenyl)methyl]-2-[(2R)-2-(1H-imidazol-5-yl)cyclopropyl]ethanamine
CFAMM00185428 CHEMBL1632409 Bioactive Clobenprobit
CFAMM00185472 CHEMBL1097393 Bioactive (2R)-N-[(4-chlorophenyl)methyl]-2-[(1R,2S)-2-(1H-imidazol-5-yl)cyclopropyl]butan-1-amine
CFAMM00185420 CHEMBL482306 Bioactive (NZ)-N-[(4-chlorophenyl)-[2-[3-(dimethylamino)propylsulfanyl]-3-methylimidazol-4-yl]methylidene]hydroxylamine
CFAMM00185435 CHEMBL1202318 Bioactive 3-(1H-imidazol-5-yl)propyl N'-[(2-chlorophenyl)methyl]carbamimidothioate;dihydrobromide
CFAMM00185478 CHEMBL45027 Bioactive N-[(2-chlorophenyl)methyl]-4-(1H-imidazol-5-yl)piperidine-1-carbothioamide
CFAMM00185470 CHEMBL1628561 Bioactive [125I]IODOPHENPROPIT
CFAMM00185417 CHEMBL1923032 Bioactive 3-(1H-imidazol-5-yl)propyl N-butyl-N'-[(3,4-dichlorophenyl)methyl]carbamimidothioate;hydrobromide
CFAMM00185425 CHEMBL314614 Bioactive 5-(4-chlorophenyl)-2-[2-(1H-imidazol-5-yl)ethylsulfanyl]-1H-imidazole
CFAMM00185431 CHEMBL1202321 Bioactive 3-(1H-imidazol-5-yl)propyl N'-[(4-iodophenyl)methyl]carbamimidothioate;dihydrobromide
CFAMM00185464 DNC000449 Investigative Drug Clobenpropit

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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