CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2414
Family Name Delta-type opioid receptor and Kappa-type opioid receptor Ligand H-cpa-gly-gly-phe-met-oh Family
No. of Seeds 3 No. of Other Members 21
Family Centroid CFAMM00267760 Functional Category Investigative Drug with Natural Product
Superfamily Genome polyprotein and Delta-type opioid receptor Binder Superfamily
Class Class 2006

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor Ligand Felypressin Family 12 820
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Penicillin binding protein inhibitor β-lactam aminopenicillin ... 12 359
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diet... 29 276
Tumor necrosis factor Inhibitor Thalidomide Family 3 50
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
ATP-sensitive inward rectifier potassium channel 10 Ligand Ace... 2 64
DNA Binder Procarbazine Family 8 358
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Angiotensin-converting enzyme and Neprilysin Inhibitor M100,24... 18 60
Cathepsin K Inhibitor Odanacatib Family 33 84
Iofolastat I-124 family 6 33
Bavisant family 9 65
Ezatiostat family 1 4
Neuropeptide Y receptor type 1 Ligand BIBO3304 Family 4 69
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
72 kDa type IV collagenase Inhibitor Batimastat Family 6 52
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Neutrophil elastase Inhibitor FK-706 Family 8 85
Neprilysin Inhibitor Thiorphan Family 41 68
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 18
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Neuromedin-K receptor Ligand Senktide Family 15 22
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Gamma-g... 2 1
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Thymidylate synthase Inhibitor Sp-876 Family 7 117
Penicillin-binding protein 1B Inhibitor N-benzoyl-d-alanine Fa... 1 40
Carbonic anhydrase 2 Inhibitor N-benzyl-4-sulfamoyl-benzamide ... 12 44
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Integrin alpha-V and Integrin beta-3 Inhibitor Cyclo-[-arg-gly... 5 38
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Integrin beta-3 Inhibitor Sibrafiban Family 4 6
Integrin beta-3 Inhibitor L-709780 Family 9 10
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Integrin beta-3 Inhibitor DMP-728 Family 3 0
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Histone deacetylase 1 Inhibitor 8-(3-benzoyl-ureido)-octanoic ... 7 13
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(6... 1 12
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Trifunctional purine biosynthetic protein adenosine-3 Inhibito... 2 11
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
Beta-secretase 1 Inhibitor KMI-172 Family 3 0
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Thyroid hormone receptor beta Ligand 1-(4-hexylphenyl)-3-(prop... 2 1
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Delta-type opioid receptor Ligand H-cxp-ala-gly-phe-leu-oh Family 1 8
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Substance-P receptor Ligand [sar9,met(o2)11]-sp Family 34 9
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Integrin alpha-V Inhibitor C[rgdf-(3s)-carboxymorpholine] Family 10 2
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... 6 19
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-137546 Family 1 3
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-154957 Family 2 3
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Inhibit... 5 23
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Cathepsin S Inhibitor N-(1-oxobutan-2-yl)-3-(trifluoromethyl)b... 2 10
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-benza... 3 9
Endothelin-converting enzyme 1 Inhibitor PO3 2-leu-nal-o-3k Fa... 3 26
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 80
Protein farnesyltransferase subunit beta Inhibitor L-739750 Fa... 4 0
Genome polyprotein Inhibitor Acasp-glu-dif-glu-cha-cys Family 13 17
Genome polyprotein Inhibitor Acasp-glu-met-glu-cha-cys Family 3 6
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Pol polyprotein inhibitor penicillin deriv. 49 family 3 19
Substance-P receptor ligand AGN-PC-00FJ8P family 6 10
Angiotensin-converting enzyme inhibitor (S)-1-((S)-5-benzamido... 5 2
Pol polyprotein inhibitor penicillin deriv. 38 family 1 1
Pol polyprotein inhibitor penicillin deriv. 34 family 3 18
Substance-K receptor ligand 4-(4-methylphenyl)-N-[1-[[(2S)-5-[... 6 0
C-C chemokine receptor type 2 ligand SureCN2988733 family 14 17
72 kDa type IV collagenase and Matrilysin inhibitor (2S,3R)-N-... 1 0
Angiotensin-converting enzyme inhibitor AGN-PC-074Y3I family 5 0
Neprilysin and Aminopeptidase N inhibitor (2S)-2-[[(2S)-2-[[[a... 13 1
Kappa-type opioid receptor ligand 6-[2-oxo-2-[(2S)-2-(pyrrolid... 6 4
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7285564... 1 2
Neprilysin inhibitor SureCN489232 family 3 9
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 2
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 1
Stromelysin-1 inhibitor 6-(4'-FLUORO-BIPHENYL-4-YL)-4-(3-METHY... 3 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-cycl... 1 6
Caspase-1 inhibitor AGN-PC-075AEI family 3 0
Dipeptidyl peptidase 4 inhibitor (3S)-4-[(3R)-3-amino-4-(2,4,5... 1 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor 2-[2-[... 10 5
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Cathepsin K and Cathepsin L1 inhibitor N-[1-(cyanomethylcarbam... 2 0
Melanin-concentrating hormone receptor 1 and Cytochrome P450 2... 3 4
Cathepsin S and Cathepsin K inhibitor N-[(2R)-1-[[cyano(methyl... 1 0
Prothrombin and Coagulation factor X inhibitor [(1R)-5-amino-1... 2 3
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 1 162
Glutamate carboxypeptidase 2 inhibitor (2S)-2-[[(1R)-1-carboxy... 8 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
Integrin beta-3 and Integrin alpha-IIb inhibitor AGN-PC-074AY6... 1 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2S,4R)... 5 8
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-2-(benze... 2 2
Caspase-1 inhibitor (3S)-3-[[(4S,7S)-7-[(2-fluorobenzoyl)amino... 4 0
Tryptase alpha/beta-1 and Tryptase delta inhibitor (2S,3R)-1-[... 8 0
Prothrombin inhibitor N-[7-amino-1-[2-(4-carbamoylphenyl)ethyl... 8 1
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN6949669... 12 3
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Prothrombin inhibitor methyl (3S)-3-[[(6S,8aS)-2-benzylsulfony... 5 1
Angiotensin-converting enzyme and Histone-lysine N-methyltrans... 1 19
Chymase and Chymotrypsinogen B inhibitor AGN-PC-075LTI family 2 3
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 1 2
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 5
Angiotensin-converting enzyme and Angiotensin-converting enzym... 1 0
Pol polyprotein inhibitor penicillin deriv. 43 family 2 1
Prothrombin inhibitor [(1R)-4-carbamimidoylsulfanyl-1-[[2-[met... 1 0
Carbonic anhydrase 2 inhibitor benzyl 2-[[2-[[(2S)-3-phenyl-2-... 2 9
Neutrophil elastase inhibitor 1-[(2S)-3-methyl-2-[(4-methylsul... 3 0
Cathepsin S and Cathepsin L1 inhibitor (Z,3S)-1-diazonio-3-[[2... 1 0
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2J2 inhib... 5 0
Receptor tyrosine-protein kinase erbB-2 and Disintegrin and me... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 6
Interstitial collagenase and 72 kDa type IV collagenase inhibi... 1 1
Retinal dehydrogenase 1 and 15-hydroxyprostaglandin dehydrogen... 2 0
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 1 3
Cathepsin L1 inhibitor (2R)-2-[[3-benzylsulfanyl-2-[[2-(4-phen... 1 0
Reverse transcriptase/RNaseH inhibitor (R)-(+)9B-(3-METHYL)PHE... 5 24
Integrin beta-1 and Integrin alpha-4 inhibitor (3S,6R,11R,14S)... 2 0
Caspase-1 inhibitor (3S)-4-oxo-3-[[(2S)-4-oxo-4-[(3-oxo-3-phen... 1 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (3... 2 0
Indoleamine 2,3-dioxygenase 1 inhibitor Quinone derivative, 13... 1 0
NP (z)-methyl 5-((3s,4s)-4-benzamido-3-hydroxydihydrothiophen-... 6 0
NP Methyl 5-((2s,3s,4r)-4-benzamido-3-chlorotetrahydrothiophen... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00267762 DNC007959 Investigative Drug H-Cpa-c[pen-Gly-Phe-pen]OH
CFAMM00267760 DNC007955 Investigative Drug H-Cpa-Gly-Gly-Phe-Met-OH
CFAMM00267758 DNC007953 Investigative Drug H-Cpa-Gly-Gly-Phe-Met-NH2

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26857 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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