CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2438
Family Name Serine/threonine-protein kinase Chk1 Inhibitor 6-(3-aminopropyl)benzo[h]isoquinolin-1(2h)-one Family
No. of Seeds 2 No. of Other Members 7
Family Centroid CFAMM00268207 Functional Category Investigative Drug
Superfamily Serine/threonine-protein kinase Chk1 Inhibitor 6-(3-aminopropyl)benzo[h]isoquinolin-1(2h)-one Superfamily
Class Class 2463

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
DNA Binder Procarbazine Family 8 358
Noradrenergic re-uptake Inhibitor Milnacipran Family 7 51
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Amonafide family 3 35
Bavisant family 9 65
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Aldose reductase Inhibitor Alrestatin Family 2 11
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Neutrophil elastase Inhibitor FK-706 Family 8 85
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Poly [ADP-ribose] polymerase 1 Inhibitor 3,4-dihydro-5-methyl-... 3 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Histone deacetylase 1 Inhibitor 8-(3-benzoyl-ureido)-octanoic ... 7 13
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(6... 1 12
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Tic... 11 31
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Poly [ADP-ribose] polymerase 1 Inhibitor 5-aminoisoquinolin-1(... 2 8
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Inhibit... 5 23
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Cathepsin S Inhibitor N-(1-oxobutan-2-yl)-3-(trifluoromethyl)b... 2 10
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Arachidonate 5-lipoxygenase Inhibitor Phenanthrene-3-carboxyli... 7 4
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-benza... 3 9
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 80
Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... 8 13
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 3 10
Substance-P receptor ligand AGN-PC-00FJ8P family 6 10
Substance-K receptor ligand 4-(4-methylphenyl)-N-[1-[[(2S)-5-[... 6 0
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
C-C chemokine receptor type 5 ligand AC1L9USC family 3 2
Kappa-type opioid receptor ligand 6-[2-oxo-2-[(2S)-2-(pyrrolid... 6 4
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 3
Prelamin-A/C and Ras-related protein Rab-9A inhibitor CHEMBL15... 1 7
Neuromedin-K receptor ligand SureCN2477089 family 2 4
Prothrombin inhibitor AGN-PC-09QJ23 family 2 5
Metabotropic glutamate receptor 5 ligand SureCN504295 family 1 7
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Mitogen-activated protein kinase 14 and Cytochrome P450 2C9 in... 2 0
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Histamine H3 receptor and Potassium voltage-gated channel subf... 9 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 6 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN4300689 f... 1 7
Tryptase alpha/beta-1 and Trypsin-1 inhibitor AGN-PC-074JFM fa... 3 1
Substance-P receptor ligand SureCN8936495 family 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Muscarinic acetylcholine receptor M3 ligand N-[[4-fluoro-3-[3-... 3 0
Legumain-like protease inhibitor N-[(2R)-1-[[(2S)-1-[2-(2-amin... 6 7
Coagulation factor X and Coagulation factor VII inhibitor AGN-... 1 2
Amine oxidase [flavin-containing] A inhibitor 9,10-dichloro-N-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00268207 DNC008055 Investigative Drug 6-(3-aminopropyl)benzo[h]isoquinolin-1(2H)-one
CFAMM00268206 DNC008056 Investigative Drug 9-chlorobenzo[h]isoquinolin-1(2H)-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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