CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2452
Family Name Transient receptor potential cation channel subfamily V member 1 Ligand JNJ-17203212 Family
No. of Seeds 2 No. of Other Members 26
Family Centroid CFAMM00268387 Functional Category Investigative Drug
Superfamily Transient receptor potential cation channel subfamily V member 1 Ligand SB-705498 Superfamily
Class Class 672

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
SUR2-type K(ATP) channel Ligand Pinacidil Family 1 8
Transient receptor potential cation channel subfamily V member... 15 158
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 6 66
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Reverse transcriptase Inhibitor Dapivirine Family 5 72
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Histone deacetylase 1 Inhibitor Pyroxamide Family 4 13
Amg 423 family 7 47
GDC-0349 family 44 77
Dipeptidyl peptidase 4 Inhibitor Nvp-dpp728 Family 11 42
Class II cytokine receptor Ligand IL-10 Family 7 45
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Carbonic anhydrase 2 Inhibitor Cyanamide Family 2 32
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 2-(4-... 8 25
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Macrophage migration inhibitory factor Inhibitor 1-(2-chloroph... 2 22
Reverse transcriptase Inhibitor PT-102 Family 8 12
D(2) dopamine receptor Ligand PD-135146 Family 5 11
Reverse transcriptase Inhibitor PT-109 Family 6 7
Prothrombin inhibitor SureCN5855286 family 15 8
Prothrombin inhibitor SureCN7371121 family 13 3
Prothrombin inhibitor SureCN5854779 family 4 9
Prothrombin inhibitor SureCN5856722 family 3 16
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Bloom syndrome protein inhibitor SR 57227A family 2 12
G1/S-specific cyclin-D1 and G1/S-specific cyclin-D3 inhibitor ... 6 3
Prothrombin and Trypsin-1 inhibitor SureCN12636557 family 9 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Toll-like receptor 7 ligand 6-amino-2-(butylamino)-9-[[4-(dime... 5 4
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Histamine H4 receptor ligand 4-[(3R)-3-(methylamino)pyrrolidin... 7 6
Metabotropic glutamate receptor 5 ligand SureCN3866791 family 2 10
Toll-like receptor 7 ligand 4-amino-1-[[6-[(2S)-2-(pyrrolidin-... 4 0
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Acetylcholinesterase and Cholinesterase inhibitor 2-amino-6-[3... 1 4
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 3
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-pyridin-2-ylpip... 4 4
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 7 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
Prothrombin inhibitor AGN-PC-073GVF family 12 1
Farnesyl pyrophosphate synthase inhibitor AC1NQOV1 family 2 1
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 2 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 10 1
Receptor-type tyrosine-protein kinase FLT3 ligand 4-[6-amino-5... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 0
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 3 6
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Transient receptor potential cation channel subfamily V member... 1 0
Transient receptor potential cation channel subfamily V member... 3 2
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 3 0
Microtubule-associated protein tau and Thyrotropin receptor li... 1 2
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 2
Coagulation factor X and Prothrombin inhibitor SureCN6578740 f... 1 0
Hormone-sensitive lipase inhibitor AGN-PC-074W3L family 1 2
Nonstructural protein 1 and Cruzipain inhibitor CHEMBL1331578 ... 1 2
Mitogen-activated protein kinase 1 and Cytochrome P450 2C19 in... 2 0
Interstitial collagenase inhibitor AGN-PC-03RA86 family 1 0
(5Z)-2-methoxy-11-methyl-3,4-dihydropyrido[1,2-a][1,3]diazocin... 1 0
4,5-dimethyl-5,6-dihydro-4H-pyrrolo[3,2,1-de]pteridin-2-ol NP ... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00268387 DNC008107 Investigative Drug JNJ-17203212
CFAMM00268394 DNC012075 Investigative Drug 4-Pyridin-2-yl-piperazine-1-carboxylic acid amide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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