CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2453
Family Name Metabotropic glutamate receptor 1 Ligand JNJ-16259685 Family
No. of Seeds 3 No. of Other Members 20
Family Centroid CFAMM00268407 Functional Category Investigative Drug with Natural Product
Superfamily Poly [ADP-ribose] polymerase 1 and Metabotropic glutamate receptor 1 Binder Superfamily
Class Class 656

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Leukotriene B4 receptor 1 Ligand SB-201993 Family 5 13
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
DNA topoisomerase 2-beta Inhibitor 4-(furan-3-yl)-2,6-di(thiop... 2 0
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 11
Adenosine receptor A3 and Adenosine receptor A1 ligand propyl ... 6 63
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 18
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
Leukotriene B4 receptor 1 ligand SureCN8987110 family 8 20
Leukotriene B4 receptor 1 ligand SureCN8987047 family 4 3
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Metabotropic glutamate receptor 1 ligand [11C]JNJ-16567083 family 9 2
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Cysteinyl leukotriene receptor 1 and Peripheral myelin protein... 1 1
NS5B protein inhibitor AC1O5AET family 3 1
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 12 3
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Prostaglandin E synthase inhibitor 3-[4-(3-cyanopropoxy)-3-met... 2 4
3-oxo-5-alpha-steroid 4-dehydrogenase 2 inhibitor 4-(benzyloxy... 1 10
Disintegrin and metalloproteinase domain-containing protein 17... 5 4
C-C chemokine receptor type 5 ligand N-methyl-4-[6-methyl-5-[[... 2 2
Disintegrin and metalloproteinase domain-containing protein 17... 8 0
Prothrombin and Trypsin-1 inhibitor AGN-PC-074I4I family 3 1
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... 2 6
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
Nuclear receptor ROR-gamma and Ras-related protein Rab-9A liga... 1 0
DNA polymerase beta and Microtubule-associated protein tau inh... 1 1
Potassium-transporting ATPase alpha chain 1 and Potassium-tran... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00268411 CHEMBL369459 Bioactive Ethanone, 1-(3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-2-phenyl-
CFAMM00268407 DNC008108 Investigative Drug JNJ-16259685
CFAMM00268418 DNC013474 Investigative Drug 2-benzyloxy-7,8-dihydro-6H-quinolin-5-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48705 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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