CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2456
Family Name Transient receptor potential cation channel subfamily V member 1 Ligand N-(4-iodophenyl)-4-(trifluoromethyl)benzamide Family
No. of Seeds 1 No. of Other Members 5
Family Centroid CFAMM00268480 Functional Category Investigative Drug
Superfamily Metabotropic glutamate receptor 5 and Transient receptor potential cation channel subfamily V member 1 Binder Superfamily
Class Class 2123

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Voltage-gated sodium channel Ligand Oxcarbazepine Family 1 4
Histone deacetylase 1 Inhibitor Vorinostat Family 26 138
Serum albumin Inhibitor Ebselen Family 3 62
Dual specificity mitogen-activated protein kinase kinase Inhib... 5 13
Motilin receptor Ligand GSK962040 Family 30 457
Poly [ADP-ribose] polymerase 1 Inhibitor BSI-201 Family 3 16
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Dual specificity mitogen-activated protein kinase kinase Inhib... 8 4
K-604 family 4 71
Pan-DAC Inhibitor AR-42 Family 21 153
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
C-C chemokine receptor type 5 Ligand Tak-220 Family 8 56
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Mitogen-activated protein kinase kinase kinase 1 and Mitogen-a... 1 0
Fumarate reductase flavoprotein subunit Inhibitor 2-heptyl-4-h... 3 16
Liver carboxylesterase 1 Inhibitor 1-methyl-1h-indole-2,3-dion... 10 35
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor N-(4-s... 12 92
Epidermal growth factor receptor Ligand 5,6-bis-p-tolylamino-i... 2 2
Potassium voltage-gated channel subfamily A member 5 Ligand N-... 8 32
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Integrin beta-3 Inhibitor L-750034 Family 7 38
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Transient receptor potential cation channel subfamily V member... 6 33
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 1 9
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Oxysterols receptor LXR-alpha Ligand 2-(2-phenethylphenyl)isoi... 4 7
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor Benz... 3 12
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 12
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Metabotropic glutamate receptor 5 Ligand N-(3-acetamidophenyl)... 4 20
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
Histone deacetylase 2 Inhibitor N-(4-amino-4'-bromobiphenyl-3-... 1 1
MO15-related protein kinase Pfmrk Inhibitor 2-chloro-n-(o-toly... 6 28
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 9 7
D(2) dopamine receptor Ligand PD-168077 Family 6 5
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(3-cyanophe... 7 5
Dihydroorotate dehydrogenase Inhibitor N-(4-bromo-2-methylphen... 1 3
Myeloperoxidase Inhibitor 4-aminobenzoic Acid Hydrazide Family 1 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
D(4) dopamine receptor ligand AGN-PC-074VC9 family 2 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 7 5
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 5
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 3
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
D(2) dopamine receptor and D(3) dopamine receptor ligand 1,1-d... 2 7
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 6
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Kappa-type opioid receptor ligand N-methyl-N-[(1S)-2-pyrrolidi... 3 17
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
Transient receptor potential cation channel subfamily V member... 1 1
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19
Urokinase plasminogen activator surface receptor ligand 5,12-d... 1 0
Histone deacetylase 1 inhibitor SureCN3642893 family 10 23
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
Chitin synthase 1 inhibitor AC1O53V7 family 9 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 2
Histone deacetylase 6 and Histone deacetylase 2 inhibitor 4-[[... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
Acetylcholinesterase inhibitor tmtfa family 1 2
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
Receptor-type tyrosine-protein kinase FLT3 ligand SureCN329077... 2 2
Histone deacetylase 1 inhibitor 2-[4-[(2-aminophenyl)carbamoyl... 1 1
Serine/threonine-protein kinase Chk1 inhibitor 6-oxo-9-(2-oxo-... 1 0
Proteinase-activated receptor 1 ligand 2-bromo-N-[3-(butanoyla... 4 0
G protein-activated inward rectifier potassium channel 4 and G... 1 0
Lysophosphatidic acid receptor 3 and Microtubule-associated pr... 1 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN4854179 f... 1 0
3-prop-2-enyl-1H-quinolin-4-one NP 6-amino-2-methylquinolin-4-... 5 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00268480 DNC008116 Investigative Drug N-(4-iodophenyl)-4-(trifluoromethyl)benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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