CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2458
Family Name Beta-secretase 1 Inhibitor GSK-188909 Family
No. of Seeds 16 No. of Other Members 11
Family Centroid CFAMM00268608 Functional Category Investigative Drug
Superfamily Beta-secretase 1 Inhibitor GSK-188909 Superfamily
Class Class 2399

Cousin Family NamesSeedsMembers
Kappa-type opioid receptor Ligand Asimadoline Family 14 54
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Beta-secretase 1 Inhibitor KMI-538 Family 4 20
Beta-secretase 1 and Cathepsin D inhibitor 3ixk family 2 9
Beta-secretase 1 and Cathepsin D inhibitor 3ixj family 10 21
Beta-secretase 1 inhibitor SureCN8292705 family 7 6
Beta-secretase 1 inhibitor SureCN8293614 family 2 0
Beta-secretase 1 inhibitor N-[(1S,2S)-1-[(2R)-4-benzylsulfonyl... 2 0
Beta-secretase 1 and Cathepsin D inhibitor 3-(4-chloro-N-methy... 1 0
Beta-secretase 1 and Beta-secretase 2 inhibitor SureCN5224847 ... 3 24
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 6 6
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 0
Pol polyprotein inhibitor 183860-48-2 family 5 1
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 6 5
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 5 2
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 1
Pol polyprotein inhibitor 3-[(4R,5R,6R)-4-benzyl-3-(3-carbamoy... 3 1
Delta-type opioid receptor and Potassium voltage-gated channel... 3 2
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
C-C chemokine receptor type 2 ligand N-[2-[[(2S,3S)-1-[(2,4-di... 13 8
C-C chemokine receptor type 2 ligand N-[3-amino-5-(trifluorome... 4 1
Cathepsin D and Cathepsin E inhibitor methyl (2S)-1-[(2R)-2-[[... 1 0
C-C chemokine receptor type 3 ligand 1-(3-acetylphenyl)-3-[3-[... 9 1
P2X purinoceptor 7 inhibitor 2-[3-fluoro-4-(trifluoromethyl)ph... 3 0
Beta-secretase 1 inhibitor CHEMBL400438 family 5 16
Beta-secretase 1 inhibitor 1-N-[(1R,2S)-1-[(2R,4S)-4-butoxypip... 5 1
Beta-secretase 1 and Beta-secretase 2 inhibitor 3-(1,1-dioxoth... 6 2
Beta-secretase 1 and Cathepsin B inhibitor 3-chloro-N-[(2S)-1-... 2 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 7 12
Beta-secretase 1 inhibitor N-[(2S,3R)-1-(3,5-difluorophenyl)-3... 5 5
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 2 0
Pol polyprotein inhibitor 3-amino-N-[(2S,3S,4R,5S)-5-[(3-amino... 2 1
Pol polyprotein inhibitor AC1LA3BI family 4 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00268601 CHEMBL1097344 Bioactive 3-N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R)-4-(3-methylphenyl)sulfonylpiperazin-2-yl]propan-2-yl]-5-(1,1-dioxothiazinan-2-yl)-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
CFAMM00268594 CHEMBL264321 Bioactive hydroxy ethylamine (HEA), 8
CFAMM00268607 CHEMBL1165545 Bioactive 3-(1,1-dioxothiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[3-(trifluoromethyl)anilino]butan-2-yl]benzamide
CFAMM00268600 CHEMBL401473 Bioactive 3-(1,1-dioxothiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]benzamide
CFAMM00268599 CHEMBL504438 Bioactive 3-(1,1-dioxothiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]benzamide;formic acid
CFAMM00268605 CHEMBL445734 Bioactive SureCN5221449
CFAMM00268598 CHEMBL591428 Bioactive 3-N-[(2S,3S)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-1-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-(methanesulfonamido)benzene-1,3-dicarboxamide
CFAMM00268603 CHEMBL1097346 Bioactive N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R)-4-(3-methylphenyl)sulfonylpiperazin-2-yl]propan-2-yl]-3-(ethylamino)-5-[methyl(methylsulfonyl)amino]benzamide
CFAMM00268602 CHEMBL1097345 Bioactive N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R)-4-(3-methylphenyl)sulfonylpiperazin-2-yl]propan-2-yl]-3-(1,1-dioxothiazinan-2-yl)-5-(ethylamino)benzamide
CFAMM00268608 DNC008119 Investigative Drug GSK-188909

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27529 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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