CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2460
Family Name Adenosine receptor A2b Ligand CVT-7124 Family
No. of Seeds 14 No. of Other Members 64
Family Centroid CFAMM00268700 Functional Category Investigative Drug
Superfamily Adenosine receptor A2b Ligand CVT-7124 Superfamily
Class Class 1286

Cousin Family NamesSeedsMembers
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Inhibitor Arof... 3 196
Translocator protein Inhibitor Emapunil Family 7 89
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Dipeptidyl peptidase 4 Inhibitor SSR-162369 Family 8 27
GP-531 family 1 33
Adenosine receptor A1 and Adenosine receptor A2a Ligand 8-phen... 12 213
Adenosine receptor A1 and Adenosine receptor A2b Ligand PSB-11... 34 26
Herpes simplex virus type 1 thymidine kinase Inhibitor 9-(4-hy... 2 13
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Coagulation factor IX and Coagulation factor X Inhibitor Razax... 22 34
Adenosine receptor A2b Ligand CVT-6694 Family 1 22
Adenosine receptor A2a Ligand (e,e)-8-(4-phenylbutadien-1-yl)c... 11 43
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SCH-577... 9 29
Herpes simplex virus type 1 thymidine kinase Inhibitor N2-(3-t... 1 2
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Prothrombin inhibitor SureCN5856722 family 3 16
Adenosine receptor A1 ligand SureCN10614388 family 5 1
Adenosine receptor A1 ligand 8-(2-amino-4-nitrophenyl)-1,3-dim... 1 0
Adenosine receptor A1 and Adenosine receptor A2b ligand 3-meth... 7 19
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-[4-[... 12 15
Dipeptidyl peptidase 4 inhibitor Xanthine Analogue 4 family 1 4
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Histamine H4 receptor ligand SureCN602132 family 1 8
Dipeptidyl peptidase 8 and Dipeptidyl peptidase 4 inhibitor Su... 5 13
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Tyrosine-protein kinase JAK2 inhibitor N-[2-(3-chlorophenyl)-5... 2 11
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Adenosine receptor A3 and Adenosine receptor A1 ligand (8R)-8-... 4 0
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 2 2
Adenosine receptor A3 and Adenosine receptor A1 ligand (2Z)-2-... 5 3
Metabotropic glutamate receptor 5 ligand SureCN3866791 family 2 10
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 9 0
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Adenosine receptor A2b ligand (8Z)-8-(6-oxopyridin-3-ylidene)-... 1 0
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 3 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
DNA gyrase subunit B inhibitor 5-[2-(ethylcarbamoyl)-4-[3-(tri... 2 4
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 16 5
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 3 0
P2X purinoceptor 7 inhibitor SureCN9931311 family 2 0
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-chloro... 2 0
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 0
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 12 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Cathepsin K inhibitor SureCN4138062 family 7 0
Adenosine receptor A2b ligand N-(4-chlorophenyl)-2-[(5Z)-5-(2,... 1 2
Adenosine receptor A1 ligand 3-(4-Aminophenethyl)-8-(3-noradam... 1 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Acyl-CoA desaturase 1 inhibitor AGN-PC-09QJVI family 2 0
Adenosine receptor A2b and Adenosine receptor A1 ligand N-[(3Z... 2 2
Adenosine receptor A2b ligand N-[(3Z)-3-(2,6-dioxo-1,3-dipropy... 1 0
Adenosine receptor A2b and Adenosine receptor A1 ligand 8-[1-[... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00268706 CHEMBL208824 Bioactive SureCN1945187
CFAMM00268660 CHEMBL259300 Bioactive 1-(cyclopropylmethyl)-8-[1-[(3-fluorophenyl)methyl]pyrazol-4-yl]-3-methyl-7H-purine-2,6-dione
CFAMM00268686 CHEMBL259342 Bioactive 1-ethyl-3-methyl-8-[1-[[3-(trifluoromethyl)phenyl]methyl]pyrazol-4-yl]-7H-purine-2,6-dione
CFAMM00268652 CHEMBL253252 Bioactive SureCN1944654
CFAMM00268679 CHEMBL404168 Bioactive SureCN242942
CFAMM00268684 CHEMBL404349 Bioactive 1-(cyclopropylmethyl)-8-[1-[[3-(trifluoromethyl)phenyl]methyl]pyrazol-4-yl]-3,7-dihydropurine-2,6-dione
CFAMM00268712 CHEMBL380284 Bioactive SureCN1946012
CFAMM00268696 CHEMBL200779 Bioactive 8-[1-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
CFAMM00268664 DNC008425 Investigative Drug CVT-6883
CFAMM00268700 DNC008124 Investigative Drug CVT-7124

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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