CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2462
Family Name Mitogen-activated protein kinase 11 and Mitogen-activated protein kinase 14 Inhibitor BMS-640994 Family
No. of Seeds 10 No. of Other Members 31
Family Centroid CFAMM00268757 Functional Category Investigative Drug with Natural Product
Superfamily Mitogen-activated protein kinase 11 and Mitogen-activated protein kinase 14 Inhibitor BMS-640994 Superfamily
Class Class 689

Cousin Family NamesSeedsMembers
Cathepsin B and Cathepsin K Inhibitor L-006235-1 Family 19 75
Arachidonate 5-lipoxygenase Inhibitor N-(thiazol-2-yl)benzamid... 3 53
Arachidonate 5-lipoxygenase Inhibitor 2-phenyl-n-(thiazol-2-yl... 3 27
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Acyl-CoA desaturase and Acyl-CoA desaturase 1 Inhibitor MF-152... 2 1
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 1 1
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 15 8
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Aurora kinase A and Aurora kinase B inhibitor 4-amino-N-[4-(th... 1 1
D(4) dopamine receptor ligand Benzamide, 3-methyl-N-[[4-(2-thi... 2 1
MAP kinase-activated protein kinase 2 inhibitor 2-[(4,4-dimeth... 11 11
Mitogen-activated protein kinase 14 inhibitor AGN-PC-006UPD fa... 1 1
Tyrosine-protein kinase Lck inhibitor AGN-PC-03HL8Q family 4 0
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-00A4QJ family 12 6
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-04XL74 family 1 0
Proto-oncogene tyrosine-protein kinase LCK and Tyrosine-protei... 3 9
Niemann-Pick C1 protein and Survival motor neuron protein inhi... 1 2
Coagulation factor X inhibitor AGN-PC-09QNAS family 2 1
Methionine aminopeptidase and Methionine aminopeptidase 1 inhi... 3 7
Mitogen-activated protein kinase 14 inhibitor N-[4-methyl-3-[6... 1 1
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-03LEDF family 3 4
Cyclin-dependent kinase 5 and G1/S-specific cyclin-E1 inhibito... 2 1
Glucokinase inhibitor (2S)-3-cyclohexyl-2-(7-ethylsulfonyl-4-o... 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00268772 CHEMBL257996 Bioactive N-[2-methyl-5-(methylcarbamoyl)phenyl]-2-(propylamino)-1,3-thiazole-5-carboxamide
CFAMM00268771 CHEMBL403200 Bioactive AGN-PC-008PCN
CFAMM00268779 CHEMBL255482 Bioactive AGN-PC-00A1GN
CFAMM00268770 CHEMBL257994 Bioactive AGN-PC-009SRW
CFAMM00268793 CHEMBL258203 Bioactive 2-[[(2S)-butan-2-yl]amino]-N-[2-methyl-5-(methylcarbamoyl)phenyl]-1,3-thiazole-5-carboxamide
CFAMM00268755 CHEMBL255698 Bioactive AGN-PC-0094XN
CFAMM00268769 CHEMBL257995 Bioactive N-(5-carbamoyl-2-methylphenyl)-2-(propan-2-ylamino)-1,3-thiazole-5-carboxamide
CFAMM00268791 CHEMBL258201 Bioactive N-[2-methyl-5-(methylcarbamoyl)phenyl]-2-(propan-2-ylamino)-1,3-thiazole-5-carboxamide
CFAMM00268789 CHEMBL258223 Bioactive N-[2-methyl-5-[(2-methylpyrazol-3-yl)carbamoyl]phenyl]-2-(propan-2-ylamino)-1,3-thiazole-5-carboxamide
CFAMM00268757 DNC008126 Investigative Drug BMS-640994

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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