CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2468
Family Name Nitric oxide synthase, inducible and Nitric oxide synthase, brain Inhibitor Ar-c102222 Family
No. of Seeds 4 No. of Other Members 6
Family Centroid CFAMM00268882 Functional Category Investigative Drug
Superfamily ARN-509 Superfamily
Class Class 295

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
HIV protease Inhibitor Saquinavir Family 64 428
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Histamine H1 receptor Ligand Triprolidine Family 19 316
26S proteasome Inhibitor Bortezomib Family 7 65
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Prothrombin Inhibitor Dabigatran Family 7 182
Transient receptor potential cation channel subfamily V member... 16 295
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Mitogen-activated protein kinase 12 Inhibitor VX-702 Family 3 49
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Substance-P receptor Ligand TAK-637 Family 18 63
Amg 423 family 7 47
Histone deacetylase Inhibitor JNJ-26481585 Family 2 5
ABC294640 family 5 75
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Tyrosine-protein kinase BTK Inhibitor CC-292 Family 6 10
JAK Inhibitor Momelotinib Family 33 83
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
XL-888 family 16 85
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Arachidonate 5-lipoxygenase Inhibitor Ici 207968 Family 3 7
Class II cytokine receptor Ligand IL-10 Family 7 45
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 6 Inhibi... 2 3
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-chlorophenyl)-5-... 2 8
Tubulin beta chain Inhibitor 2-(3-chloro-phenyl)-1h-[1,8]napht... 3 13
Tubulin beta chain Inhibitor 7-methyl-2-m-tolyl-1h-[1,8]naphth... 7 15
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Integrin beta-3 Inhibitor Elarofiban Family 28 45
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Alpha-1A adrenergic receptor Ligand L-771688 Family 8 14
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
M-phase inducer phosphatase 3 Inhibitor NSC-663284 Family 1 12
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Adenosine receptor A1 Ligand N-(4,6-diphenylpyrimidin-2-yl)ben... 4 8
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 4
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Tubulin beta chain Inhibitor 2-m-tolyl-1h-[1,8]naphthyridin-4-... 5 2
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Reverse transcriptase/RNaseH inhibitor AC1LAJTF family 6 5
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family 2 6
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
Transient receptor potential cation channel subfamily V member... 1 4
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 1 0
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Nicotinamide phosphoribosyltransferase inhibitor 4-[(7-chloro-... 6 4
Serine/threonine-protein kinase mTOR and RAC-alpha serine/thre... 3 3
Neuronal acetylcholine receptor subunit alpha-7 and Acetylchol... 2 3
Adenosine receptor A2a ligand SureCN14156209 family 3 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M45... 8 1
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 2 7
Gonadotropin-releasing hormone receptor ligand AGN-PC-075KV1 f... 4 1
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Reverse transcriptase/RNaseH inhibitor AC1MHDLR family 2 1
G1/S-specific cyclin-D1 and G1/S-specific cyclin-D3 inhibitor ... 6 3
Prelamin-A/C and Tyrosyl-DNA phosphodiesterase 1 inhibitor nif... 1 0
Reverse transcriptase/RNaseH inhibitor Dipyridodiazepinone der... 1 8
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-[[2-[6-m... 13 12
Coagulation factor X inhibitor AGN-PC-078Y4E family 4 6
Cellular tumor antigen p53 inhibitor CHEMBL1551403 family 1 0
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
Hepatocyte growth factor receptor and Insulin receptor ligand ... 4 15
Dipeptidyl peptidase 4 inhibitor SureCN3389584 family 2 2
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 9 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04SK7R family 3 3
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Coagulation factor X and Kallikrein-1 inhibitor SureCN890858 f... 5 6
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
Coagulation factor X inhibitor AGN-PC-078Y3A family 4 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SVV family 2 12
Histamine H3 receptor ligand SureCN1857507 family 1 4
Neuropeptide Y receptor type 5 ligand (5E)-5-[(4S,5S)-4-(4-flu... 18 3
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 3 5
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 13 3
Mitogen-activated protein kinase 9 and MAP kinase-activated pr... 1 0
Nicotinamide phosphoribosyltransferase inhibitor 4-[[(7-chloro... 1 1
Metabotropic glutamate receptor 5 ligand SureCN3866791 family 2 10
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 4 8
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
B1 bradykinin receptor ligand 6-(8-fluoro-4-methyl-1-oxophthal... 3 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Mitogen-activated protein kinase 14 inhibitor SureCN3305171 fa... 1 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Transient receptor potential cation channel subfamily V member... 2 1
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(2-amino-6... 13 0
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(4-chlorob... 6 0
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Delta-type opioid receptor and Potassium voltage-gated channel... 2 0
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 3 2
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 7 1
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 9 0
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
Aurora kinase B and Cyclin-dependent kinase 1 inhibitor 7-cycl... 3 16
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
Cell division cycle 7-related protein kinase and Protein DBF4 ... 1 5
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
5-hydroxytryptamine receptor 3A ligand 3-methyl-N-[7-[[3-methy... 2 0
Heat shock protein HSP 90-beta inhibitor 1-(2-amino-4-methylqu... 1 2
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Dipeptidyl peptidase 4 inhibitor 2-[[2-[(3R)-3-aminopiperidin-... 1 0
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Epidermal growth factor receptor ligand N-[3-[3-methyl-7-[4-(4... 2 1
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 1 0
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 3 1
B1 bradykinin receptor ligand methyl 2-fluoro-6-[3-fluoro-4-[[... 22 11
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Poly [ADP-ribose] polymerase 1 inhibitor 8-[[4-fluoro-3-(4-pyr... 5 2
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-isoquinolin-1-y... 3 2
Substance-P receptor ligand Netupitant family 5 2
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Smoothened homolog inhibitor 3-pyridin-3-yl-N-[1-[[6-[4-[(3-py... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 11 2
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 0
ALK tyrosine kinase receptor ligand N-[6-[[4-(2-hydroxypropan-... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 4 8
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
Tyrosine-protein kinase receptor TYRO3 and Mitogen-activated p... 3 7
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor 6-... 1 0
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 1 2
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 3 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Motilin receptor ligand SureCN2768052 family 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticoster... 2 0
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ... 10 0
Nicotinamide phosphoribosyltransferase inhibitor 4-[[7-bromo-3... 1 0
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 7 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
Epidermal growth factor receptor ligand N-[3-[2-(4-morpholin-4... 2 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 3 0
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 7
Macrophage colony-stimulating factor 1 receptor and Mast/stem ... 27 4
Coagulation factor X inhibitor 5-bromo-N-(5-chloropyridin-2-yl... 1 1
Coagulation factor X inhibitor AGN-PC-078Y0S family 7 1
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 1
Glutamate receptor 1 and Glutamate receptor 2 ligand cp-465022... 1 6
Integrin beta-3 and Integrin alpha-V inhibitor 2-[(2S)-4-methy... 2 0
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-00CD7W family 5 5
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[4-oxo-3-(4-p... 2 1
Coagulation factor X inhibitor N-[2-[(5-chloropyridin-2-yl)sul... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Epidermal growth factor receptor ligand (E)-1-[4-(3-bromoanili... 9 0
Cathepsin S and Cathepsin K inhibitor 2-cyano-N-[(2R)-1-phenyl... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 4
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
Macrophage colony-stimulating factor 1 receptor ligand N-[3-[(... 5 0
Adenosine receptor A1 and Adenosine receptor A3 ligand CHEMBL4... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 0
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 5 0
Transient receptor potential cation channel subfamily V member... 3 2
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Poly [ADP-ribose] polymerase 1 inhibitor Piperazine analogue, ... 4 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 1 0
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 2 2
Mitogen-activated protein kinase 14 inhibitor AGN-PC-077MAQ fa... 1 0
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 3
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Cannabinoid receptor 2 ligand AGN-PC-00SRU5 family 2 0
Metabotropic glutamate receptor 5 ligand 3-methyl-1-[2-[3-(tri... 3 1
Histone deacetylase 1 inhibitor SureCN4538615 family 2 2
C-C chemokine receptor type 3 ligand 4-[[2-(4-chlorophenyl)eth... 2 1
Glycogen synthase kinase-3 beta inhibitor SureCN13987027 family 1 0
Vesicular acetylcholine transporter and Sigma non-opioid intra... 2 0
Potassium voltage-gated channel subfamily KQT member 3 and Pot... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 2
3-[(3S)-2,5-dioxo-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]-N-pyr... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00268878 CHEMBL411044 Bioactive N-(5-fluoropyridin-2-yl)-2-[[4-(2-oxopyridin-1-yl)benzoyl]amino]benzamide
CFAMM00268875 CHEMBL1926905 Bioactive 6-cyano-2,4-dimethyl-N-[(3R)-3-[4-[N-[(4-methylpyridin-3-yl)methyl]anilino]piperidin-1-yl]butyl]pyridine-3-carboxamide
CFAMM00268881 CHEMBL88856 Bioactive 2-[3-[4-(2-cyanophenyl)piperazin-1-yl]propylamino]-N,N-dimethylpyridine-3-carboxamide
CFAMM00268882 DNC008172 Investigative Drug AR-C102222

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27433 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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