CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2469
Family Name NF-kappa-B Inhibitor 9-chloro-5h-6-thia-4,5-diaza-chrysene 6,6-dioxide Family
No. of Seeds 3 No. of Other Members 27
Family Centroid CFAMM00268906 Functional Category Investigative Drug
Superfamily NF-kappa-B and Coagulation factor X Binder Superfamily
Class Class 1575

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
5-hydroxytryptamine receptor 6 Ligand SB-742457 Family 9 66
Rho-associated protein kinase 1 Inhibitor Rho-kinase Inhibitor... 6 39
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
5-hydroxytryptamine receptor 6 Ligand E-6837 Family 22 44
5-hydroxytryptamine receptor 6 Ligand 4-(4,6-dinitro-1h-indol-... 4 19
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19
NF-kappa-B Inhibitor 5-bromo-n-(quinolin-8-yl)thiophene-2-sulf... 2 5
NF-kappa-B Inhibitor 2-nitro-n-(quinolin-8-yl)benzenesulfonami... 2 3
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Prostaglandin G/H synthase 2 Inhibitor 2-(4-(methylsulfonyl)ph... 7 33
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 10 2
5-hydroxytryptamine receptor 6 ligand AGN-PC-09QKIN family 2 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 13 1
5-hydroxytryptamine receptor 6 ligand SureCN3411879 family 10 3
5-hydroxytryptamine receptor 6 and Muscarinic acetylcholine re... 7 3
5-hydroxytryptamine receptor 6 ligand 1-(4-chlorophenyl)sulfon... 8 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 15 3
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 7 1
5-hydroxytryptamine receptor 6 ligand 9-(2-bromophenyl)sulfony... 2 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 7 liga... 3 11
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 5 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 2
5-hydroxytryptamine receptor 6 ligand 3,4-dichloro-N-[3-[[(2R)... 5 0
5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 ligand ... 6 0
Cannabinoid receptor 1 ligand N-[[(3R,6S)-1-(4-chlorophenyl)-6... 2 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 0
Oxysterols receptor LXR-beta ligand SureCN3491581 family 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00268888 CHEMBL1914710 Bioactive N-(2-chloro-5-quinolin-6-ylpyridin-3-yl)-4-fluorobenzenesulfonamide
CFAMM00268911 CHEMBL1914715 Bioactive N-(2-chloro-5-quinoxalin-6-ylpyridin-3-yl)-4-fluorobenzenesulfonamide
CFAMM00268906 DNC008175 Investigative Drug 9-chloro-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27285 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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