CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID2474
Family Name Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) Family
No. of Seeds 32 No. of Other Members 64
Family Centroid CFAMM00269020 Functional Category Investigative Drug
Superfamily Neutrophil elastase and Fatty-acid amide hydrolase 1 Binder Superfamily
Class Class 994

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
Cyclooxygenase Inhibitor Oxaprozin Family 33 450
Nitric oxide synthase, endothelial Inhibitor Acclaim Family 2 15
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Benoxapr... 1 76
Neuronal acetylcholine receptor subunit alpha-4 Ligand TC-5619... 3 61
Substance-P receptor Ligand R 673 Family 2 127
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
C-C chemokine receptor type 2 and C-C motif chemokine 2 Ligand... 3 52
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Chymase Inhibitor Y-40613 Family 11 56
Melatonin receptor type 1B Ligand N-(3-benzooxazol-7-yl-propyl... 26 101
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
Fatty-acid amide hydrolase 1 Inhibitor (z)-1-(benzo[d]oxazol-2... 2 27
Fatty-acid amide hydrolase 1 Inhibitor 1-(oxazolo[4,5-b]pyridi... 19 34
Fatty-acid amide hydrolase 1 Inhibitor 1-(5-(pyridin-2-yl)oxaz... 10 142
Vascular endothelial growth factor receptor 1 and Vascular end... 4 44
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Leukotriene A-4 hydrolase Inhibitor 2-[4-(2-azepan-1-ylethoxy)... 5 15
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Peroxisome proliferator-activated receptor alpha Ligand BMS-68... 10 16
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 1 4
Fatty-acid amide hydrolase 1 Inhibitor 3-(benzo[d]oxazol-2-yl)... 1 6
Arachidonate 5-lipoxygenase Inhibitor 5-methyl-n-phenylbenzo[d... 5 13
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 4 4
Peroxisome proliferator-activated receptor delta ligand SureCN... 8 19
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[3-(1,3-be... 3 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 5 25
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 21
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(2-oxo-3... 2 11
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 6 9
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
Histone deacetylase 1 and Histone deacetylase 2 inhibitor AGN-... 4 15
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
5-hydroxytryptamine receptor 3A ligand 2-[(3S)-3-ethylmorpholi... 10 18
5-hydroxytryptamine receptor 3A and Potassium voltage-gated ch... 1 0
Neutrophil elastase inhibitor 1-N-[(2S)-1-[(2S)-2-[[(2S)-1-(1,... 7 1
Neutrophil elastase inhibitor methyl 2-[(2S)-2-[[(2S)-1-[(2S)-... 5 0
Neutrophil elastase inhibitor methyl 2-[(2S)-3-methyl-2-[[(2S)... 2 0
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Thyroid hormone receptor beta ligand CHEMBL1397256 family 1 12
B2 bradykinin receptor ligand SureCN6640854 family 7 4
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Pol polyprotein inhibitor (2S)-4-(1,3-benzoxazol-2-ylmethyl)-1... 1 0
Cathepsin S and Cathepsin K inhibitor N-[(2S)-3-(1-methylcyclo... 2 0
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Thromboxane-A synthase and Thromboxane A2 receptor ligand Sure... 5 37
Inosine-5'-monophosphate dehydrogenase inhibitor SureCN1318237... 2 12
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Fatty-acid amide hydrolase 1 inhibitor methyl 6-[2-[3-(4-pheny... 8 5
Fatty-acid amide hydrolase 1 inhibitor [(2S)-6-phenoxy-1,2,3,4... 3 6
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 4 1
Arachidonate 15-lipoxygenase inhibitor AGN-PC-04S2WZ family 4 9
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor 3-... 4 8
D(2) dopamine receptor and D(3) dopamine receptor ligand N-[3-... 7 3
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and Dual 3',5'... 27 20
Cholinesterase and Acetylcholinesterase inhibitor 4-oxo-N-[9-(... 11 13
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S,... 2 3
Sphingosine 1-phosphate receptor 1 ligand 6-[2-[4-phenyl-3-(tr... 2 3
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 14 24
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-[4-(1,3-benzoxazol... 3 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 8
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Sonic hedgehog protein inhibitor 3-methoxy-1-methyl-4-oxo-5-ph... 5 3
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 3
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
Substance-P receptor ligand AGN-PC-01VLKE family 9 11
Peroxisome proliferator-activated receptor alpha and Peroxisom... 5 2
Peroxisome proliferator-activated receptor gamma and Peroxisom... 10 5
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 1
Fatty-acid amide hydrolase 1 inhibitor alpha-ketooxazole, 4jj ... 1 1
Fatty-acid amide hydrolase 1 inhibitor alpha-ketooxazole, 5a f... 2 1
Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[(2S,5S)-5-(... 20 10
Inosine-5'-monophosphate dehydrogenase inhibitor 2-(2,3-dichlo... 2 0
Inosine-5'-monophosphate dehydrogenase inhibitor (2S)-2-(2,3-d... 4 1
Cathepsin S inhibitor (2S,4R)-4-(benzenesulfonyl)-N-[1-(1,3-be... 4 0
Cathepsin S inhibitor (2S,4R)-4-(benzenesulfonyl)-N-[1-(1,3-be... 4 0
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 1 5
Cholesteryl ester transfer protein inhibitor 2-(4-chloro-2,3-d... 1 1
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 5 2
Coagulation factor X and Plasma kallikrein inhibitor (2R)-N-[2... 1 0
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 1
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 11 3
Neutrophil elastase inhibitor methyl 2-[(2S)-2-[[(2S)-1-[(2S)-... 3 0
Vasopressin V2 receptor ligand SureCN4400636 family 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-2... 1 2
Neutrophil elastase inhibitor 2-[4-[2-[[(2S)-1-[(2S)-2-[[(2S)-... 1 0
Cathepsin S and Cathepsin L1 inhibitor (2S)-2-(1,3-benzoxazol-... 1 9
Cathepsin S and Cathepsin L1 inhibitor SureCN5361439 family 2 4
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Integrin alpha-4 inhibitor (5R)-5-[[(2R)-2-[[2-[4-(1,3-benzoxa... 2 0
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
Collagenase 3 inhibitor SureCN1316041 family 4 3
D(4) dopamine receptor ligand SureCN8704964 family 1 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Metabotropic glutamate receptor 5 ligand SureCN504754 family 5 4
Cholesteryl ester transfer protein inhibitor AGN-PC-09QKST family 1 3
Fatty-acid amide hydrolase 1 inhibitor 7-phenyl-1-[5-[6-(2H-te... 2 0
Cholesteryl ester transfer protein inhibitor AGN-PC-07R9U4 family 1 1
Arachidonate 5-lipoxygenase inhibitor (4E)-4-[(E,4Z)-4-(3H-1,3... 6 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00268986 CHEMBL355937 Bioactive 2-[2-[2-[[(2S)-1-[(2S)-2-[[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethoxy]phenoxy]acetic acid
CFAMM00269056 CHEMBL323030 Bioactive methyl 2-[(2S)-3-methyl-2-[[(2S)-1-[(2S)-3-methyl-2-(phenoxycarbonylamino)butanoyl]pyrrolidine-2-carbonyl]amino]butanoyl]-1,3-benzoxazole-6-carboxylate
CFAMM00269007 CHEMBL152817 Bioactive 3-[4-[2-[[(2S)-1-[(2S)-2-[[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethoxy]phenyl]sulfanyl-2,2-dimethylpropanoic acid
CFAMM00269025 CHEMBL105584 Bioactive (2S)-N-[(2S)-1-(1,3-benzoxazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(2R)-2-(methylamino)-3-phenylpropanoyl]pyrrolidine-2-carboxamide
CFAMM00268985 CHEMBL2380716 Bioactive (2S,4R)-4-(benzenesulfonyl)-N-[1-(1,3-benzoxazol-2-yl)-1-oxobutan-2-yl]-1-benzoylpyrrolidine-2-carboxamide
CFAMM00269032 CHEMBL595073 Bioactive 2-[4-[2-[[(2S)-1-[(2S)-2-[[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethoxy]phenoxy]acetic acid
CFAMM00269006 CHEMBL338651 Bioactive methyl 4-[[(2S)-1-[(2S)-2-[[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamoyl]benzoate
CFAMM00269024 CHEMBL406200 Bioactive (2S)-N-[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-1-[(2S)-3-methyl-2-[(4-sulfamoylbenzoyl)amino]butanoyl]pyrrolidine-2-carboxamide
CFAMM00269046 CHEMBL131107 Bioactive benzyl N-[(2S)-1-[(2S)-2-[[(2S)-1-[5-(hydroxymethyl)-1,3-benzoxazol-2-yl]-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
CFAMM00268960 CHEMBL118176 Bioactive 2-[4-[2-[[(2R)-1-[(2S)-2-[[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethoxy]phenoxy]acetic acid
CFAMM00269053 CHEMBL278682 Bioactive (2S)-N-[(2S)-1-(5-acetamido-1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]-1-[(2S)-2-[(4-methoxybenzoyl)amino]-3-methylbutanoyl]pyrrolidine-2-carboxamide
CFAMM00268998 CHEMBL339650 Bioactive benzyl N-[(2S)-1-[(2S)-2-[[(2S)-1-[5-[[tert-butyl(dimethyl)silyl]oxymethyl]-1,3-benzoxazol-2-yl]-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
CFAMM00269029 CHEMBL273818 Bioactive methyl 2-[(2S)-3-methyl-2-[[(2S)-1-[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]pyrrolidine-2-carbonyl]amino]butanoyl]-1,3-benzoxazole-6-carboxylate
CFAMM00269044 CHEMBL128415 Bioactive benzyl N-[(2S)-1-[(2S)-2-[[(2S)-1-(5-chloro-1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
CFAMM00269051 CHEMBL340627 Bioactive benzyl N-[(2S)-1-[(2S)-2-[[(2S)-1-(5-cyano-1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
CFAMM00268959 CHEMBL324789 Bioactive SureCN8938534
CFAMM00268982 CHEMBL336132 Bioactive 1-N-[(2S)-1-[(2S)-2-[[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]-4-N-methylsulfonylbenzene-1,4-dicarboxamide
CFAMM00268996 CHEMBL335233 Bioactive methyl 2-[2-[(2S)-3-methyl-2-[[(2S)-1-[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]pyrrolidine-2-carbonyl]amino]butanoyl]-1,3-benzoxazol-5-yl]acetate
CFAMM00268966 CHEMBL129496 Bioactive benzyl N-[(2S)-1-[(2S)-2-[[(2S)-1-(5-methoxy-1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
CFAMM00269019 CHEMBL127615 Bioactive 4-N-(benzenesulfonyl)-1-N-[(2S)-1-[(2S)-2-[[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]benzene-1,4-dicarboxamide
CFAMM00269035 CHEMBL130002 Bioactive 1-N-[(2S)-1-[(2S)-2-[[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]-4-N-propan-2-ylsulfonylbenzene-1,4-dicarboxamide
CFAMM00269010 CHEMBL256191 Bioactive [(2S)-3-cyclohexyl-1-morpholin-4-yl-1-oxopropan-2-yl] N-[(1S)-2-(1,3-benzoxazol-2-yl)-1-cyclopropyl-2-oxoethyl]carbamate
CFAMM00269041 CHEMBL269970 Bioactive 1,3-benzoxazol-2-yl-[(2S)-1-[(2S)-1-(3-phenylpropyl)pyrrolidine-2-carbonyl]pyrrolidin-2-yl]methanone
CFAMM00268971 CHEMBL262516 Bioactive tert-butyl 4-[[(2S)-1-[(2S)-2-[[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamoyl]benzoate
CFAMM00268980 CHEMBL2380719 Bioactive (2S,4R)-4-(benzenesulfonyl)-N-[1-(1,3-benzoxazol-2-yl)-1-oxobutan-2-yl]-1-(cyclohexanecarbonyl)pyrrolidine-2-carboxamide
CFAMM00269049 CHEMBL357495 Bioactive 2-[4-[[(2S)-1-[(2S)-2-[[(2S)-1-(1,3-benzoxazol-2-yl)-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamoyl]phenoxy]acetic acid
CFAMM00269009 CHEMBL435413 Bioactive 2-[2-[(2S)-3-methyl-2-[[(2S)-1-[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]pyrrolidine-2-carbonyl]amino]butanoyl]-1,3-benzoxazol-5-yl]acetic acid
CFAMM00268973 DNC008200 Investigative Drug Ac-Ala-Pro-Val-(2-benzoxazole)
CFAMM00269020 DNC008199 Investigative Drug Cbz-Val-Pro-Val-(2-benzoxazole)

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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